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1.发明申请METHOD FOR DETERMINING A RISK, FOR A SUBJECT, OF SUFFERING FROM ATOPIC DERMATITIS OR SEVERITY OF ATOPIC DERMATITIS FOR A SUBJECT SUFFERING FROM ATOPIC DERMATITIS AND METHOD FOR USING A SINGLE-NUCLEOTIDE POLYMORPHISM RS12313273 AS A BIOMARKER FOR DETERMINING THE DEVELOPMENT OR SEVERITY OF ATOPIC DERMATITIS 审中-公开用于确定风险的方法，用于主观因素，从本地化数据或特定目标数据的严重程度减少到使用单核细胞多态性的方法和使用单核多核苷酸的方法RS12313273作为生物标志物用于确定发病或严重程度的原发性公开(公告)号：US20120028827A1
公开(公告)日：2012-02-02
申请号：US13193472
申请日：2011-07-28
申请人： Wei-Chiao Chang , Chih-Hung Lee , Suh-Hang Juo , Wei-Chiao Chen , Hsin-Su Yu
发明人： Wei-Chiao Chang , Chih-Hung Lee , Suh-Hang Juo , Wei-Chiao Chen , Hsin-Su Yu
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The invention provides a method for determining a risk, for a subject, of suffering from atopic dermatitis, including: obtaining a biosample of the subject; detecting the presence of the single-nucleotide polymorphism rs12313273 (C/T) at position 30881 of the ORAI1 gene (SEQ ID No.: 1) in the biosample; and determining the risk, for the subject, of suffering from atopic dermatitis, wherein the presence of a C allele or genotype CC of the single-nucleotide polymorphism rs12313273 (C/T) indicates that the subject is at increased risk for suffering from atopic dermatitis.
摘要翻译： 本发明提供了一种用于确定受试者患有特应性皮炎的风险的方法，包括：获得受试者的生物样品; 检测生物样品中ORAI1基因（SEQ ID No .: 1）的30881位单核苷酸多态性rs12313273（C / T）的存在; 并确定受试者患有特应性皮炎的风险，其中单核苷酸多态性rs12313273（C / T）的C等位基因或基因型CC的存在表明受试者处于患有特应性皮炎的风险增加 。
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公开(公告)号：US08716256B2
公开(公告)日：2014-05-06
申请号：US13152520
申请日：2011-06-03
申请人： Suh-Hang Juo , Ku-Chung Chen , I-Chung Hsieh , Ching-Yu Hu
发明人： Suh-Hang Juo , Ku-Chung Chen , I-Chung Hsieh , Ching-Yu Hu
CPC分类号： C12Q1/6876 , A61K31/7105 , C12N15/1138 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , G01N2800/323 , C12N2310/141 , C12N2330/10
摘要： There is provided a method of therapy of atherosclerosis, by providing microRNA let-7g, an analogue thereof or modified let-7g to organisms to inhibit the expression of lectin-like oxidized low density lipoprotein receptor-1 (LOX-1), and the binding of LOX-1 and oxidized low-density lipoprotein (oxLDL), so as to block the pathogenesis of atherosclerosis. Also, a method of diagnosis of atherosclerosis comprises determining the levels of microRNA let-7g in serum or plasma samples of organisms, in which the levels of microRNA let-7g is estimated in individuals with atherosclerosis as compared to individuals without atherosclerosis.
摘要翻译： 提供了一种治疗动脉粥样硬化的方法，通过向生物体提供microRNA let-7g，其类似物或修饰的let-7g来抑制凝集素样氧化的低密度脂蛋白受体-1（LOX-1）的表达，以及 结合LOX-1和氧化型低密度脂蛋白（oxLDL），从而阻断动脉粥样硬化的发病机制。 此外，动脉粥样硬化的诊断方法包括测定生物体血清或血浆样品中的microRNA let-7g的水平，其中与没有动脉粥样硬化的个体相比，在具有动脉粥样硬化的个体中估计microRNA let-7g的水平。
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