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公开(公告)号:US20070179190A1
公开(公告)日:2007-08-02
申请号:US10591820
申请日:2005-03-07
申请人: William Hagmann , Linus Lin , Ping Liu , Richard Mumford , Thomas Reger , Nicholas Smith , Nicholas Stock , Jasmine Zunic
发明人: William Hagmann , Linus Lin , Ping Liu , Richard Mumford , Thomas Reger , Nicholas Smith , Nicholas Stock , Jasmine Zunic
CPC分类号: C07K5/06026 , C07D401/12 , C07D401/14
摘要: Compounds of Formula I are antagonists of VLA-4, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of inflammatory bowel disease including ulcerative colitis and Crohn's disease, multiple sclerosis, asthma, and rheumatoid arthritis.
摘要翻译: 式I的化合物是VLA-4的拮抗剂,因此可用于抑制或预防细胞粘附和细胞粘附介导的病症。 这些化合物可以配制成药物组合物,并且适用于治疗包括溃疡性结肠炎和克罗恩病,多发性硬化,哮喘和类风湿性关节炎的炎性肠病。