公开(公告)号：US20070179190A1

公开(公告)日：2007-08-02

申请号：US10591820

申请日：2005-03-07

申请人： William Hagmann ,  Linus Lin ,  Ping Liu ,  Richard Mumford ,  Thomas Reger ,  Nicholas Smith ,  Nicholas Stock ,  Jasmine Zunic

发明人： William Hagmann ,  Linus Lin ,  Ping Liu ,  Richard Mumford ,  Thomas Reger ,  Nicholas Smith ,  Nicholas Stock ,  Jasmine Zunic

IPC分类号： A61K31/44 ,  A01N43/40

CPC分类号： C07K5/06026 ,  C07D401/12 ,  C07D401/14

摘要： Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.

摘要翻译： 式I的化合物是VLA-4的拮抗剂，因此可用于抑制或预防细胞粘附和细胞粘附介导的病症。 这些化合物可以配制成药物组合物，并且适用于治疗包括溃疡性结肠炎和克罗恩病，多发性硬化，哮喘和类风湿性关节炎的炎性肠病。

公开(公告)号：US20070105866A1

公开(公告)日：2007-05-10

申请号：US11553946

申请日：2006-10-27

申请人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Yiwei Li ,  Jasmine Zunic ,  Jeannie Arruda ,  Nicholas Stock ,  Brian Stearns ,  Mustapha Haddach ,  Jeffrey Roppe

发明人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Yiwei Li ,  Jasmine Zunic ,  Jeannie Arruda ,  Nicholas Stock ,  Brian Stearns ,  Mustapha Haddach ,  Jeffrey Roppe

IPC分类号： A61K31/501 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/427 ,  C07D417/02 ,  C07D403/02

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D403/10 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

公开(公告)号：US20070123522A1

公开(公告)日：2007-05-31

申请号：US11538762

申请日：2006-10-04

申请人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Jasmine Zunic ,  Nicholas Stock

发明人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Jasmine Zunic ,  Nicholas Stock

IPC分类号： A61K31/5415 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/4745 ,  A61K31/519 ,  C07D498/02 ,  C07D491/02 ,  C07D471/02

CPC分类号： C07D491/02 ,  C07D471/04 ,  C07D498/02

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

公开(公告)号：US20070219206A1

公开(公告)日：2007-09-20

申请号：US11744555

申请日：2007-05-04

申请人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Brian Stearns ,  Jeffrey Roppe ,  Bowei Wang ,  Yen Truong ,  Yiwei Li ,  Jasmine Zunic ,  Jeannie Arruda ,  Nicholas Stock ,  Mustapha Haddach ,  Thomas Seiders ,  Jill Scott

发明人： John Hutchinson ,  Petpiboon Prasit ,  Mark Moran ,  Jillian Evans ,  Brian Stearns ,  Jeffrey Roppe ,  Bowei Wang ,  Yen Truong ,  Yiwei Li ,  Jasmine Zunic ,  Jeannie Arruda ,  Nicholas Stock ,  Mustapha Haddach ,  Thomas Seiders ,  Jill Scott

IPC分类号： A61K31/506 ,  A61K31/501 ,  A61K31/497 ,  A61K31/498 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/4439 ,  A61K31/42 ,  A61K31/428 ,  A61K31/404 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

公开(公告)号：US20060189682A1

公开(公告)日：2006-08-24

申请号：US11345694

申请日：2006-02-02

申请人： Joseph Payne ,  Steve Poon ,  Nicholas Smith ,  Nicholas Stock ,  Angela McGuire

发明人： Joseph Payne ,  Steve Poon ,  Nicholas Smith ,  Nicholas Stock ,  Angela McGuire

IPC分类号： A61K31/343 ,  C07D493/10

CPC分类号： C07D493/10

摘要： Disclosed are water soluble compounds which are useful as prodrugs of COX-2 inhibitors, and pharmaceutical compositions comprising them.

摘要翻译： 公开了可用作COX-2抑制剂的前药的水溶性化合物和包含它们的药物组合物。

公开(公告)号：US20070142453A1

公开(公告)日：2007-06-21

申请号：US10580286

申请日：2004-11-25

申请人： Dirk Beher ,  Michela Bettari ,  Ian Churcher ,  Benito Munoz ,  Petpiboon Prasit ,  Abdul Quddus ,  Nicholas Stock ,  Jonathan Wrigley

发明人： Dirk Beher ,  Michela Bettari ,  Ian Churcher ,  Benito Munoz ,  Petpiboon Prasit ,  Abdul Quddus ,  Nicholas Stock ,  Jonathan Wrigley

IPC分类号： A61K31/404 ,  C07D209/36

CPC分类号： C07D417/12 ,  A61K31/405 ,  C07D209/30 ,  C07D209/36 ,  C07D403/12

摘要： Compounds of formula I: modulate the activity of γ-secretase, and hence find use in treatment or prevention of Alzheimer's disease and related conditions.

摘要翻译： 式I化合物：调节γ-分泌酶的活性，因此可用于治疗或预防阿尔茨海默病和相关病症。

公开(公告)号：US20070064220A1

公开(公告)日：2007-03-22

申请号：US10556299

申请日：2004-06-03

申请人： Nicholas Stock ,  Gary Ross ,  David Ledden

发明人： Nicholas Stock ,  Gary Ross ,  David Ledden

IPC分类号： G01N21/47 ,  G01N21/64

CPC分类号： G01N21/251 ,  G01N21/64 ,  G01N21/8483

摘要： A readhead for illuminating a sample carrier and receiving light from the sample carrier, including a housing for receiving a sample carrier, an array of light sources mounted within the housing in a fixed position relative to the sample carrier, and including first and second light-emitting diodes for emitting substantially monochromatic light of a two different wavelengths, a light guide mounted in the housing between the light-emitting diodes and the sample carrier, and a light detector coupled to receive light from the sample carrier. The readhead also includes a light source for directing excitation light of a predetermined wavelength to the sample carrier, and a light filter positioned between the sample carrier and the light detector and adapted to prevent passage therethrough of the excitation light. The readhead allows both fluorescence spectroscopy and reflectance spectroscopy to be conducted on the sample carrier.

摘要翻译： 一种用于照亮样品载体并从样品载体接收光的读取头，包括用于接收样品载体的壳体，安装在壳体内相对于样品载体固定位置的光源阵列，并且包括第一和第二发光层， 用于发射两个不同波长的基本单色光的发光二极管，安装在发光二极管和样品载体之间的壳体中的光导，以及耦合以接收来自样品载体的光的光检测器。 读取头还包括用于将预定波长的激发光引导到样品载体的光源，以及位于样品载体和光检测器之间并适于防止激发光通过的滤光器。 读数头允许在样品载体上进行荧光光谱和反射光谱。

公开(公告)号：US20070225285A1

公开(公告)日：2007-09-27

申请号：US11746010

申请日：2007-05-08

申请人： John Hutchinson ,  Bowei Wang ,  Nicholas Stock ,  Thomas Seiders

发明人： John Hutchinson ,  Bowei Wang ,  Nicholas Stock ,  Thomas Seiders

IPC分类号： A61K31/5377 ,  A61K31/497 ,  A61K31/496 ,  A61K31/454 ,  A61K31/4439 ,  A61K31/433 ,  A61K31/427 ,  A61K31/405

CPC分类号： C07D209/30 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14

摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

公开(公告)号：US20070099950A1

公开(公告)日：2007-05-03

申请号：US10580393

申请日：2004-11-18

申请人： Jongwon Lim ,  Julia Boueres ,  Benito Munoz ,  Richard Pracitto ,  Nicholas Stock ,  Shankar Venkatraman

发明人： Jongwon Lim ,  Julia Boueres ,  Benito Munoz ,  Richard Pracitto ,  Nicholas Stock ,  Shankar Venkatraman

IPC分类号： A61K31/473 ,  C07D219/12

CPC分类号： C07D219/12 ,  C07D215/46

摘要： The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders—such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to α2δ-1 subunit of Ca channels.

摘要翻译： 本发明涉及使用三唑并哒嗪化合物治疗神经性疼痛的方法。 本发明还涉及三唑并 - 哒嗪化合物在治疗精神病和情绪障碍（例如精神分裂症，焦虑症，抑郁症，双相性精神障碍和恐慌）以及治疗疼痛中的应用，帕金森病 疾病，认知功能障碍，癫痫，昼夜节律和睡眠障碍 - 如转移工作诱发的睡眠障碍和时差，药物成瘾，药物滥用，戒毒等疾病。 本发明还涉及选择性结合Ca通道的α2 N-3亚基的新的三唑并 - 哒嗪化合物。

公开(公告)号：US20060063937A1

公开(公告)日：2006-03-23

申请号：US10540601

申请日：2004-01-09

申请人： Benito Munoz ,  Petpiboon Prasit ,  Nicholas Stock

发明人： Benito Munoz ,  Petpiboon Prasit ,  Nicholas Stock

IPC分类号： A61K31/415 ,  C07D491/02 ,  C07D409/02

CPC分类号： C07D257/04 ,  C07C57/30 ,  C07C57/58 ,  C07C59/68 ,  C07D207/20 ,  C07D209/26 ,  C07D209/28 ,  C07D209/46 ,  C07D209/48 ,  C07D209/86 ,  C07D209/88 ,  C07D263/57 ,  C07D333/22 ,  C07D333/24 ,  C07D337/14

摘要： The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is —CO2H, 1H-tetrazol-5-yl or 2H-tetrazol-5-yl and R1 and R2 are each independently selected from the group consisting of: C1-6alkyl and C3-6cycloalkyl, as well as pharmaceutical composition comprising said compounds and methods of using said compounds. The compounds of the present invention lower the level of Aβ42 and are therefore useful for preventing, delaying or reversing the progression of Alzheimer s Disease.

摘要翻译： 本发明包括式I（I）的化合物或其药学上可接受的盐，其中A是丙酸或乙酸NSAID或其衍生物的基础分子，X是-CO 2 H ，1H-四唑-5-基或2H-四唑-5-基和R 1和R 2各自独立地选自：C 1 -C 6烷基， 1-6烷基和C 3-6环烷基，以及包含所述化合物的药物组合物和使用所述化合物的方法。 本发明的化合物降低Abeta 42的水平，因此可用于预防，延缓或逆转阿尔茨海默病的进展。