专利检索 ap:("Wei Han" OR "Melissa Egbertson" OR "John Wai" OR "Linghang Zhuang" OR "Rowena Ruzek" OR "Debra Perlow" OR "Richard Isaacs" OR "Mark Cameron" OR "Bruce Foster" OR "Ulf Dolling" OR "R. Hoermer" OR "Vanessa Obligado" OR "Lou Neilson" OR "Boyoung Kim" OR "Linda Payne" OR "Matthew Morrissette" OR "Peter Williams" OR "Philip Pye" OR "Remy Angelaud" OR "Danny Mancheno" OR "David Askin") AND inv:"Richard Isaacs" 第 1 页

1.

发明申请
Hiv integrase inhibitors 失效
标题翻译： Hiv整合酶抑制剂

公开(公告)号：US20070179196A1

公开(公告)日：2007-08-02

申请号：US10587682

申请日：2005-03-09

申请人： Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin

发明人： Wei Han , Melissa Egbertson , John Wai , Linghang Zhuang , Rowena Ruzek , Debra Perlow , Richard Isaacs , Mark Cameron , Bruce Foster , Ulf Dolling , R. Hoermer , Vanessa Obligado , Lou Neilson , Boyoung Kim , Linda Payne , Matthew Morrissette , Peter Williams , Philip Pye , Remy Angelaud , Danny Mancheno , David Askin

IPC分类号： A01N37/08

CPC分类号： C07D471/04

摘要： Hydroxy (tetra- or hexa-)hydronaphthyridine dione compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: (I) wherein a, R,1?, R,2?, R,3?, R,4? and R,5? are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.

摘要翻译： 式I的羟基（四或六） - 氢化萘啶二酮化合物是HIV整合酶和HIV复制抑制剂的抑制剂：（I）其中a，R ，1？，R 2？R ，3？，R ，4？并且R ，5？在本文中定义。这些化合物可用于预防和治疗艾滋病毒感染以及预防，延迟艾滋病的发病和治疗。这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。

2.

发明申请
Isoquinolinone potassium channel inhibitors 有权
标题翻译：异喹啉酮钾通道抑制剂

公开(公告)号：US20060270704A1

公开(公告)日：2006-11-30

申请号：US10572343

申请日：2004-09-22

申请人： Richard Isaacs , Christopher Dinsmore , Charles McIntyre , Linda Payne , David Claremon

发明人： Richard Isaacs , Christopher Dinsmore , Charles McIntyre , Linda Payne , David Claremon

IPC分类号： C07D217/22 , A61K31/4704

CPC分类号： C07D217/26 , C07D217/24 , C07D401/04 , C07D401/06 , C07D417/04

摘要： The present invention relates to compounds having the structure formula (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

摘要翻译： 本发明涉及具有结构式（I）的化合物，其可用作治疗心律失常的钾通道抑制剂等。

3.

发明申请
Potassium Channel Inhibitors 有权
标题翻译：钾通道抑制剂

公开(公告)号：US20080090794A1

公开(公告)日：2008-04-17

申请号：US11658114

申请日：2005-07-27

申请人： Christoph Dinsmore , Jeffrey Bergman , Douglas Beshore , B. Wesley Trotter , Kausik Nanda , Richard Isaacs , Linda Payne , Lou Anne Neilson , Zhicai Wu , Mark Bilodeau , Peter Manley , Adrianne Balitza

发明人： Christoph Dinsmore , Jeffrey Bergman , Douglas Beshore , B. Wesley Trotter , Kausik Nanda , Richard Isaacs , Linda Payne , Lou Anne Neilson , Zhicai Wu , Mark Bilodeau , Peter Manley , Adrianne Balitza

IPC分类号： A61K31/5377 , A61K31/397 , A61K31/438 , A61K31/4412 , A61K31/4439 , A61P9/04 , C07D213/04 , C07D221/20 , C07D401/14 , C07D413/02 , C07D413/00 , C07D401/02 , C07D213/63 , A61P9/06 , A61P9/00 , A61K31/444 , A61K31/497 , A61K31/506

CPC分类号： C07D213/36 , C07D213/30 , C07D213/32 , C07D213/38 , C07D213/40 , C07D213/42 , C07D213/55 , C07D213/56 , C07D213/64 , C07D401/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/08 , C07D491/08

摘要： The present invention relates to compounds having the structure useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构的化合物等。

4.

发明申请
Quinazoline potassium channel inhibitors 失效
标题翻译：喹唑啉钾通道抑制剂

公开(公告)号：US20070054894A1

公开(公告)日：2007-03-08

申请号：US10572341

申请日：2004-09-17

申请人： B. Trotter , Richard Isaacs

发明人： B. Trotter , Richard Isaacs

IPC分类号： A61K31/55 , A61K31/517 , A61K31/519 , C07D487/04

CPC分类号： C07D471/04 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D487/04

摘要： The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

摘要翻译： 本发明涉及具有用作治疗心律失常的钾通道抑制剂的结构（I）的化合物等。

5.

发明申请
Method for culturing and expansion of mammalian undifferentiated epidermal kerainocytes exhibiting stem cell characteristics 审中-公开
标题翻译：培养和扩增表现干细胞特性的哺乳动物未分化表皮角质细胞的方法

公开(公告)号：US20050019310A1

公开(公告)日：2005-01-27

申请号：US10499716

申请日：2002-12-20

申请人： Richard Isaacs

发明人： Richard Isaacs

IPC分类号： A61K35/12 , A61K35/36 , A61P17/00 , C12N5/071 , A61K38/17 , A61K45/00

CPC分类号： C12N5/0629 , A61K35/12 , A61K35/36 , C12N5/0698 , C12N2501/117 , C12N2502/094 , C12N2502/1323

摘要： The invention disclosed relates to the culturing of mammalian e.g. human cells, and in particular to the culturing and expansion of substantially undifferentiated human epidermal keratinocytes exhibiting stem cell-like characteristics, and in co-culture with human dermal fibroblasts utilizing a low calcium serum free and animal by-product free medium derived from a commercially available medium. The medium consists of a commercially available basal medium, and a single fibroblast growth factor (FGF) or a mimic thereof e.g. FGF7/KGF. A method is also disclosed for treating mammalian e.g. human skin wound injuries, by applying to the wound an effective amount of substantially pure mammalian e.g. human epidermal stem cell-like keratinocytes in a substantially undifferentiated state, and optionally additionally, dermal fibroblasts e.g. human dermal fibroblasts. Both cell types can be grown separately or in a co-culture for application purposes.

摘要翻译： 所公开的本发明涉及哺乳动物的培养物。特别是培养和扩增显示干细胞样特征的基本上未分化的人表皮角质形成细胞的培养和扩增，并且利用来自商业上的低钙血清游离和动物副产物游离培养基与人真皮成纤维细胞共培养可用介质。培养基由市售的基础培养基和单个成纤维细胞生长因子（FGF）或其模拟物组成。 FGF7 / KGF。还公开了一种治疗哺乳动物的方法。通过向伤口施用有效量的基本上纯的哺乳动物例如人类皮肤伤口损伤。基本上未分化状态的人表皮干细胞样角质形成细胞，以及任选地，皮肤成纤维细胞，例如，人皮肤成纤维细胞。两种细胞类型可以单独种植或共同培养用于应用目的。

6.

发明授权
Quinazoline potassium channel inhibitors 失效
标题翻译：喹唑啉钾通道抑制剂

公开(公告)号：US07906521B2

公开(公告)日：2011-03-15

申请号：US10572341

申请日：2004-09-17

申请人： B. Wesley Trotter , Richard Isaacs

发明人： B. Wesley Trotter , Richard Isaacs

IPC分类号： A61K31/517 , C07D239/88 , C07D239/90 , C07D239/91

CPC分类号： C07D471/04 , C07D239/88 , C07D239/90 , C07D239/91 , C07D239/96 , C07D487/04

摘要： The present invention relates to compounds useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.

摘要翻译： 本发明涉及可用作治疗心律失常的钾通道抑制剂的化合物等。

7.

发明授权
Total synthesis of taxol and analogues thereof 失效
标题翻译：紫杉醇及其类似物的总合成

公开(公告)号：US5597931A

公开(公告)日：1997-01-28

申请号：US436809

申请日：1995-05-05

申请人： Samuel J. Danishefsky , John Masters , Wendy Young , J. Thomas Link , Richard Isaacs , Lawrence B. Snyder

发明人： Samuel J. Danishefsky , John Masters , Wendy Young , J. Thomas Link , Richard Isaacs , Lawrence B. Snyder

IPC分类号： C07C45/29 , C07C45/59 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07C255/31 , C07C255/46 , C07D305/14 , C07D317/72 , C07D493/08 , C07D493/18 , C07F7/18 , C07D317/70

CPC分类号： C07D493/08 , C07C255/31 , C07C255/46 , C07C45/29 , C07C45/59 , C07C49/613 , C07C49/687 , C07C49/713 , C07C49/723 , C07C49/737 , C07C49/747 , C07C49/753 , C07C49/757 , C07D305/14 , C07D317/72 , C07F7/1852 , C07F7/1856 , C07C2101/14 , C07C2101/16

摘要： The present invention provides three basic routes for the total synthesis of taxol having the structure: ##STR1## The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.

摘要翻译： 本发明提供了具有以下结构的紫杉醇的总合成的三种基本途径：本发明还提供了上述方法中制备的中间体，合成这些中间体的方法以及紫杉醇和北美多酚的类似物。