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8 条记录 (耗时 0.031 秒)

    Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds
    1.
    发明授权
    Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds 失效
    手性3-氨基 - 吡咯烷和类似双环化合物的制备方法

    公开(公告)号：US5837868A

    公开(公告)日：1998-11-17

    申请号：US974206

    申请日：1997-11-19

    申请人： Wei-Bo Wang ,  Qun Li ,  Daniel T. Chu ,  Lisa Anne Hasvold

    发明人： Wei-Bo Wang ,  Qun Li ,  Daniel T. Chu ,  Lisa Anne Hasvold

    IPC分类号： C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  C07D471/02 ,  C07D487/02

    CPC分类号： C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  Y02P20/55

    摘要： A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.

    摘要翻译： 通过用异丙醇钛，光学活性酒石酸酯和叔丁基过氧化氢处理二羟基烯烃手性3-氨基吡咯烷和类似双环衍生物的方法，然后用烷基或链烯基卤化镁随后烷基化中间体，然后 通过与芳基甲胺缩合形成吡咯烷环，随后进一步保护具有氨基的环羟基的手性取代，任选的第二环的另外的取代封闭，以及氢解除去环 - 氮保护基。

    Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds
    2.
    发明授权
    Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds 失效
    手性3-氨基 - 吡咯烷和类似双环化合物的制备方法

    公开(公告)号：US5703244A

    公开(公告)日：1997-12-30

    申请号：US754641

    申请日：1996-11-21

    申请人： Qun Li ,  Wei-Bo Wang ,  Daniel T. Chu ,  Lisa Anne Hasvold

    发明人： Qun Li ,  Wei-Bo Wang ,  Daniel T. Chu ,  Lisa Anne Hasvold

    IPC分类号： C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  C07D207/09

    CPC分类号： C07D207/14 ,  C07D455/02 ,  C07D471/04 ,  Y02P20/55

    摘要： A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.

    摘要翻译： 通过用异丙醇钛，光学活性酒石酸酯和叔丁基过氧化氢处理二羟基烯烃手性3-氨基吡咯烷和类似双环衍生物的方法，然后用烷基或链烯基卤化镁随后烷基化中间体，然后 通过与芳基甲胺缩合形成吡咯烷环，随后进一步保护具有氨基的环羟基的手性取代，任选的第二环的另外的取代封闭，以及氢解除去环 - 氮保护基。