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13 条记录 (耗时 0.018 秒)

    Precise and thorough background subtraction
    1.
    发明授权
    Precise and thorough background subtraction 有权
    精确和彻底的背景减法

    公开(公告)号：US08304719B2

    公开(公告)日：2012-11-06

    申请号：US12709474

    申请日：2010-02-20

    申请人： Xin Wang ,  Haiying Zhang

    发明人： Xin Wang ,  Haiying Zhang

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0036

    摘要： A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples.

    摘要翻译： 用于鉴定和表征复杂样品中感兴趣的组分的方法包括将样品及其对照样品进行色谱/高分辨率质谱分析以检测样品的离子。 该方法包括在测试样本数据中围绕每个离子或每组相同离子的指定色谱波动时间和质量精密窗口中定义控制样本数据的部分。 检查对照样品数据的限定部分，并从测试样品中的相应离子中减去最大强度。 从测试样品的结果数据确定感兴趣的组分。 该方法可用于鉴定复合样品中感兴趣组分的分子离子和/或其碎片离子。

    Precise and thorough background subtraction
    2.
    发明申请
    Precise and thorough background subtraction 有权
    精确和彻底的背景减法

    公开(公告)号：US20100213368A1

    公开(公告)日：2010-08-26

    申请号：US12709474

    申请日：2010-02-20

    申请人： Xin Wang ,  Haiying Zhang

    发明人： Xin Wang ,  Haiying Zhang

    IPC分类号： H01J49/26 ,  H01J49/02

    CPC分类号： H01J49/0036

    摘要： A method for identifying and characterizing components of interest in complex samples includes subjecting both a sample and its control samples to chromatography/high resolution mass spectrometry analysis to detect ions of the samples. The method includes defining sections of control sample data within specified chromatographic fluctuation time and mass precision windows around each ion or each group of the same ions of question in the test sample data. The defined sections of the control sample data are examined and the maximal intensities are subtracted from respective ions in the test sample. Components of interest are determined from the resultant data of the test sample. The method can be used for identifying molecular ions and/or their fragment ions for components of interest in complex samples.

    摘要翻译： 用于鉴定和表征复杂样品中感兴趣的组分的方法包括将样品及其对照样品进行色谱/高分辨率质谱分析以检测样品的离子。 该方法包括在测试样本数据中围绕每个离子或每组相同离子的指定色谱波动时间和质量精密窗口中定义控制样本数据的部分。 检查对照样品数据的限定部分，并从测试样品中的相应离子中减去最大强度。 从测试样品的结果数据确定感兴趣的组分。 该方法可用于鉴定复合样品中感兴趣组分的分子离子和/或其碎片离子。

    Mass defect filter
    5.
    发明授权
    Mass defect filter 有权
    质量缺陷过滤器

    公开(公告)号：US07381568B2

    公开(公告)日：2008-06-03

    申请号：US10858738

    申请日：2004-06-02

    申请人： Haiying Zhang ,  Kenneth L. Ray ,  Donglu Zhang

    发明人： Haiying Zhang ,  Kenneth L. Ray ,  Donglu Zhang

    IPC分类号： G01N24/00

    CPC分类号： H01J49/0027 ,  Y10T436/24

    摘要： A method for detecting and identifying metabolites in biological samples includes subjecting the samples to high resolution mass spectrometry (MS) analysis to detect ions of the molecular species. Mass defect values for the detected ions are determined. The method also includes specifying a predetermined range for mass defect values. Detected ions having mass defect values falling outside the specified range are discarded and those with mass defect values falling within the predetermined range are retained. Species of interest are determined from the retained values. The species of interest include drug metabolites or impurities and/or degradants of a known pharmaceutical sample.

    摘要翻译： 用于检测和鉴定生物样品中代谢物的方法包括对样品进行高分辨质谱（MS）分析以检测分子种类的离子。 确定检测离子的质量缺陷值。 该方法还包括指定质量缺陷值的预定范围。 质量缺陷值超出规定范围的检测离子被丢弃，质量缺陷值落在预定范围内的检测离子被保留。 感兴趣的物种是根据保留值确定的。 感兴趣的物种包括已知药物样品的药物代谢物或杂质和/或降解物。