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公开(公告)号:US06809104B2
公开(公告)日:2004-10-26
申请号:US10289933
申请日:2002-11-06
申请人: Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Thomas Mihalic , Stephen Joseph Shuttleworth
发明人: Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Thomas Mihalic , Stephen Joseph Shuttleworth
IPC分类号: C07D47104
CPC分类号: C07D471/04
摘要: Compounds having the formula: wherein L is a bond or (C1-C4)alkylene, R″ is hydrogen or (C1-C8)alkyl, and R1, R2, R4, R, R′, and the subscript n are as described herein, are provided, which are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorders, obesity, anxiety disorders and mood disorders, are also provided.
摘要翻译: 具有下式的化合物:其中L是一个键或(C 1 -C 4)亚烷基,R“是氢或(C 1 -C 8)烷基,R 1,R 2,R 4,R,R '和下标n如本文所述,其可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症。 还提供了使用这些化合物治疗和/或预防由G蛋白偶联受体介导的病症或病症的药物组合物和方法,例如进食障碍,肥胖症,焦虑障碍和情绪障碍。
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公开(公告)号:US07125885B2
公开(公告)日:2006-10-24
申请号:US10928029
申请日:2004-08-26
申请人: Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Thomas Mihalic , Stephen Joseph Shuttleworth
发明人: Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Thomas Mihalic , Stephen Joseph Shuttleworth
IPC分类号: C07D471/04 , A61K31/437
CPC分类号: C07D471/04
摘要: The present invention provides compounds having the formula: wherein R1, R2, R, R′ and the subscript p are described herein. The compounds are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor, such as eating disorder, obesity, anxiety disorders and mood disorders are also provided.
摘要翻译: 本发明提供具有下式的化合物:其中R 1,R 2,R 2,R 3'和下标p在本文中描述。 该化合物可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症。 还提供了使用这些化合物治疗和/或预防由G蛋白偶联受体介导的病症或病症(如进食障碍,肥胖症,焦虑症和情绪障碍)的药物组合物和方法。
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公开(公告)号:US07253179B2
公开(公告)日:2007-08-07
申请号:US10705173
申请日:2003-11-06
申请人: Xi Chen , Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Jeffrey Thomas Mihalic
发明人: Xi Chen , Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Jeffrey Thomas Mihalic
IPC分类号: A61K31/4745 , C07D471/02
CPC分类号: C07D471/04
摘要: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
摘要翻译: 提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物,组合物和方法。 特别地,本发明的化合物可用于治疗和/或预防进食障碍,肥胖症,焦虑障碍和情绪障碍。
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公开(公告)号:US20050148617A1
公开(公告)日:2005-07-07
申请号:US10928029
申请日:2004-08-26
申请人: Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Mihalic , Stephen Shuttleworth
发明人: Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Mike Lizarzaburu , Jeffrey Mihalic , Stephen Shuttleworth
IPC分类号: A61P3/04 , A61P25/22 , A61P25/24 , C07D471/04 , C07D471/02 , A61K31/4745 , A61K31/55
CPC分类号: C07D471/04
摘要: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
摘要翻译: 提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物,组合物和方法。 特别地,本发明的化合物可用于治疗和/或预防进食障碍,肥胖症,焦虑障碍和情绪障碍。
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公开(公告)号:US07053234B2
公开(公告)日:2006-05-30
申请号:US10877408
申请日:2004-06-25
申请人: Leping Li , Xiaoqi Chen , Pingchen Fan , Jeffrey Thomas Mihalic , Serena Cutler
发明人: Leping Li , Xiaoqi Chen , Pingchen Fan , Jeffrey Thomas Mihalic , Serena Cutler
IPC分类号: C07C275/28
CPC分类号: C07D213/53 , C07C237/04 , C07C259/18 , C07C271/28 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/32 , C07C317/44 , C07C323/60 , C07C323/62 , C07C2601/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/22 , C07D209/18 , C07D209/42 , C07D211/58 , C07D211/70 , C07D215/54 , C07D233/36 , C07D235/30 , C07D263/22 , C07D295/13 , C07D295/135 , C07D295/155 , C07D307/22 , C07D307/54 , C07D307/68 , C07D307/85 , C07D307/86 , C07D317/46 , C07D333/38 , C07D333/60 , C07D333/70
摘要: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
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公开(公告)号:US06780858B2
公开(公告)日:2004-08-24
申请号:US09759633
申请日:2001-01-12
申请人: Leping Li , Xiaoqi Chen , Pingchen Fan , Jeffrey Thomas Mihalic , Serena Cutler
发明人: Leping Li , Xiaoqi Chen , Pingchen Fan , Jeffrey Thomas Mihalic , Serena Cutler
IPC分类号: A61K31397
CPC分类号: C07D213/53 , C07C237/04 , C07C259/18 , C07C271/28 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/32 , C07C317/44 , C07C323/60 , C07C323/62 , C07C2601/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/22 , C07D209/18 , C07D209/42 , C07D211/58 , C07D211/70 , C07D215/54 , C07D233/36 , C07D235/30 , C07D263/22 , C07D295/13 , C07D295/135 , C07D295/155 , C07D307/22 , C07D307/54 , C07D307/68 , C07D307/85 , C07D307/86 , C07D317/46 , C07D333/38 , C07D333/60 , C07D333/70
摘要: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
摘要翻译: 提供了适合作为抗菌剂的羟基脒和相关化合物。
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公开(公告)号:US07148259B1
公开(公告)日:2006-12-12
申请号:US11344111
申请日:2006-02-01
申请人: Leping Li , Xiaoqi Chen , Pingchen Fan , Jeffrey Thomas Mihalic , Serena Cutler
发明人: Leping Li , Xiaoqi Chen , Pingchen Fan , Jeffrey Thomas Mihalic , Serena Cutler
IPC分类号: A61K31/04
CPC分类号: C07D213/53 , C07C237/04 , C07C259/18 , C07C271/28 , C07C275/34 , C07C275/40 , C07C311/21 , C07C311/32 , C07C317/44 , C07C323/60 , C07C323/62 , C07C2601/08 , C07D205/04 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D207/22 , C07D209/18 , C07D209/42 , C07D211/58 , C07D211/70 , C07D215/54 , C07D233/36 , C07D235/30 , C07D263/22 , C07D295/13 , C07D295/135 , C07D295/155 , C07D307/22 , C07D307/54 , C07D307/68 , C07D307/85 , C07D307/86 , C07D317/46 , C07D333/38 , C07D333/60 , C07D333/70
摘要: Hydroxyamidines and related compounds are provided which are suitable as antibacterial agents.
摘要翻译: 提供了适合作为抗菌剂的羟基脒和相关化合物。
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公开(公告)号:US06858619B2
公开(公告)日:2005-02-22
申请号:US10138279
申请日:2002-05-03
申请人: Xiaoqi Chen , Kang Dai , Pingchen Fan , Shugui Huang , Leping Li , Jeffrey Thomas Mihalic
发明人: Xiaoqi Chen , Kang Dai , Pingchen Fan , Shugui Huang , Leping Li , Jeffrey Thomas Mihalic
IPC分类号: A61K31/437 , A61K31/5377 , A61K31/541 , A61P1/14 , A61P3/04 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D471/04
CPC分类号: C07D471/04
摘要: Compounds useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor are provided that have the formula: wherein A and B are CR′; V is either a bond and W is —N(R″)—, or else V is —N(R″)— and W is a bond; Z is —N(R)—CH2—; R1, R2, R3, R4, R′, R″, and R are as defined herein; the subscript n is an integer from 0 to 8; and is a benzene ring. Pharmaceutical compositions and methods of using these compounds for the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders, are also provided.
摘要翻译: 提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物,其具有下式:其中A和B是CR'; V是键,W是-N(R“ ) - ,或者V是-N(R“) - ,W是键; Z是-N(R)-CH 2 - ; R 1,R 2,R 3,R 4 >,R',R“和R如本文所定义;下标n是0至8的整数; 并且是苯环。还提供了使用这些化合物用于治疗和/或预防进食障碍,肥胖,焦虑障碍和情绪障碍的药物组合物和方法。
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公开(公告)号:US20080058365A1
公开(公告)日:2008-03-06
申请号:US11881805
申请日:2007-07-26
申请人: Xi Chen , Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Jeffrey Mihalic
发明人: Xi Chen , Xiaoqi Chen , Pingchen Fan , Juan Jaen , Leping Li , Jeffrey Mihalic
IPC分类号: A61K31/4353 , A61P3/04
CPC分类号: C07D471/04
摘要: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
摘要翻译: 提供了可用于治疗和/或预防由G蛋白偶联受体介导的病症或病症的化合物,组合物和方法。 特别地,本发明的化合物可用于治疗和/或预防进食障碍,肥胖,焦虑障碍和情绪障碍。
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公开(公告)号:US20070135425A1
公开(公告)日:2007-06-14
申请号:US11649938
申请日:2007-01-05
申请人: Xiaoqi Chen , Kang Dai , Pingchen Fan , Shugui Huang , Leping Li , Jeffrey Mihalic
发明人: Xiaoqi Chen , Kang Dai , Pingchen Fan , Shugui Huang , Leping Li , Jeffrey Mihalic
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/4745 , C07D471/02
CPC分类号: C07D471/04
摘要: Compounds, compositions and methods are provided that are useful in the treatment and/or prevention of a condition or disorder mediated by a G-protein coupled receptor. In particular, the compounds of the invention are useful in the treatment and/or prevention of eating disorders, obesity, anxiety disorders and mood disorders.
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