摘要:
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for inhibiting the growth of a microbe; treating a mammal having a microbial infection, malaria, mucositis, an ophthalmic infection, an otic infection, a cancer, or a Mycobacterium infection; killing or inhibiting the growth of a Plasmodium species; inhibiting the growth of a Mycobacterium species; modulating an immune response in a mammal; or antagonizing unfractionated heparin, low molecular weight heparin, or a heparin/low molecular weight heparin derivative.
摘要:
The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
摘要:
The present invention provides tricyclic compounds, arylamide compounds, and other compounds, and compositions comprising the same, for treating malaria, and methods of treating malaria comprising administering such compounds to an animal.
摘要:
The present invention discloses compositions of facially amphiphilic compounds and their use in methods for treating or reducing cancers in animals, such as humans.
摘要:
Architecture that includes a multimodal graph modeling and computation system employed in a search framework. The framework utilizes entities to diversify and explore the results page. The multimodal graph modeling paradigm can include web modeling by way of a click graph, a web graph, a social graph, a geospatial graph, and an entity graph, for example. These graphs are then joined based on common properties such as links, clicks, and document entities. Computation can then be performed over the joined graphs to generate a related entity list and a related page list. These lists are then processed by a recommendation engine to provide recommendations to the user.
摘要:
A pattern tree is constructed based on a plurality of key-value pairs representing portions of a data set. In some implementations, the pattern tree may be used for learning one or more rules for interacting with a source of the data set.
摘要:
This invention provides novel heterocyclic derived matrix metalloprotease inhibitors of the formula: and pharmaceutical compositions comprising same, useful for treating disorders ameliorated by antagonizing matrix metalloproteases. This invention also provides therapeutic and prophylactic methods using the instant pharmaceutical compositions.
摘要:
Web crawling polices are generated based on user web browsing statistics. User browsing statistics are aggregated at the granularity of resource identifier patterns (such as URL patterns) that denote groups of resources within a particular domain or website that share syntax at a certain level of granularity. The web crawl policies rank the resource identifier patterns according to their associated aggregated user browsing statistics. A crawl ordering defined by the web crawl polices is used to download and discover new resources within a domain or website.
摘要:
A control circuit, a control method, and a power supply device are provided. The control circuit includes an obtaining sub-circuit, adapted to obtain a voltage signal from a reverse surge current when the reverse surge current appears on a primary side of a switch power circuit of a synchronous rectification circuit; a maintaining sub-circuit, adapted to continuously output a first control signal in a preset first time period when the voltage signal is greater than a preset first voltage threshold; and a control sub-circuit, adapted to control and switch off switch tubes of the secondary side of the switch power circuit of the synchronous rectification circuit according to the first control signal. Thus, a reverse current surge of the switch power circuit of the synchronous rectification circuit can be effectively suppressed, and the safety of a switch power supply of the synchronous rectification circuit can be effectively protected.
摘要:
The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel of influenza viruses (e.g. influenza A virus) and other similar viroporins (e.g., VP24 of Ebola and Marburg viruses; and NS3 protein of Bluetongue). The present invention further relates, inter alia, to compounds which have been shown to possess antiviral activity, in particular, inhibiting the M2 proton channel of influenza viruses.