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    Novel Compounds
    6.
    发明申请
    Novel Compounds 失效
    新型化合物

    公开(公告)号：US20070270435A1

    公开(公告)日：2007-11-22

    申请号：US11743824

    申请日：2007-05-03

    申请人： William Brown ,  Christopher Walpole ,  Niklas Plobeck ,  Thomas Hudzik

    发明人： William Brown ,  Christopher Walpole ,  Niklas Plobeck ,  Thomas Hudzik

    IPC分类号： A61K31/496 ,  A61P25/24 ,  A61P43/00 ,  C07D295/00

    CPC分类号： C07D295/155 ,  C07D233/24 ,  C07D307/52 ,  C07D333/20

    摘要： The invention relates to at least one compound of general formula I wherein R1 is phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, or pyridine N-oxide, where each R1 phenyl and R1 heteroaromatic ring may optionally and independently be substituted by 1, 2 or 3 substituents selected from CF3, methyl, iodo, bromo, fluoro, and chloro; R2 is independently selected from ethyl and isopropyl; R3 is hydrogen or fluoro; R4 is —NH2 or —NHSO2R5; and R5 is hydrogen, —CF3, or C1-C6 alkyl, or pharmaceutically acceptable salts thereof, at least one process for making at least one compound in accordance with Formula I; at least one method for treating at least one δ receptor associated condition with at least one compound in accordance with Formula I; and at least one pharmaceutical composition comprising at least one compound in accordance with Formula I.

    摘要翻译： 本发明涉及至少一种通式I的化合物，其中R 1是苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基或吡啶N-氧化物，其中每个R 0 > 1苯基和R 1 - 杂芳环可以任选地和独立地被1,2或3个选自CF 3，甲基，碘，溴， 氟和氯; R 2独立地选自乙基和异丙基; R 3是氢或氟; R 4是-NH 2或-NHSO 2 R 5; 和R 5是氢，-CF 3或C 1 -C 6烷基，或其药学上可接受的盐 至少一种根据式I制备至少一种化合物的方法; 用至少一种根据式I的化合物治疗至少一种δ受体相关病症的方法; 和包含至少一种根据式I的化合物的至少一种药物组合物。