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公开(公告)号：US08530641B2
公开(公告)日：2013-09-10
申请号：US13564161
申请日：2012-08-01
申请人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
发明人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
IPC分类号： A61K31/728 , C08B37/00 , C08B37/08
CPC分类号： A61K31/728 , A61L2/022 , C08B37/0072
摘要： Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 μm or less to provide a sterilized high salt, hyaluronic acid solution.
摘要翻译： 含有重量平均分子量为0.6MDa至3.6Mda的0.04％至0.8％重量的透明质酸和一种或多种选自硼酸，硼酸钠和磷酸二氢钠的缓冲成分的灭菌水溶液。 水溶液的离子强度相当于氯化钠的水溶液浓度为4〜18重量％，pH为6.4〜7.2。 该溶液也通过平均孔径为0.25μm或更小的过滤介质过滤以提供无菌的高盐透明质酸溶液。
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公开(公告)号：US20110195925A1
公开(公告)日：2011-08-11
申请号：US12702540
申请日：2010-02-09
申请人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
发明人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
CPC分类号： A61K31/728 , A61L2/022 , C08B37/0072
摘要： A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
摘要翻译： 一种对包含透明质酸的溶液进行灭菌的方法。 该方法包括提供重均分子量为0.6MDa至3.6MDa的透明质酸水溶液，透明质酸的浓度为0.04％至0.8％重量。 水溶液的离子强度相当于氯化钠水溶液的重量的3〜30重量％。 一旦制备了含水高盐透明质酸溶液，将溶液保持在40℃至80℃的温度下至少1小时且不超过6天。 在热处理步骤之后，通过灭菌过滤介质过滤水溶液，得到无菌高盐透明质酸溶液。
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公开(公告)号：US20120295869A1
公开(公告)日：2012-11-22
申请号：US13564161
申请日：2012-08-01
申请人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
发明人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
IPC分类号： A61K31/728 , A61P19/02 , A61P27/02
CPC分类号： A61K31/728 , A61L2/022 , C08B37/0072
摘要： Sterilized aqueous solution comprising 0.04% to 0.8% by weight hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and one or more buffer components selected from the group consisting of boric acid, sodium borate and sodium dihydrogen phosphate. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 4% to 18% by weight of sodium chloride and a pH from 6.4 to 7.2. The solution is also filtered through a filter medium that has an average pore size of 0.25 μm or less to provide a sterilized high salt, hyaluronic acid solution.
摘要翻译： 含有重量平均分子量为0.6MDa至3.6Mda的0.04％至0.8％重量的透明质酸和一种或多种选自硼酸，硼酸钠和磷酸二氢钠的缓冲成分的灭菌水溶液。 水溶液的离子强度相当于氯化钠的水溶液浓度为4〜18重量％，pH为6.4〜7.2。 溶液也通过平均孔径为0.25μm以下的过滤介质过滤，得到无菌高盐透明质酸溶液。
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公开(公告)号：US08283463B2
公开(公告)日：2012-10-09
申请号：US12702540
申请日：2010-02-09
申请人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
发明人： X. Michael Liu , David J. Heiler , Thomas Menzel , Abbie Brongo , Susan E. Burke , Karl Cummins
CPC分类号： A61K31/728 , A61L2/022 , C08B37/0072
摘要： A process for sterilizing a solution comprising hyaluronic acid. The process comprises providing an aqueous solution of hyaluronic acid with a weight average molecular weight from 0.6 MDa to 3.6 MDa, and the concentration of the hyaluronic acid is from 0.04% to 0.8% by weight. The aqueous solution also has an ionic strength equivalent to an aqueous concentration of sodium chloride from 3% to 30% by weight. Once the aqueous, high salt, hyaluronic acid solution is prepared the solution is maintained at a temperature from 40° C. to 80° C. for at least 1 hour and not longer than six days. Following the heat treatment step, the aqueous solution is filtered through a sterilization filter medium to provide a sterilized high salt, hyaluronic acid solution.
摘要翻译： 一种对包含透明质酸的溶液进行灭菌的方法。 该方法包括提供重均分子量为0.6MDa至3.6MDa的透明质酸水溶液，透明质酸的浓度为0.04％至0.8％重量。 水溶液的离子强度相当于氯化钠水溶液的重量的3〜30重量％。 一旦制备了含水高盐透明质酸溶液，将溶液保持在40℃至80℃的温度下至少1小时且不超过6天。 在热处理步骤之后，通过灭菌过滤介质过滤水溶液，得到无菌高盐透明质酸溶液。
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5.发明申请METHOD OF INCREASING THE EFFECTIVENESS OF A CONTACT LENS CLEANING SOLUTION AGAINST RESISTANT STRAIN FUNGI 审中-公开提高抗菌菌株真菌接触透镜清洁效果的有效性的方法公开(公告)号：US20080031772A1
公开(公告)日：2008-02-07
申请号：US11770110
申请日：2007-06-28
CPC分类号： C11D3/0078 , A61L12/141 , A61L12/143 , C11D1/722 , C11D3/48
摘要： A method of making a disinfecting solution that is effective at disinfecting contact lenses. The method includes the step of combining water, one or more antimicrobial agents and a reduced amount of solid content into a dissolved liquid mixture. The process results in an improved disinfection efficacy compared to a reference solution.
摘要翻译： 制造消毒溶液有效消毒隐形眼镜的方法。 该方法包括将水，一种或多种抗微生物剂和减少量的固体含量混合到溶解的液体混合物中的步骤。 与参考溶液相比，该方法具有改善的消毒效力。
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公开(公告)号：US20080311070A1
公开(公告)日：2008-12-18
申请号：US12131549
申请日：2008-06-02
申请人： Susan E. Burke , Srini Venkatesh , David J. Heiler
发明人： Susan E. Burke , Srini Venkatesh , David J. Heiler
IPC分类号： A61K31/785 , C11D3/37 , A01P1/00
CPC分类号： C11D1/90 , A61L12/142 , C11D1/92 , C11D3/0078 , C11D3/222 , C11D3/227 , C11D3/3723 , C11D3/48
摘要： An ophthalmic composition comprising a polymeric biguanide composition having less than 18 mol % of terminal amine groups and 55 mol % or greater of terminal guanidine groups as measured by 13C NMR, and 0.005 w/v % to 0.04 w/v % hyaluronic acid. Alternatively, the ophthalmic composition comprises a polymeric biguanide composition comprising less than 18 mol % of terminal amine groups and 40 mol % or greater of terminal cyanoguanidino groups as measured by 13C NMR, and 0.005 w/v % to 0.04 w/v % hyaluronic acid. The compositions can be used for cleaning, disinfecting or packaging a contact lens.
摘要翻译： 一种眼用组合物，其包含通过13 C NMR测量的具有小于18摩尔％的末端胺基和55摩尔％以上的末端胍基的聚合双胍组合物和0.005w / v％至0.04w / v％的透明质酸。 或者，眼用组合物包含聚合双胍组合物，其包含小于18mol％的末端胺基和40mol％或更大的末端氰基胍基，通过13 C NMR测量，和0.005w / v％至0.04w / v％透明质酸 。 该组合物可用于清洁，消毒或包装隐形眼镜。
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公开(公告)号：US20100086514A1
公开(公告)日：2010-04-08
申请号：US12571465
申请日：2009-10-01
申请人： X. Michael Liu , David J. Heiler
发明人： X. Michael Liu , David J. Heiler
CPC分类号： A01N47/44 , A01N33/12 , A61L12/142 , A61L12/145 , A01N25/00
摘要： A contact lens care solution comprising: a cationic antimicrobial component having an average molecular weight (MNA), and a cationic oligomer or nitrogen/amine oligomer having a number average molecular weight (MNO) from 500 daltons to 15,000 daltons. The lens care solutions are used to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.
摘要翻译： 一种隐形眼镜护理溶液，其包含：具有平均分子量（MNA）的阳离子抗微生物组分和数均分子量（MNO）为500道尔顿至15,000道尔顿的阳离子低聚物或氮/胺低聚物。 镜片护理液用于清洁和消毒隐形眼镜，特别是柔软的硅胶水凝胶隐形眼镜。
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公开(公告)号：US20070148127A1
公开(公告)日：2007-06-28
申请号：US11611369
申请日：2006-12-15
IPC分类号： A61K31/785 , A61K31/155
CPC分类号： A61L12/142 , A01N47/44 , A01N25/08 , A01N25/34 , A01N2300/00
摘要： An ophthalmic treatment system comprises an ophthalmic treatment solution and a biguanide antimicrobial agent in solid form and in contact with said treatment solution such as to inhibit bacterial and/or fungal growth in said solution. The biguanide is partially or wholly terminated with an amine compound.
摘要翻译： 眼科治疗系统包括固体形式的眼科治疗溶液和双胍抗微生物剂，并与所述治疗溶液接触，以抑制所述溶液中的细菌和/或真菌生长。 双胍部分或全部用胺化合物封端。
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公开(公告)号：US06348508B1
公开(公告)日：2002-02-19
申请号：US09542332
申请日：2000-04-04
IPC分类号： A61K4732
CPC分类号： A61K31/717 , A61K9/0048
摘要： The present invention is directed to a method of treating dry eye by instilling eyedrops of a composition containing a cationic cellulosic polymer. Such compositions have been found to alleviate the symptoms of dry eye without requiring the presence of anionic therapeutic agents. Low ionic strength solutions are particularly preferred.
摘要翻译： 本发明涉及通过滴注含有阳离子纤维素聚合物的组合物的滴眼剂来治疗干眼症的方法。 已经发现这样的组合物可以缓解干眼症状，而不需要存在阴离子治疗剂。 低离子强度溶液是特别优选的。
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10.发明授权
公开(公告)号：US6153568A
公开(公告)日：2000-11-28
申请号：US190509
申请日：1998-11-12
IPC分类号： G02C13/00 , A01N47/44 , A01N59/00 , A61L2/18 , A61L12/14 , C11D3/00 , C11D3/37 , C11D3/48 , F61K31/155 , C11D3/30
CPC分类号： C11D3/48 , A61L12/142 , C11D3/0078 , C11D3/3723
摘要： The present invention is directed to an ophthalmically safe disinfecting solution for contact lenses comprising the combination of a polymeric biguanide and a polyquaternium polymer of a substituted or unsubstituted vinylimidazole or its vinylimidazoliuum salt, which copolymer has a weight average molecular weight of 5,000 to 5,000,000. The invention is also directed to an improved method of disinfecting a contact lens.
摘要翻译： 本发明涉及用于隐形眼镜的眼用安全消毒溶液，其包含聚合双胍和取代或未取代的乙烯基咪唑或其乙烯基咪唑真盐的聚季铵盐聚合物的组合，该共聚物的重均分子量为5,000至5,000,000。 本发明还涉及一种消毒隐形眼镜的改进方法。
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