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公开(公告)号:US20140308317A1
公开(公告)日:2014-10-16
申请号:US14100785
申请日:2013-12-09
申请人: Xiaodong Fan , Yongjiang Xu , Dahui Liu , Michael J. Costanzo
发明人: Xiaodong Fan , Yongjiang Xu , Dahui Liu , Michael J. Costanzo
IPC分类号: C07D279/26 , C07D213/74 , C07D277/28 , C07D261/08 , C07D249/04 , C07D279/28 , C07D209/82 , C07C275/40 , C07C233/80 , C07C279/06 , C07C211/01 , C07C217/62 , C07D265/38 , C07D405/14
CPC分类号: C07D279/26 , C07C211/01 , C07C211/27 , C07C211/28 , C07C211/29 , C07C217/16 , C07C217/20 , C07C217/62 , C07C225/18 , C07C233/75 , C07C233/78 , C07C233/80 , C07C275/40 , C07C279/04 , C07C279/06 , C07C279/08 , C07C2603/18 , C07C2603/32 , C07D209/82 , C07D213/74 , C07D219/14 , C07D249/04 , C07D261/08 , C07D265/38 , C07D271/06 , C07D277/28 , C07D277/30 , C07D279/28 , C07D333/76 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/10 , C07D417/10 , C07D417/12 , C09B21/00 , C09B57/00
摘要: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.
摘要翻译: 本公开提供了用于抑制微生物生长的化合物或其药学上可接受的盐; 治疗具有微生物感染,疟疾,粘膜炎,眼科感染,耳感染,癌症或分枝杆菌感染的哺乳动物; 杀死或抑制疟原虫种类的生长; 抑制分枝杆菌种的生长; 调节哺乳动物的免疫反应; 或拮抗未分级肝素,低分子量肝素或肝素/低分子量肝素衍生物。
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公开(公告)号:US08796275B2
公开(公告)日:2014-08-05
申请号:US12510593
申请日:2009-07-28
申请人: Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
发明人: Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
IPC分类号: C07D241/04 , C07D209/58 , C07D307/91 , C07D333/76 , A61K31/381
CPC分类号: C07D239/28 , C07C217/90 , C07C317/22 , C07C323/42 , C07C323/44 , C07D207/12 , C07D295/096 , C07D295/135 , C07D333/76 , C07D335/12
摘要: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
摘要翻译: 本发明提供了三环化合物,芳酰胺化合物和其它化合物及其组合物,包含其的用于治疗疟疾的组合物,以及治疗疟疾的方法,包括向动物施用此类化合物。
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公开(公告)号:US20100081665A1
公开(公告)日:2010-04-01
申请号:US12510593
申请日:2009-07-28
申请人: Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
发明人: Richard W. Scott , Doron Greenbaum , Dahui Liu , Xiaodong Fan , Yongjiang Xu , Haizhong Tang , Ehab Khalil
IPC分类号: A61K31/496 , C07C237/14 , A61K31/167 , C07D403/12 , A61K31/495 , C07D239/26 , A61P33/06
CPC分类号: C07D239/28 , C07C217/90 , C07C317/22 , C07C323/42 , C07C323/44 , C07D207/12 , C07D295/096 , C07D295/135 , C07D333/76 , C07D335/12
摘要: The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
摘要翻译: 本发明提供了三环化合物,芳酰胺化合物和其它化合物及其组合物,包含其的用于治疗疟疾的组合物,以及治疗疟疾的方法,包括向动物施用此类化合物。
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公开(公告)号:US08278309B2
公开(公告)日:2012-10-02
申请号:US12605584
申请日:2009-10-26
申请人: William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
发明人: William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC分类号: A01N43/54 , C07D239/02
CPC分类号: C07D403/14
摘要: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
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公开(公告)号:US20100105703A1
公开(公告)日:2010-04-29
申请号:US12605584
申请日:2009-10-26
申请人: William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
发明人: William F. DeGrado , Dahui Liu , Richard W. Scott , Yongjiang Xu , Haizhong Tang , Bozena Korczak
IPC分类号: A61K31/506 , C07D403/14 , A61P31/04
CPC分类号: C07D403/14
摘要: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
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公开(公告)号:US08975262B2
公开(公告)日:2015-03-10
申请号:US13563928
申请日:2012-08-01
申请人: William F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
发明人: William F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
IPC分类号: C07D403/14
CPC分类号: C07D403/14
摘要: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
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公开(公告)号:US20130090345A1
公开(公告)日:2013-04-11
申请号:US13563928
申请日:2012-08-01
申请人: Willam F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
发明人: Willam F. DeGrado , Haizhong Tang , Bozena Korczak , Dahui Liu , Richard W. Scott , Yongjiang Xu
IPC分类号: C07D403/14
CPC分类号: C07D403/14
摘要: The present invention provides arylamide compounds and methods of making and using them as antibiotics.
摘要翻译: 本发明提供芳基酰胺化合物及其制备和使用它们作为抗生素的方法。
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公开(公告)号:US20110178104A1
公开(公告)日:2011-07-21
申请号:US12984634
申请日:2011-01-05
申请人: Richard W. Scott , Dahui Liu , Robert W. Kavash , Trevor Young , Michael J. Costanzo , Carol Ann Mulrooney
发明人: Richard W. Scott , Dahui Liu , Robert W. Kavash , Trevor Young , Michael J. Costanzo , Carol Ann Mulrooney
IPC分类号: A61K31/505 , A61K31/4545 , A61K31/445 , A61K31/455 , A61K31/4045 , A61K31/195 , A61K31/167 , C07D239/28 , C07D401/12 , C07D211/60 , C07D213/56 , C07D209/18 , C07C229/00 , C07C233/81 , A61P7/02
CPC分类号: C07C279/08 , A61K31/167 , A61K31/195 , A61K31/4045 , A61K31/445 , A61K31/4545 , A61K31/455 , A61K31/505 , C07C235/60 , C07C235/62 , C07C235/64 , C07C237/42 , C07C279/14 , C07C279/16 , C07C323/63 , C07C2601/14 , C07D207/16 , C07D209/18 , C07D209/20 , C07D209/42 , C07D211/26 , C07D211/58 , C07D213/82 , C07D239/28 , C07D277/56 , C07D403/12
摘要: The present invention provides compounds and methods for antagonizing the anticoagulant effect of an anticoagulant agent that is selected from UFH, LMWH, and a heparin/LMWH derivative in a patient comprising administering to the patient a compound of the invention or a salt thereof, or a composition comprising the same.
摘要翻译: 本发明提供了用于拮抗选自UFH,LMWH和肝素/ LMWH衍生物的抗凝血剂在患者中的抗凝血作用的化合物和方法,包括向患者施用本发明化合物或其盐,或 包含它的组合物。
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公开(公告)号:US20140051762A1
公开(公告)日:2014-02-20
申请号:US13965128
申请日:2013-08-12
申请人: Shaker Mousa , Dahui Liu
发明人: Shaker Mousa , Dahui Liu
IPC分类号: C07C323/63 , C07C237/40
CPC分类号: C07C323/63 , A61K31/167 , C07C219/06 , C07C235/20 , C07C235/56 , C07C235/60 , C07C235/62 , C07C237/40 , C07C237/42 , C07C237/44 , C07C243/38 , C07C279/12 , C07C279/14 , C07C323/42 , C07C2601/14 , C07C2603/92 , C07D239/28
摘要: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.
摘要翻译: 本发明的方面涉及可用于调节血管发生的化合物和方法以及通过施用聚阳离子化合物治疗或预防与血管生成相关的疾病的方法。 本发明涉及包括动物和人在内的哺乳动物中用于抑制血管发生介导的疾病的用途方法和组合物。 另外,本发明涉及聚阳离子与其它抗血管生成剂的组合使用,用于治疗不同的血管发生介导的病症。 此外,这些聚阳离子化合物可以与各种抗炎和细胞毒剂以及癌症患者中的放射治疗剂一起使用以预防和治疗肿瘤生长和转移。
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公开(公告)号:US08455490B2
公开(公告)日:2013-06-04
申请号:US13559065
申请日:2012-07-26
申请人: William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
发明人: William F. DeGrado , Gregory N. Tew , Michael L. Klein , Dahui Liu , Jing Yuan , Sungwook Choi
IPC分类号: A01N43/58 , A01N43/60 , A01N43/54 , A61K31/50 , A61K31/495 , C07D239/42 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号: A61K31/17 , A61K31/16 , A61K31/165 , A61K31/495 , C07C233/64 , C07C323/42 , C07C323/44 , C08G18/3225 , C08G73/028 , C08L75/02
摘要: The present invention discloses methods of use of facially amphiphilic polymers and oligomers, including pharmaceutical uses of the polymers and oligomers as antimicrobial agents and antidotes for hemorrhagic complications associated with heparin therapy. The present invention also discloses novel facially amphiphilic polymers and oligomers and their compositions, including pharmaceutical compositions. The present invention further discloses the design and synthesis of facially amphiphilic polymers and oligomers.
摘要翻译: 本发明公开了使用表面两亲性聚合物和低聚物的方法,包括聚合物和低聚物作为抗微生物剂的药物用途和与肝素治疗相关的出血并发症的解毒剂。 本发明还公开了新颖的表面两亲聚合物和低聚物及其组合物,包括药物组合物。 本发明还公开了表面两亲聚合物和低聚物的设计和合成。
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