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公开(公告)号:US5565485A
公开(公告)日:1996-10-15
申请号:US294232
申请日:1994-08-22
申请人: Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy J. Kevin , Douglas J. Pettibone , Ralph A. Rivero , Thomas F. Walsh , David L. Williams, Jr. , Richard B. Toupence , Jay M. Matthews
发明人: Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy J. Kevin , Douglas J. Pettibone , Ralph A. Rivero , Thomas F. Walsh , David L. Williams, Jr. , Richard B. Toupence , Jay M. Matthews
IPC分类号: C07C59/70 , C07C65/24 , C07C311/51 , C07D257/04 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07D409/12 , A61K31/335 , A61K31/535 , C07D265/30 , C07D319/08
CPC分类号: C07D257/04 , C07C311/51 , C07C59/70 , C07C65/24 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07D409/12 , Y10S514/869
摘要: Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
摘要翻译: 苯氧基苯基乙酸和一般结构式I的衍生物具有内皮素拮抗剂活性,可用于治疗心血管疾病,如高血压,缺血性肾衰竭,血管痉挛,脑和心脏缺血,心肌梗死,内毒素性休克,良性前列腺增生 ,包括雷诺氏病和哮喘的炎性疾病。
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2.Heterocyclic compounds bearing acidic functional groups as angiotensin II antagonists 失效
标题翻译: 带有酸性官能团的杂环化合物作为血管紧张素II拮抗剂公开(公告)号:US5412097A
公开(公告)日:1995-05-02
申请号:US940267
申请日:1992-09-02
申请人: Prasun K. Chakravarty , William J. Greenlee , Dooseop Kim , Nathan B. Mantlo , Arthur A. Patchett , Ralph A. Rivero
发明人: Prasun K. Chakravarty , William J. Greenlee , Dooseop Kim , Nathan B. Mantlo , Arthur A. Patchett , Ralph A. Rivero
IPC分类号: C07D471/04 , C07D473/08 , C07D473/32 , C07F9/6561 , A61K31/435 , A61K31/52 , C07D473/00
CPC分类号: C07D471/04 , C07D473/08 , C07D473/32 , C07F9/6561
摘要: Heterocyclic compounds of structural formula: ##STR1## wherein A, B, C, and D are independently carbon atoms or nitrogen atoms are angiotensin II antagonists useful in the treatment of hypertension and congestive heart failure.
摘要翻译: 结构式的杂环化合物:其中A,B,C和D独立地为碳原子或氮原子,可用于治疗高血压和充血性心力衰竭的血管紧张素II拮抗剂。
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公开(公告)号:US5767310A
公开(公告)日:1998-06-16
申请号:US507492
申请日:1995-11-08
申请人: Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy Jo Kevin , Douglas J. Pettibone , Ralph A. Rivero , James R. Tata , Thomas F. Walsh , David L. Williams, Jr.
发明人: Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy Jo Kevin , Douglas J. Pettibone , Ralph A. Rivero , James R. Tata , Thomas F. Walsh , David L. Williams, Jr.
IPC分类号: C07C59/70 , C07C65/24 , C07C311/51 , C07D257/04 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07C59/40
CPC分类号: C07D257/04 , C07C311/51 , C07C59/70 , C07C65/24 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12
摘要: Phenoxyphenylacetic acids and derivatives of general structural formula (I) have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
摘要翻译: PCT No.PCT / US94 / 02871 Sec。 371日期:1995年11月8日 102(e)日期1995年11月8日PCT 1994年3月17日PCT公布。 出版物WO94 / 21590 日期:1994年9月29日苯氧基苯乙酸及其结构式(I)的衍生物具有内皮素拮抗剂活性,可用于治疗高血压,缺血性肾衰竭,血管痉挛,脑和心脏缺血,心肌梗死,内毒素休克,良性 前列腺增生,炎症性疾病包括雷诺氏病和哮喘。
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4.Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs 失效
标题翻译: 含有2-取代的(3S,4S)-4-氨基-5-环己基-3-羟基戊酸,2-取代的(3S,4S)-5-环己基-3,4-二羟基戊酸的环状肾素抑制剂或 (4S,5S)-5-氨基-6-环己基-4-羟基己酸或其类似物公开(公告)号:US5194605A
公开(公告)日:1993-03-16
申请号:US714115
申请日:1991-06-11
申请人: William J. Greenlee , Ralph A. Rivero , Ann E. Weber , Lihu Yang
发明人: William J. Greenlee , Ralph A. Rivero , Ann E. Weber , Lihu Yang
IPC分类号: A61K31/335 , A61K31/357 , A61K31/395 , A61K31/40 , A61K31/41 , A61K31/435 , A61K31/445 , A61K31/535 , A61K38/00 , A61P5/38 , A61P9/00 , A61P9/12 , A61P27/02 , A61P31/12 , A61P43/00 , C07D243/00 , C07D245/02 , C07D267/00 , C07D281/00 , C07D321/00 , C07D327/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D453/02 , C07D487/04 , C07F9/655 , C07F9/6558 , C07F9/6561 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/078 , C07K14/81
CPC分类号: C07D403/12 , C07D243/00 , C07D245/02 , C07D267/00 , C07D281/00 , C07D321/00 , C07D327/02 , C07D401/12 , C07D405/12 , C07D413/10 , C07D417/12 , C07D453/02 , C07D487/04 , C07F9/65525 , C07F9/65586 , C07F9/6561 , C07K5/0205 , C07K5/06078 , C07K5/06139 , A61K38/00
摘要: Compounds of the formula ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, congestive heart failure, and glaucoma.
摘要翻译: 公开了式(I)的化合物。 这些化合物抑制天然蛋白水解酶肾素的血管紧张素原切割作用可用于治疗,预防或控制肾素相关性高血压,醛固酮增多症,充血性心力衰竭和青光眼。
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5.
公开(公告)号:US5449682A
公开(公告)日:1995-09-12
申请号:US61975
申请日:1993-05-17
申请人: William J. Greenlee , David Hangauer , Arthur A. Patchett , Thomas F. Walsh , Kenneth J. Fitch , Daljit S. Dhanoa , Ralph A. Rivero
发明人: William J. Greenlee , David Hangauer , Arthur A. Patchett , Thomas F. Walsh , Kenneth J. Fitch , Daljit S. Dhanoa , Ralph A. Rivero
IPC分类号: A61K31/44 , C07D235/08 , C07D239/36 , C07D239/91 , C07D249/12 , C07D471/04 , A61K31/495 , A61K31/505 , C07D235/04
CPC分类号: C07D471/04 , A61K31/44 , C07D235/08 , C07D239/36 , C07D239/91 , C07D249/12
摘要: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1## wherein the substituents are as defined in the claims.
摘要翻译: 通过亚甲基桥连接到式I的新的取代的苯基衍生物的取代的杂环可用作血管紧张素II拮抗剂。 其中取代基如权利要求中所定义。
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公开(公告)号:US5554625A
公开(公告)日:1996-09-10
申请号:US416790
申请日:1995-01-06
申请人: Ralph A. Rivero , Prasun K. Chakravarty , William J. Greenlee , Nancy J. Kevin , Nathan B. Mantlo
发明人: Ralph A. Rivero , Prasun K. Chakravarty , William J. Greenlee , Nancy J. Kevin , Nathan B. Mantlo
IPC分类号: A61K31/435 , A61P27/02 , C07D471/04
CPC分类号: C07D471/04
摘要: Biphenylmethylimidazopyridines of the structure (I) are angiotensin (II) antagonists and therefore useful in the treatment of hypertension and related cardiovascular disorders and ocular hypertension. ##STR1##
摘要翻译: PCT No.PCT / US93 / 06407 Sec。 371 1995年1月6日第 102(e)日期1995年1月6日PCT提交1993年7月7日PCT公布。 公开号WO94 / 02142 日期1994年2月3日结构(I)的联苯甲基咪唑并吡啶类是血管紧张素(II)拮抗剂,因此可用于治疗高血压和相关心血管疾病和高眼压症。 (一)
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7.Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element 失效
标题翻译: 喹唑啉酮,三唑啉酮和包含取代的苄基元素的嘧啶酮血管紧张素II拮抗剂公开(公告)号:US5264439A
公开(公告)日:1993-11-23
申请号:US744138
申请日:1991-08-13
申请人: William J. Greenlee , David Hangauer , Arthur A. Patchett , Thomas F. Walsh , Kenneth J. Fitch , Daljit S. Dhanoa , Ralph A. Rivero
发明人: William J. Greenlee , David Hangauer , Arthur A. Patchett , Thomas F. Walsh , Kenneth J. Fitch , Daljit S. Dhanoa , Ralph A. Rivero
IPC分类号: C07D235/08 , C07D239/36 , C07D239/91 , C07D249/12 , C07D471/04 , A61K31/505 , C07D239/90
CPC分类号: C07D471/04 , C07D235/08 , C07D239/36 , C07D239/91 , C07D249/12
摘要: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##
摘要翻译: 通过亚甲基桥连接到式I的新的取代的苯基衍生物的取代的杂环可用作血管紧张素II拮抗剂。
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8.Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring 失效
标题翻译: 掺入取代吡啶并咪唑环的血管紧张素II拮抗剂公开(公告)号:US5240938A
公开(公告)日:1993-08-31
申请号:US744557
申请日:1991-08-13
申请人: William J. Greenlee , Arthur A. Patchett , David Hangauer , Thomas F. Walsh , Kenneth J. Fitch , Ralph A. Rivero , Daljit S. Dhanoa
发明人: William J. Greenlee , Arthur A. Patchett , David Hangauer , Thomas F. Walsh , Kenneth J. Fitch , Ralph A. Rivero , Daljit S. Dhanoa
IPC分类号: A61K31/44 , C07D471/04 , C07D491/048
CPC分类号: C07D471/04 , A61K31/44
摘要: Substituted heterocycles attached through a methylene bridge to novel substituted phenyl derivatives of the Formula I are useful as angiotensin II antagonists. ##STR1##
摘要翻译: 通过亚甲基桥连接到式I的新的取代的苯基衍生物的取代的杂环可用作血管紧张素II拮抗剂。
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9.Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole 失效
标题翻译: 加入取代的1,3-苯并间二氧杂环戊烯或1,3-苯并二硫杂的血管紧张素II拮抗剂公开(公告)号:US5187159A
公开(公告)日:1993-02-16
申请号:US773070
申请日:1991-10-07
IPC分类号: A61K31/415 , A61K31/4184 , A61K31/435 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/475 , A61K31/496 , A61K31/52 , A61P9/00 , A61P9/12 , A61P27/02 , A61P43/00 , C07D235/06 , C07D235/08 , C07D235/26 , C07D235/28 , C07D405/06 , C07D409/06 , C07D411/06 , C07D471/04 , C07D473/00
CPC分类号: C07D405/06 , C07D471/04
摘要: 1,3-Benzodioxoles and 1,3-benzodithioles substituted with a 6-fused imidazole of Formula I which are useful as angiotensin II antagonists. ##STR1##
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公开(公告)号:US5668176A
公开(公告)日:1997-09-16
申请号:US733536
申请日:1996-10-18
申请人: Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy Jo Kevin , Gerard R. Kieczykowski , Douglas J. Pettibone , James R. Tata , Ralph A. Rivero , Thomas F. Walsh , David L. Williams, Jr. , Jay M. Matthews , Richard B. Toupence
发明人: Scott W. Bagley , Theodore P. Broten , Prasun K. Chakravarty , Daljit S. Dhanoa , Kenneth J. Fitch , William J. Greenlee , Nancy Jo Kevin , Gerard R. Kieczykowski , Douglas J. Pettibone , James R. Tata , Ralph A. Rivero , Thomas F. Walsh , David L. Williams, Jr. , Jay M. Matthews , Richard B. Toupence
IPC分类号: C07C59/70 , C07C65/24 , C07C311/51 , C07D257/04 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07D409/12 , A61K31/19 , A61K31/535 , C07C59/11 , C07D265/30
CPC分类号: C07D257/04 , C07C311/51 , C07C59/70 , C07C65/24 , C07D317/60 , C07D317/64 , C07D319/18 , C07D405/12 , C07D409/12 , Y10S514/869
摘要: Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are useful in treating cardiovascular disorders, such as hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, benign prostatic hyperplasia, inflammatory diseases including Raynaud's disease and asthma.
摘要翻译: 苯氧基苯基乙酸和一般结构式I的衍生物具有内皮素拮抗剂活性,可用于治疗心血管疾病,如高血压,缺血性肾衰竭,血管痉挛,脑和心脏缺血,心肌梗死,内毒素性休克,良性前列腺增生 ,包括雷诺氏病和哮喘的炎性疾病。
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