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公开(公告)号：US20080194630A1
公开(公告)日：2008-08-14
申请号：US12069943
申请日：2008-02-14
申请人： William T. Barchuk , Paul J. Dunford , James P. Edwards , Anne M. Fourie , Lars Karlsson , Joanne M. Quan
发明人： William T. Barchuk , Paul J. Dunford , James P. Edwards , Anne M. Fourie , Lars Karlsson , Joanne M. Quan
IPC分类号： A61K31/4535 , A61K31/426 , A61K31/423 , A61P43/00
CPC分类号： A61K31/423 , A61K31/426 , A61K31/4535
摘要： Leukotriene A4 hydrolase (LTA4H) inhibitors, compositions containing them, and methods of use for the inhibition of LTA4H enzyme activity and the treatment, prevention or inhibition of inflammation and/or conditions associated with inflammation.
摘要翻译： 白细胞三烯A4水解酶（LTA4H）抑制剂，含有它们的组合物，以及用于抑制LTA4H酶活性以及治疗，预防或抑制与炎症相关的炎症和/或病症的方法。
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公开(公告)号：US07312045B2
公开(公告)日：2007-12-25
申请号：US11012797
申请日：2004-12-15
申请人： Anne M. Fourie , Lars Karlsson , Fawn Coles
发明人： Anne M. Fourie , Lars Karlsson , Fawn Coles
CPC分类号： C12N9/6421
摘要： The present invention describes synthetic peptide substrates of the metalloproteases, aggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases.
摘要翻译： 本发明描述了适用于酶活性测定的金属蛋白酶合用肽底物，聚集蛋白聚糖蛋白聚糖酶-1和/或-22。 本发明还描述了使用这些肽发现调节这些蛋白酶的药剂的方法。
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3.发明申请COMPOUNDS WITH TWO FUSED BICYCLIC HETEROARYL MOIETIES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE 有权具有两个双熔体双组分杂化物的化合物作为LEUKOTRIENE A4水解产物的调节剂公开(公告)号：US20100292208A1
公开(公告)日：2010-11-18
申请号：US12778646
申请日：2010-05-12
申请人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, JR. , Virginia M. Tanis , John J. M. Wiener
发明人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, JR. , Virginia M. Tanis , John J. M. Wiener
IPC分类号： A61K31/397 , C07D417/14 , A61K31/428 , A61K31/454 , A61K31/5377 , A61K31/537 , A61K31/551 , A61P11/06 , A61P17/06 , A61P17/02 , A61P17/00 , A61P3/10 , A61P19/02 , A61P35/00 , A61P1/00 , A61P9/00
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.
摘要翻译： 具有两个稠合双环杂芳基部分的化合物及其药物组合物，以及将其用作白三烯A4水解酶（LTA4H）调节剂并用于治疗由LTA4H介导的疾病，病症和状况的方法。
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4.发明申请Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20090258854A1
公开(公告)日：2009-10-15
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/437 , C07D513/04 , A61K31/506 , A61K31/5377 , A61K31/4985 , A61P29/00 , C12N9/50 , C07D453/02
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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5.发明授权Compounds with two fused bicyclic heteroaryl moieties as modulators of leukotriene A4 hydrolase 有权具有两个稠合双环杂芳基部分的化合物作为白三烯A4水解酶的调节剂公开(公告)号：US08399465B2
公开(公告)日：2013-03-19
申请号：US12778646
申请日：2010-05-12
申请人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Virginia M. Tanis , John J. M. Wiener
发明人： Genesis Bacani , Christa C. Chrovian , Wendy Eccles , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Alejandro Santillán, Jr. , Virginia M. Tanis , John J. M. Wiener
IPC分类号： A61K31/535 , A61K31/47 , A61K31/445 , A61K31/425 , C07D417/14 , C07D417/12
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D493/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： Compounds with two fused bicyclic heteroaryl moieties and their pharmaceutical compositions, and methods of using them as leukotriene A4 hydrolase (LTA4H) modulators and for the treatment of diseases, disorders and conditions mediated by LTA4H.
摘要翻译： 具有两个稠合双环杂芳基部分的化合物及其药物组合物，以及将其用作白三烯A4水解酶（LTA4H）调节剂并用于治疗由LTA4H介导的疾病，病症和状况的方法。
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6.发明申请Thyazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20110159563A1
公开(公告)日：2011-06-30
申请号：US13039017
申请日：2011-03-02
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillán, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： C12N9/99 , C07D513/04
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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