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公开(公告)号：US20070042392A1
公开(公告)日：2007-02-22
申请号：US11218141
申请日：2005-08-31
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Yunqing Ma , Feiyan Ren , Jian-Rui Wang , Thomas Wehrman , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Yi-Cheng Cao , Dunrui Wang , Zhi Wang , Ryle Goodrich
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-hong Chen , Yunqing Ma , Feiyan Ren , Jian-Rui Wang , Thomas Wehrman , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Yi-Cheng Cao , Dunrui Wang , Zhi Wang , Ryle Goodrich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6883 , C12Q2600/136
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050202422A1
公开(公告)日：2005-09-15
申请号：US10291128
申请日：2002-11-08
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hong Chen , Feiyan Ren , Dunrui Wang , Jian-Rui Wang , Chongjun Xu , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Ryle Goodrich , Radoje Drmanac
CPC分类号： C07K14/8107 , A61K38/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050175607A1
公开(公告)日：2005-08-11
申请号：US10220335
申请日：2001-02-26
申请人： Y Tang , Chenghua Liu , Vinod Asundi , Chongjun Xu , Tom Wehrman , Feiyan Ren , Yunqing Ma , Ping Zhou , Qing Zha , Yonghong Yang , Radoje Drmanac , Jie Zhang , Rui-hong Chen , Jian-Rui Wang , Dunrui Wang , Aidong Xue
发明人： Y Tang , Chenghua Liu , Vinod Asundi , Chongjun Xu , Tom Wehrman , Feiyan Ren , Yunqing Ma , Ping Zhou , Qing Zha , Yonghong Yang , Radoje Drmanac , Jie Zhang , Rui-hong Chen , Jian-Rui Wang , Dunrui Wang , Aidong Xue
CPC分类号： C07K14/47 , C12Q1/6886
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050239060A1
公开(公告)日：2005-10-27
申请号：US10122851
申请日：2002-04-12
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Jie Zhang , Feiyan Ren , Rui-hong Chen , Qing Zhao , Tom Wehrman , Aidong Xue , Yonghong Yang , Jian-Rui Wang , Ping Zhou , Yunqing Ma , Dunrui Wang , Zhiwei Wang , Radoje Drmanac
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Jie Zhang , Feiyan Ren , Rui-hong Chen , Qing Zhao , Tom Wehrman , Aidong Xue , Yonghong Yang , Jian-Rui Wang , Ping Zhou , Yunqing Ma , Dunrui Wang , Zhiwei Wang , Radoje Drmanac
CPC分类号： C07K14/47 , A61K2039/505
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20050221342A1
公开(公告)日：2005-10-06
申请号：US10972024
申请日：2004-10-22
申请人： Y. Tang , Vinod Asundi , Ping Zhou , Aidong Xue , Feiyan Ren , Jie Zhang , Jian-Rui Wang , Yonghong Yang , Qing Zhao , Ryle Goodrich , Chenghua Liu , Radoje Drmanac , Yunqing Ma , Zhiwei Wang , Tom Wehrman
发明人： Y. Tang , Vinod Asundi , Ping Zhou , Aidong Xue , Feiyan Ren , Jie Zhang , Jian-Rui Wang , Yonghong Yang , Qing Zhao , Ryle Goodrich , Chenghua Liu , Radoje Drmanac , Yunqing Ma , Zhiwei Wang , Tom Wehrman
CPC分类号： C07K14/47 , C12Q1/6837
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US20070049743A1
公开(公告)日：2007-03-01
申请号：US10294433
申请日：2002-11-13
申请人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hung Chen , Feiyan Ren , Jian-Rui Wang , Tom Wehrman , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Ryle Goodrich
发明人： Y. Tang , Chenghua Liu , Vinod Asundi , Rui-Hung Chen , Feiyan Ren , Jian-Rui Wang , Tom Wehrman , Aidong Xue , Yonghong Yang , Jie Zhang , Qing Zhao , Ping Zhou , Radoje Drmanac , Ryle Goodrich
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US06743619B1
公开(公告)日：2004-06-01
申请号：US09774528
申请日：2001-01-30
申请人： Y. Tom Tang , Ping Zhou , Ryle Goodrich , Chenghua Liu , Vinod Asundi , Feiyan Ren , Jie Zhang , Qing A. Zhao , Yonghong Yang , Aidong J. Xue , Tom Wehrman , Jian-Rui Wang , Dunrui Wang , Radoje T. Drmanac
发明人： Y. Tom Tang , Ping Zhou , Ryle Goodrich , Chenghua Liu , Vinod Asundi , Feiyan Ren , Jie Zhang , Qing A. Zhao , Yonghong Yang , Aidong J. Xue , Tom Wehrman , Jian-Rui Wang , Dunrui Wang , Radoje T. Drmanac
IPC分类号： C12N990
CPC分类号： C07K14/47 , G01N2500/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译： 本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。
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公开(公告)号：US20050170374A1
公开(公告)日：2005-08-04
申请号：US10945678
申请日：2004-09-20
申请人： Y. Tang , Zhi Wang , Ping Zhou , Chongjun Xu , Feiyan Ren , Rui-Hong Chen , Jian-Rui Wang , Yonghong Yang , Radoje Drmanac
发明人： Y. Tang , Zhi Wang , Ping Zhou , Chongjun Xu , Feiyan Ren , Rui-Hong Chen , Jian-Rui Wang , Yonghong Yang , Radoje Drmanac
IPC分类号： A61K38/00 , C07K14/47 , C07K14/81 , C07K16/00 , C12N9/16 , C12N9/64 , C12Q1/68 , C07H21/04 , C07K16/18
CPC分类号： C12N9/6432 , A01K2217/05 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/8107 , C07K16/00 , C07K2319/00 , C12N9/16 , C12Y304/21006
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
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公开(公告)号：US08748377B2
公开(公告)日：2014-06-10
申请号：US13133976
申请日：2009-12-10
申请人： Mark A. Bush , Murray W. Stewart , Yonghong Yang
发明人： Mark A. Bush , Murray W. Stewart , Yonghong Yang
CPC分类号： A61K38/26 , A61K45/06 , C07K14/605
摘要： The present invention provides pharmaceutical compositions comprising at least one polypeptide having GLP-1 activity wherein an effective dose of said pharmaceutical composition comprises 15 mg, 30 mg, 50 mg or 100 mg of said polypeptide having GLP-1 activity. Also provided are methods of administering the pharmaceutical compositions of the invention.
摘要翻译： 本发明提供包含至少一种具有GLP-1活性的多肽的药物组合物，其中所述药物组合物的有效剂量包含15mg，30mg，50mg或100mg所述具有GLP-1活性的多肽。 还提供了施用本发明的药物组合物的方法。
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10.发明授权Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes 有权装载胶乳光学分子成像探针，含有亲脂性大型斯托克斯位移染料公开(公告)号：US08906354B2
公开(公告)日：2014-12-09
申请号：US13043057
申请日：2011-03-08
申请人： Tao Ji , Hans F. Schmitthenner , Yonghong Yang , John W. Harder , Jeffrey W. Leon , William J. Harrison , Brian J. Kelley , James R. Bennett , David A. Stegman , Ruizheng Wang
发明人： Tao Ji , Hans F. Schmitthenner , Yonghong Yang , John W. Harder , Jeffrey W. Leon , William J. Harrison , Brian J. Kelley , James R. Bennett , David A. Stegman , Ruizheng Wang
CPC分类号： A61K49/0054 , A61K49/0032 , A61K49/0093 , B82Y15/00
摘要： The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.
摘要翻译： 本发明涉及包含至少一种荧光染料的负载颗粒，特别是具有大的斯托克斯位移的荧光染料。 本发明还涉及一种负载胶乳粒子的方法，该方法装载有具有较大的斯托克斯位移的荧光染料。 此外，本发明涉及装有荧光染料的胶乳颗粒，其是可溶于和不溶于水的有机溶剂。 在优选的实施方案中，当将染料加载到水溶性胶乳颗粒中时，与水性溶剂中染料的量子产率相比，观察到荧光量子产率的增加。
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