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23 条记录 (耗时 0.068 秒)

    Human DNA topoisomerase I &agr;
    6.
    发明授权
    Human DNA topoisomerase I &agr; 有权
    人类DNA拓扑异构酶Iα

    公开(公告)号：US06255077B1

    公开(公告)日：2001-07-03

    申请号：US09325430

    申请日：1999-06-04

    申请人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    发明人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    IPC分类号： C12N1563

    CPC分类号： C12N9/90 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  C12Y599/01002

    摘要： Disclosed is a human is a hTopI-&agr; polypeptide and DNA (RNA) encoding such hTopI-&agr; polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-&agr; for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的如抗肿瘤剂的作用以检测自身免疫性疾病或逆转录病毒感染并治疗结肠腺癌的方法。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Human DNA topoisomerase I .alpha.
    7.
    发明授权
    Human DNA topoisomerase I .alpha. 失效
    人类DNA拓扑异构酶Iα

    公开(公告)号：US5968803A

    公开(公告)日：1999-10-19

    申请号：US33153

    申请日：1998-03-02

    申请人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    发明人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N1/21 ,  C12N9/90 ,  C12N15/12 ,  C07K14/435

    CPC分类号： C12N9/90 ,  C12Y599/01002 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00

    摘要： Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    摘要翻译： 公开了人是hTopI-α多肽和编码这种hTopI-α多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法以及针对这种多肽的抗体和拮抗剂。 还提供了使用抗体和拮抗剂抑制剂抑制hTopI-α用于治疗目的的作用的方法，例如抗肿瘤剂，以检测自身免疫疾病或逆转录病毒感染并治疗结肠腺癌。 还公开了用于检测编码序列中的突变和衍生自宿主的样品中多肽浓度变化的诊断方法。

    Human DNA topoisomerase I .alpha.
    8.
    发明授权
    Human DNA topoisomerase I .alpha. 失效

    公开(公告)号：US5723311A

    公开(公告)日：1998-03-03

    申请号：US458477

    申请日：1995-06-02

    申请人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    发明人： Ying-Fei Wei ,  Mark D. Adams ,  Robert D. Fleischmann

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N9/90 ,  C12P21/02 ,  C12N15/12

    CPC分类号： C12N9/90 ,  A61K38/00 ,  A61K48/00

    摘要： Disclosed is a human is a hTopI-.alpha. polypeptide and DNA (RNA) encoding such hTopI-.alpha. polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies and antagonists against such polypeptide. Also provided are methods of using the antibodies and antagonist inhibitors to inhibit the action of hTopI-.alpha. for therapeutic purposes such as an antitumor agent, to detect an autoimmune disease, or retroviral infections and to treat adenocarcinoma of the colon. Diagnostic methods for detecting mutations in the coding sequence and alterations in the concentration of the polypeptides in a sample derived from a host are also disclosed.

    Nucleotide sequence of the Haemophilus influenzae Rd genome, fragments thereof, and uses thereof
    9.
    发明授权
    Nucleotide sequence of the Haemophilus influenzae Rd genome, fragments thereof, and uses thereof 失效
    流感嗜血杆菌Rd基因组的核苷酸序列，其片段及其用途

    公开(公告)号：US06506581B1

    公开(公告)日：2003-01-14

    申请号：US09557884

    申请日：2000-04-25

    申请人： Robert D. Fleischmann ,  Mark D. Adams ,  Owen White ,  Hamilton O. Smith ,  J. Craig Venter

    发明人： Robert D. Fleischmann ,  Mark D. Adams ,  Owen White ,  Hamilton O. Smith ,  J. Craig Venter

    IPC分类号： C12N121

    CPC分类号： C07K14/285 ,  Y10S435/851

    摘要： The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO:1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies over 1700 protein encoding fragments of the genome and identifies, by position relative to a unique Not I restriction endonuclease site, any regulatory elements which modulate the expression of the protein encoding fragments of the Haemophilus genome.

    摘要翻译： 本发明提供了流感嗜血杆菌Rd，SEQ ID NO：1的整个基因组的测序。 本发明还提供存储在计算机可读介质上的序列信息，以及便于其使用的基于计算机的系统和方法。 除了整个基因组序列之外，本发明鉴定了基因组的超过1700个蛋白质编码片段，并且通过相对于独特的Not I限制性内切核酸酶位点的位置鉴定调节嗜血杆菌蛋白编码片段的表达的任何调节元件 基因组

    Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof
    10.
    发明授权
    Computer readable genomic sequence of Haemophilus influenzae Rd, fragments thereof, and uses thereof 失效
    流感嗜血杆菌Rd的计算机可读基因组序列及其用途及其用途

    公开(公告)号：US06355450B1

    公开(公告)日：2002-03-12

    申请号：US08476102

    申请日：1995-06-07

    申请人： Robert D. Fleischmann ,  Mark D. Adams ,  Owen White ,  Hamilton O. Smith ,  J. Craig Venter

    发明人： Robert D. Fleischmann ,  Mark D. Adams ,  Owen White ,  Hamilton O. Smith ,  J. Craig Venter

    IPC分类号： C12P2106

    CPC分类号： C07K14/285 ,  Y10S435/851

    摘要： The present invention provides the sequencing of the entire genome of Haemophilus influenzae Rd, SEQ ID NO: 1. The present invention further provides the sequence information stored on computer readable media, and computer-based systems and methods which facilitate its use. In addition to the entire genomic sequence, the present invention identifies over 1700 protein encoding fragments of the genome and identifies, by position relative to a unique Not I restriction endonuclease site, any regulatory elements which modulate the expression of the protein encoding fragments of the Haemophilus genome.

    摘要翻译： 本发明提供了流感嗜血杆菌Rd，SEQ ID NO：1的整个基因组的测序。本发明还提供存储在计算机可读介质上的序列信息以及便于其使用的基于计算机的系统和方法。 除了整个基因组序列之外，本发明鉴定了基因组的超过1700个蛋白质编码片段，并且通过相对于独特的Not I限制性内切核酸酶位点的位置鉴定调节嗜血杆菌蛋白编码片段的表达的任何调节元件 基因组