-
公开(公告)号：US20160129103A1
公开(公告)日：2016-05-12
申请号：US14940799
申请日：2015-11-13
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
-
公开(公告)号：US09889187B2
公开(公告)日：2018-02-13
申请号：US14940799
申请日：2015-11-13
IPC分类号： A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
-
3.发明授权Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof 有权嵌合感染性DNA克隆，嵌合型猪圆环病毒及其用途公开(公告)号：US07276353B2
公开(公告)日：2007-10-02
申请号：US10314512
申请日：2002-12-09
CPC分类号： C07K14/005 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products.
摘要翻译： 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受病毒感染或PCV2引起的断奶后多系统消耗综合征（PMWS）的方法。 新的嵌合感染性DNA克隆及其衍生的无毒性嵌合病毒由非致病性PCV1构建，其中致病性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。
-
公开(公告)号：US09211324B2
公开(公告)日：2015-12-15
申请号：US13268008
申请日：2011-10-07
IPC分类号： A61K39/12 , C07K14/005 , C12N7/00 , A61K39/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
-
5.发明申请CHIMERIC INFECTIOUS DNA CLONES, CHIMERIC PORCINE CIRCOVIRUSES AND USES THEREOF 有权CHIMERIC感染性DNA克隆及其用途及其用途公开(公告)号：US20100055122A1
公开(公告)日：2010-03-04
申请号：US12539540
申请日：2009-08-11
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2, The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
摘要翻译： 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受PCV2引起的病毒感染或断奶后多系统消耗综合征（PMWS）的手段。新的嵌合感染性DNA克隆及其衍生 ，无病毒嵌合病毒由非致病性PCV1构建，其中致病性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。 此外，本发明包括PCV2免疫原性衣壳蛋白基因和蛋白质中的两个突变，以及在嵌合克隆中引入ORF2突变。
-
6.发明申请Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof 有权嵌合感染性DNA克隆，嵌合型猪圆环病毒及其用途公开(公告)号：US20080226666A1
公开(公告)日：2008-09-18
申请号：US11893182
申请日：2007-08-15
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
摘要翻译： 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受病毒感染或PCV2引起的断奶后多系统消耗综合征（PMWS）的方法。 新的嵌合感染性DNA克隆及其衍生的无毒性嵌合病毒由非致病性PCV1构建，其中病原性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。 此外，本发明包括PCV2免疫原性衣壳蛋白基因和蛋白质中的两个突变，以及在嵌合克隆中引入ORF2突变。
-
公开(公告)号：US10507238B2
公开(公告)日：2019-12-17
申请号：US15875892
申请日：2018-01-19
IPC分类号： A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
-
公开(公告)号：US20180147275A1
公开(公告)日：2018-05-31
申请号：US15875892
申请日：2018-01-19
IPC分类号： A61K39/12 , C12N7/00 , C07K14/005 , A61K39/00
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
-
9.发明申请CHIMERIC INFECTIOUS DNA CLONES, CHIMERIC PORCINE CIRCOVIRUSES AND USES THEREOF 审中-公开CHIMERIC感染性DNA克隆及其用途及其用途公开(公告)号：US20130149334A1
公开(公告)日：2013-06-13
申请号：US13268008
申请日：2011-10-07
IPC分类号： A61K39/12
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
摘要翻译： 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受病毒感染或PCV2引起的断奶后多系统消耗综合征（PMWS）的方法。 新的嵌合感染性DNA克隆及其衍生的无毒性嵌合病毒由非致病性PCV1构建，其中病原性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。 此外，本发明包括PCV2免疫原性衣壳蛋白基因和蛋白质中的两个突变，以及在嵌合克隆中引入ORF2突变。
-
10.发明授权Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof 有权嵌合感染性DNA克隆，嵌合型猪圆环病毒及其用途公开(公告)号：US08058048B2
公开(公告)日：2011-11-15
申请号：US12539540
申请日：2009-08-11
IPC分类号： A61K39/295 , C12N7/00
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/54 , A61K2039/552 , C07K14/005 , C12N7/00 , C12N2750/10022 , C12N2750/10034 , C12N2750/10061
摘要： The present invention relates to infectious DNA clones, infectious chimeric DNA clones of porcine circovirus (PCV), vaccines and means of protecting pigs against viral infection or postweaning multisystemic wasting syndrome (PMWS) caused by PCV2. The new chimeric infectious DNA clone and its derived, avirulent chimeric virus are constructed from the nonpathogenic PCV1 in which the immunogenic ORF gene of the pathogenic PCV2 replaces a gene of the nonpathogenic PCV1, preferably in the same position. The chimeric virus advantageously retains the nonpathogenic phenotype of PCV1 but elicits specific immune responses against the pathogenic PCV2. The invention further embraces the immunogenic polypeptide expression products. In addition, the invention encompasses two mutations in the PCV2 immunogenic capsid gene and protein, and the introduction of the ORF2 mutations in the chimeric clones.
摘要翻译： 本发明涉及感染性DNA克隆，猪圆环病毒感染性嵌合DNA克隆（PCV），疫苗和保护猪免受病毒感染或PCV2引起的断奶后多系统消耗综合征（PMWS）的方法。 新的嵌合感染性DNA克隆及其衍生的无毒性嵌合病毒由非致病性PCV1构建，其中病原性PCV2的免疫原性ORF基因替代非致病性PCV1的基因，优选在相同的位置。 嵌合病毒有利地保留了PCV1的非病原性表型，但引发针对致病性PCV2的特异性免疫应答。 本发明还包括免疫原性多肽表达产物。 此外，本发明包括PCV2免疫原性衣壳蛋白基因和蛋白质中的两个突变，以及在嵌合克隆中引入ORF2突变。
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.028 秒)