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1.
公开(公告)号:US20190185486A1
公开(公告)日:2019-06-20
申请号:US16326043
申请日:2017-08-14
申请人: Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Cobum , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
发明人: Wensheng Yu , Joseph A. Kozlowski , Ling Tong , Craig A. Cobum , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号: C07D498/04 , A61K31/5365 , A61K31/496 , A61K45/06 , A61P31/14
摘要: The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号:US09828365B2
公开(公告)日:2017-11-28
申请号:US15104584
申请日:2014-12-15
申请人: MERCK SHARP & DOHME CORP. , Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
发明人: Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号: C07D493/04 , C07D405/14 , A61K45/06 , A61K31/4985 , A61K31/7072 , A61K31/4178
CPC分类号: C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要: The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
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3.
公开(公告)号:US20190175602A1
公开(公告)日:2019-06-13
申请号:US16326039
申请日:2017-08-14
申请人: Wensheng Yu , LING Tong , Joseph A. Koziowski , Craig: A Coburn , De-yi J. Yang , Deyou Sha , Jae-Hun. Kim , Michael Dwyer , Kartik M. Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
发明人: Wensheng Yu , LING Tong , Joseph A. Koziowski , Craig: A Coburn , De-yi J. Yang , Deyou Sha , Jae-Hun. Kim , Michael Dwyer , Kartik M. Keertikar , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang
IPC分类号: A61K31/5365 , C07D498/04 , A61P31/14 , A61K31/4995 , C07D519/00
摘要: The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetra-cyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号:US20170217940A1
公开(公告)日:2017-08-03
申请号:US15104584
申请日:2014-12-15
申请人: Joseph KOZLOWSKI , Craig COBURN , Wensheng YU , Bin HU , Bin ZHONG , Jinglai HAO , Dahai WANG , Tao JI , MERCL SHARP & DOHME CORP.
发明人: Joseph Kozlowski , Craig Coburn , Wensheng Yu , Ling Tong , Bin Hu , Bin Zhong , Jinglai Hao , Dahai Wang , Tao Ji
IPC分类号: C07D405/14 , A61K31/4178 , A61K31/7072 , A61K45/06 , A61K31/4985
CPC分类号: C07D405/14 , A61K31/4155 , A61K31/4178 , A61K31/4985 , A61K31/7072 , A61K45/06 , C07D493/04 , A61K2300/00
摘要: The present invention relates to novel Fused Tetracyclic Heterocyclic Compounds of Formula I: (I), wherein A, A′, R2A, R2B, R7, R8, R9, and R10 are defined herein. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by HCV and the prophylaxis, treatment, or delay in the onset of disease caused by HCV. The present invention also relates to pharmaceutical compositions comprising at least one Fused Tetracyclic Heterocyclic Compound, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines, and methods of using the Fused Tetracyclic Heterocyclic Compounds for treating or preventing HCV infection in a patient.
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公开(公告)号:US08178553B2
公开(公告)日:2012-05-15
申请号:US12690633
申请日:2010-01-20
申请人: Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta Maria Kosinski , Seong-Heon Kim , De-Yi Yang , Razia K. Rizvi
发明人: Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Shankar B. Bandarpalle , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Aneta Maria Kosinski , Seong-Heon Kim , De-Yi Yang , Razia K. Rizvi
IPC分类号: A61K31/4178 , A61K31/437 , A61K31/4439 , A61P3/00 , A61P29/00 , A61P11/00 , C07D491/048 , C07D471/04 , C07D401/14 , C07D403/06
CPC分类号: C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗由MMP,ADAM,TACE,聚集蛋白聚糖蛋白酶,TNF-α或其组合介导的疾病或病症 。
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公开(公告)号:US20120010181A1
公开(公告)日:2012-01-12
申请号:US13127952
申请日:2009-11-09
申请人: Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人: Joseph A. Kozlowski , Wensheng Yu , Michael K.C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristen E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号: A61K31/4178 , C07D401/14 , C07D491/052 , C07D413/14 , C07D417/14 , C07D403/14 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/436 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P29/00 , A61P19/02 , A61P1/02 , A61P35/00 , A61P35/04 , A61P25/00 , A61P27/06 , A61P1/00 , A61P17/06 , A61P9/00 , A61P31/18 , A61P31/04 , C07D403/06
CPC分类号: C07D403/14
摘要: This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
摘要翻译: 本发明涉及式(I)的化合物:(化学式应该插在这里,它以纸的形式出现)(I)或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗 由MMP,ADAM,TACE,聚蛋白聚糖蛋白聚糖酶,TNF-或其组合介导的疾病或病症。
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公开(公告)号:US20090156586A1
公开(公告)日:2009-06-18
申请号:US12364845
申请日:2009-02-03
申请人: Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
发明人: Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
IPC分类号: A61K31/4178 , C07D403/06 , C07D401/14 , C07D403/14 , C07D409/14 , C07D417/14 , C07D413/14 , A61K31/427 , A61K31/517 , A61K31/54 , A61K31/5377 , A61K31/4725 , A61K31/4709 , A61K31/4439 , A61K31/506
CPC分类号: C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗由MMP,ADAM,TACE,聚集蛋白聚糖蛋白酶,TNF-α或其组合介导的疾病或病症 。
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公开(公告)号:US20090111803A1
公开(公告)日:2009-04-30
申请号:US12338353
申请日:2008-12-18
申请人: Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K.C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankat
发明人: Wensheng Yu , Ling Tong , Lei Chen , Joseph A. Kozlowski , Brian J. Lavey , Neng-Yang Shih , Vincent S. Madison , Guowei Zhou , Peter Orth , Zhuyan Guo , Michael K.C. Wong , De-Yi Yang , Seong Heon Kim , Bandarpalle B. Shankat
IPC分类号: A61K31/5377 , C07D233/02 , A61K31/4178 , C07D403/02 , C07D277/20 , A61K31/426 , C07D401/14 , A61K31/4709 , A61P19/02 , A61P37/00 , A61P9/00 , A61P29/00 , A61K31/4545 , C07D215/00 , A61K31/4439 , C07D403/14 , A61K31/506 , A61K31/497 , C07D413/14
CPC分类号: C07D401/14 , C07D403/06 , C07D409/14 , C07D413/14 , C07D417/14
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF—or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗由MMP,ADAM,TACE,TNF-或其组合介导的疾病或病症。
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公开(公告)号:US07524842B2
公开(公告)日:2009-04-28
申请号:US11653511
申请日:2007-01-16
申请人: Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
发明人: Brian J. Lavey , Joseph A. Kozlowski , Guowei Zhou , Ling Tong , Wensheng Yu , Michael K. C. Wong , Bandarpalle B. Shankar , Neng-Yang Shih , M. Arshad Siddiqui , Kristin E. Rosner , Chaoyang Dai , Janeta Popovici-Muller , Vinay M. Girijavallabhan , Dansu Li , Razia Rizvi , Lei Chen , De-Yi Yang , Robert Feltz , Seong Heon Kim
IPC分类号: A61K31/428 , A61K31/4015 , A61K31/4166 , C07D209/04 , C07D233/24 , C07D277/34 , C07D417/06
CPC分类号: C07D403/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D473/00
摘要: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-α or combinations thereof.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗由MMP,ADAM,TACE,聚集蛋白聚糖蛋白酶,TNF-α或其组合介导的疾病或病症 。
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公开(公告)号:US08541572B2
公开(公告)日:2013-09-24
申请号:US13127952
申请日:2009-11-09
申请人: Joseph A. Kozlowski , Wensheng Yu , Michael K. C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
发明人: Joseph A. Kozlowski , Wensheng Yu , Michael K. C. Wong , Seong Heon Kim , Ling Tong , Brian J. Lavey , Bandarpalle B. Shankar , De-Yi Yang , Robert Feltz , Aneta Maria Kosinski , Guowei Zhou , Razia K. Rizvi , Chaoyang Dai , Luke Fire , Vinay Girijavallabhan , Dansu Li , Janeta Popovici-Muller , Judson E. Richard , Kristin E. Rosner , M. Arshad Siddiqui , Liping Yang
IPC分类号: C07D295/03 , C07D241/20 , C07D211/30 , C07D213/46 , C07D403/06 , C07D203/16
CPC分类号: C07D403/14
摘要: This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF—or combinations thereof.
摘要翻译: 本发明涉及式(I)的化合物:(化学式应该插在这里,它以纸的形式出现)(I)或其药学上可接受的盐,溶剂合物或异构体,其可用于治疗 由MMP,ADAM,TACE,聚蛋白聚糖蛋白聚糖酶,TNF-或其组合介导的疾病或病症。
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