公开(公告)号：US20100320402A1

公开(公告)日：2010-12-23

申请号：US12819212

申请日：2010-06-20

申请人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

发明人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

摘要翻译： 本文描述了利用三维（3D）剂量格子形成的大剂量网格放射治疗方法。 3D剂量网格可以通过但不限于三种技术方法来实现：1）非共面聚焦束; 2）基于多叶准直器（MLC）的强度调制放射治疗（IMRT）或孔径调制电弧; 和3）重带电粒子束。 3D剂量网格的配置由剂量顶点的数量，位置和剂量组成。 3D剂量网格的最佳配置可以通过手动计算或通过自动化一般算法的计算来实现。 优化算法的目的是通过迭代满足三个条件，直到达到其全局最小值。 使用3D剂量网格，高剂量的辐射集中在肿瘤内的每个晶格顶点，顶点之间具有非常低的剂量（峰 - 谷效应），使组织在肿瘤体外的最低限度暴露。

公开(公告)号：US08395131B2

公开(公告)日：2013-03-12

申请号：US12819212

申请日：2010-06-20

申请人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

发明人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

摘要翻译： 本文描述了利用三维（3D）剂量格子形成的大剂量网格放射治疗方法。 3D剂量网格可以通过但不限于三种技术方法来实现：1）非共面聚焦束; 2）基于多叶准直器（MLC）的强度调制放射治疗（IMRT）或孔径调制电弧; 和3）重带电粒子束。 3D剂量网格的配置由剂量顶点的数量，位置和剂量组成。 3D剂量网格的最佳配置可以通过手动计算或通过自动化一般算法的计算来实现。 优化算法的目的是通过迭代满足三个条件，直到达到其全局最小值。 使用3D剂量网格，高剂量的辐射集中在肿瘤内的每个晶格顶点，顶点之间具有非常低的剂量（峰 - 谷效应），使组织在肿瘤体外的最低限度暴露。

公开(公告)号：US20160256708A9

公开(公告)日：2016-09-08

申请号：US13738099

申请日：2013-01-10

申请人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

发明人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

摘要翻译： 本文描述了利用三维（3D）剂量格子形成的大剂量网格放射治疗方法。 3D剂量网格可以通过但不限于三种技术方法来实现：1）非共面聚焦束; 2）基于多叶准直器（MLC）的强度调制放射治疗（IMRT）或孔径调制电弧; 和3）重带电粒子束。 3D剂量网格的配置由剂量顶点的数量，位置和剂量组成。 3D剂量网格的最佳配置可以通过手动计算或通过自动化一般算法的计算来实现。 优化算法的目的是通过迭代满足三个条件，直到达到其全局最小值。 使用3D剂量网格，高剂量的辐射集中在肿瘤内的每个晶格顶点，顶点之间具有非常低的剂量（峰 - 谷效应），使组织在肿瘤体外的最低限度暴露。

公开(公告)号：US20140194667A1

公开(公告)日：2014-07-10

申请号：US13738099

申请日：2013-01-10

申请人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

发明人： Xiaodong Wu ,  Mansoor M. Ahmed ,  Alan Pollack

IPC分类号： A61N5/10

CPC分类号： A61N5/1031

摘要： A method for high-dose Grid radiotherapy utilizing a three-dimensional (3D) dose lattice formation is described herein. The 3D dose lattice can be achieved by, but not limited to, three technical approaches: 1) non-coplanar focused beams; 2) multileaf collimator (MLC)-based intensity modulated radiation therapy (IMRT) or aperture-modulated arc; and 3) heavy charged particle beam. The configuration of a 3D dose lattice is comprised of the number, location, and dose of dose vertices. The optimal configuration of a 3D dose lattice can be achieved by manual calculations or by automating the calculations for a generic algorithm. The objective of the optimization algorithm is to satisfy three conditions via iteration until they reach their global minimum. With 3D dose lattice, high doses of radiation are concentrated at each lattice vertex within a tumor with drastically lower doses between vertices (peak-to-valley effect), leaving tissue outside of the tumor volume minimally exposed.

摘要翻译： 本文描述了利用三维（3D）剂量格子形成的大剂量网格放射治疗方法。 3D剂量网格可以通过但不限于三种技术方法来实现：1）非共面聚焦束; 2）基于多叶准直器（MLC）的强度调制放射治疗（IMRT）或孔径调制电弧; 和3）重带电粒子束。 3D剂量网格的配置由剂量顶点的数量，位置和剂量组成。 3D剂量网格的最佳配置可以通过手动计算或通过自动化一般算法的计算来实现。 优化算法的目的是通过迭代满足三个条件，直到达到其全局最小值。 使用3D剂量网格，高剂量的辐射集中在肿瘤内的每个晶格顶点，顶点之间具有非常低的剂量（峰 - 谷效应），使组织在肿瘤体外的最低限度暴露。