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21 条记录 (耗时 0.028 秒)

    Substituted spiroheterocycles
    3.
    发明授权
    Substituted spiroheterocycles 有权
    取代螺旋环

    公开(公告)号：US07825111B2

    公开(公告)日：2010-11-02

    申请号：US11857954

    申请日：2007-09-19

    申请人： Min A. Xiang ,  Mona Patel ,  Philip Rybczynski ,  Joseph Gunnet ,  Keith T. Demarest ,  Richard Look ,  Bruce Maryanoff ,  Michael J. Costanzo ,  Stephen C. Yabut

    发明人： Min A. Xiang ,  Mona Patel ,  Philip Rybczynski ,  Joseph Gunnet ,  Keith T. Demarest ,  Richard Look ,  Bruce Maryanoff ,  Michael J. Costanzo ,  Stephen C. Yabut

    IPC分类号： A61P9/00 ,  A61K31/55 ,  C07D223/14

    CPC分类号： C07D487/10

    摘要： The invention is directed to nonpeptide substituted spiroheterobenzazepine of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased vascular resistance and cardiac insufficiency, including congestive heart failure, hyponatremia, and hypertension. Pharmaceutical compositions comprising a compound of Formula I and methods of treating conditions such as hypertension, congestive heart failure, cardiac insufficiency, coronary vasospasm, cardiac ischemia, liver cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia, stroke, thrombosis, or water retention are also disclosed.

    摘要翻译： 本发明涉及式I的非肽取代的螺杂肼苯并氮平，其可用作加压素受体拮抗剂，用于治疗与加压素受体活性相关的病症，例如涉及增加的血管阻力和心脏功能不全（包括充血性心力衰竭，低钠血症和高血压）的那些。 包含式I化合物的药物组合物和治疗诸如高血压，充血性心力衰竭，心脏功能不全，冠状动脉血管痉挛，心脏缺血，肝硬化，低钠血症，肾血管痉挛，肾衰竭，糖尿病性肾病，脑水肿，脑缺血， 中风，血栓形成或保水性也被公开。

    Methods for treating immunomediated inflammatory disorders
    9.
    发明授权
    Methods for treating immunomediated inflammatory disorders 有权
    治疗免疫性炎症性疾病的方法

    公开(公告)号：US06323219B1

    公开(公告)日：2001-11-27

    申请号：US09238882

    申请日：1999-01-27

    申请人： Michael J. Costanzo

    发明人： Michael J. Costanzo

    IPC分类号： A61K31445

    CPC分类号： A61Q19/04 ,  A61K8/14 ,  A61K8/41 ,  A61K8/42 ,  A61K8/44 ,  A61K8/46 ,  A61K8/4926 ,  A61K8/64 ,  A61K8/676 ,  A61K8/678 ,  A61K8/97 ,  A61Q19/02 ,  Y10S514/826

    摘要： This invention relates to methods ands compositions for bringing about changes in skin pigmentation and for treating inflammatory disorders. More particularly, this invention relates to compounds which affect melanogenesis and can be used as depigmenting agents or as agents for darkening skin utilizing the PAR-2 pathway and compounds for the, prevention and treatment of immunomediated inflammatory diseases, particularly those associated with the respiratory tract, such as asthma and allergic rhinitis.

    摘要翻译： 本发明涉及用于引起皮肤色素沉着变化和治疗炎症性疾病的方法和组合物。 更具体地说，本发明涉及影响黑素生成的化合物，并且可以用作脱色剂或使用PAR-2途径使皮肤变暗的药剂和用于预防和治疗免疫性炎性疾病，特别是与呼吸道相关的炎症疾病的化合物 ，如哮喘和过敏性鼻炎。