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    HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof
    5.
    发明授权
    HPTH-fragment-(1-37), the preparation thereof, medicaments containing same and the use thereof 失效
    HPTH片段 - （1-37），其制备方法，含有其的药物及其用途

    公开(公告)号：US5744444A

    公开(公告)日：1998-04-28

    申请号：US440117

    申请日：1995-05-12

    申请人： Wolf-Georg Forssmann ,  Franz Herbst ,  Peter Schulz-Knappe ,  Knut Adermann ,  Michael Gagelmann

    发明人： Wolf-Georg Forssmann ,  Franz Herbst ,  Peter Schulz-Knappe ,  Knut Adermann ,  Michael Gagelmann

    IPC分类号： A61K38/00 ,  C07K14/635 ,  A61K38/17 ,  C07K4/635

    CPC分类号： C07K14/635 ,  A61K38/00

    摘要： The invention relates to a peptide from human blood, designated as hPTH-(1-37), the structure of which was elucidated for the purpose of the diagnostic, medical and commercial utilization thereof. The isolation of a fragment hPTH-(38-84) proves the existence of the hPTH-(1-37). A removal of amino-terminal amino acids from the hPTH fragment-(1-37) reduces its biological activity. The hPTH-(1-37) circulating in the blood is identical with the synthetic reference substance hPTH-(1-37), however not with fragments such as hPTH-(1-33), hPTH-(1-34) or hPTH-(1-38). The molecule form hPTH-(1-37) has been proven by mass spectrometry (plasma desorption method). A different biological activity and differences in the three-dimensional peptide structure of the hPTH fragment-(1-37) in comparison to other hPTH fragments furnish evidence of that this fragment is the preferential natural peptide of the parathormone family which should be used for the treatment of diseases of the parathyroid, circulatory system, respiratory system, male genital organ and kidneys.

    摘要翻译： 本发明涉及一种称为hPTH-（1-37）的人血液肽，其结构用于诊断，医学和商业应用的目的。 片段hPTH-（38-84）的分离证明了hPTH-（1-37）的存在。 从hPTH片段（1-37）去除氨基末端氨基酸降低其生物活性。 在血液中循环的hPTH-（1-37）与合成参考物质hPTH-（1-37）相同，但不与hPTH-（1-33），hPTH-（1-34）或hPTH - （1-38）。 分子形式的hPTH-（1-37）已经通过质谱法（血浆解吸法）证实。 与其他hPTH片段相比，hPTH片段（1-37）的三维肽结构的不同生物活性和差异提供了证据，证明该片段是parathormone家族的优选天然肽，其应用于 治疗甲状旁腺，循环系统，呼吸系统，男性生殖器官和肾脏的疾病。