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公开(公告)号:US07977481B2
公开(公告)日:2011-07-12
申请号:US12851671
申请日:2010-08-06
申请人: William D. Arnold , Chixu Chen , Stefan N. Gradl , Stephanie Hopkins , Ruo W. Steensma , Masaki Tomimoto , Mark E. Wilson
发明人: William D. Arnold , Chixu Chen , Stefan N. Gradl , Stephanie Hopkins , Ruo W. Steensma , Masaki Tomimoto , Mark E. Wilson
IPC分类号: C07D409/04 , C07D409/14 , C07D239/42 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号: C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新的嘧啶基 - 噻吩激酶调节剂和使用新的嘧啶基 - 噻吩激酶调节剂治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US07803806B2
公开(公告)日:2010-09-28
申请号:US11556033
申请日:2006-11-02
申请人: William D. Arnold , Chixu Chen , Stefan N. Gradl , Stephanie A. Hopkins , Ruo W. Steensma , Masaki Tomimoto , Mark E. Wilson
发明人: William D. Arnold , Chixu Chen , Stefan N. Gradl , Stephanie A. Hopkins , Ruo W. Steensma , Masaki Tomimoto , Mark E. Wilson
IPC分类号: C07D239/42 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号: C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新的嘧啶基 - 噻吩激酶调节剂和使用新的嘧啶基 - 噻吩激酶调节剂治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US20100305128A1
公开(公告)日:2010-12-02
申请号:US12851671
申请日:2010-08-06
申请人: William D. Arnold , Chixu Chen , Stefan N. Gradl , Stephanie A. Hopkins , Ruo W. Steensma , Masaki Tomimoto , Mark E. Wilson
发明人: William D. Arnold , Chixu Chen , Stefan N. Gradl , Stephanie A. Hopkins , Ruo W. Steensma , Masaki Tomimoto , Mark E. Wilson
IPC分类号: A61K31/5377 , C07D401/04 , C07D413/14 , C07D403/14 , C12N9/12 , A61K31/497 , A61P35/00
CPC分类号: C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新的嘧啶基 - 噻吩激酶调节剂和使用新的嘧啶基 - 噻吩激酶调节剂治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US20070117800A1
公开(公告)日:2007-05-24
申请号:US11556033
申请日:2006-11-02
申请人: William Arnold , Chixu Chen , Stefan Gradl , Stephanie Hopkins , Ruo Steensma , Masaki Tomimoto , Mark Wilson
发明人: William Arnold , Chixu Chen , Stefan Gradl , Stephanie Hopkins , Ruo Steensma , Masaki Tomimoto , Mark Wilson
IPC分类号: A61K31/5377 , A61K31/506 , C07D409/14
CPC分类号: C07D409/04 , C07D409/14 , C07D417/14
摘要: The present invention provides novel pyrimidinyl-thiophene kinase modulators and methods of using the novel pyrimidinyl-thiophene kinase modulators to treat diseases mediated by kinase activity.
摘要翻译: 本发明提供新的嘧啶基 - 噻吩激酶调节剂和使用新的嘧啶基 - 噻吩激酶调节剂治疗由激酶活性介导的疾病的方法。
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公开(公告)号:US20080200512A1
公开(公告)日:2008-08-21
申请号:US12070027
申请日:2008-02-14
申请人: Jeffrey Mark Blaney , Normand Hebert , Stephanie Ann Hopkins , Elizabeth A. Jefferson , Masaki Tomimoto
发明人: Jeffrey Mark Blaney , Normand Hebert , Stephanie Ann Hopkins , Elizabeth A. Jefferson , Masaki Tomimoto
IPC分类号: A61K31/445 , C07D211/60 , A61P31/12
CPC分类号: C07D211/16 , C07D211/18 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: The invention provides a compound of formula: and methods for making and using the same, where R1 and R2 are independently hydrogen, C1-6 alkyl or C1-6 haloalkyl; R3 is hydrogen, halogen, C1-6 alkyl or C1-6 alkoxy; R4 is hydrogen or halogen; and R5 is a mono- or di-amino acid moiety, a succinic acid moiety, a urea moiety, or a derivative thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, and methods for making and using the same.
摘要翻译: 本发明提供下式的化合物及其制备和使用方法,其中R 1和R 2独立地是氢,C 1-6烷基, 烷基或C 1-6卤代烷基; R 3是氢,卤素,C 1-6烷基或C 1-6烷氧基; R 4是氢或卤素; R 5是单或二氨基酸部分,琥珀酸部分,脲部分或其衍生物。 本发明还提供了包含式I化合物的药物组合物及其制备和使用方法。
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