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![Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/abs-image/US/2006/04/25/US07034152B2/abs.jpg.150x150.jpg)
1.发明授权Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one 有权制备抗病毒剂的方法[1S-（1α，3α，4beta）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-亚甲基环戊基] -6H-嘌呤 -6-one公开(公告)号：US07034152B2
公开(公告)日：2006-04-25
申请号：US10734012
申请日：2003-12-11
申请人： Yadagiri R. Pendri , Chung-Pin H. Chen , Sunil S. Patel , Jeffrey M. Evans , Jing Liang , David R. Kronenthal , Gerald L. Powers , Siva Josyula Prasad , Jeffrey T. Bien , Zhongping Shi , Ramesh N. Patel , Amit Banerjee , Yeung Yu Chan , Sushil K. Rijhwani , Ambarish K. Singh , Shaopeng Wang , Milan Stojanovic , David J. Kucera , Richard P. Polniaszek , Charles Lewis , John Thottathil , Dhileepkumar Krishnamurty , Maotang X. Zhou , Purushotham Vemishetti
发明人： Yadagiri R. Pendri , Chung-Pin H. Chen , Sunil S. Patel , Jeffrey M. Evans , Jing Liang , David R. Kronenthal , Gerald L. Powers , Siva Josyula Prasad , Jeffrey T. Bien , Zhongping Shi , Ramesh N. Patel , Amit Banerjee , Yeung Yu Chan , Sushil K. Rijhwani , Ambarish K. Singh , Shaopeng Wang , Milan Stojanovic , David J. Kucera , Richard P. Polniaszek , Charles Lewis , John Thottathil , Dhileepkumar Krishnamurty , Maotang X. Zhou , Purushotham Vemishetti
IPC分类号： C07D473/18 , C07D7/08 , C07D473/40 , C07F7/10 , C07F7/18
CPC分类号： C07F7/083 , C07D473/18 , C07F7/081 , C07F7/0812 , C07F7/0814 , C07F7/0827 , C07F7/1804
摘要： Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
摘要翻译： 公开了制备抗病毒剂恩替卡韦的方法。 还公开了用于恩替卡韦的分离和纯化的树脂吸附方法。 还公开了可用于制备恩替卡韦的各种中间体。
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![Intermediates in the preparation of the antiviral agent [1S-(1α, 3α, 4β)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxmethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/abs-image/US/2009/06/23/US07550619B2/abs.jpg.150x150.jpg)
2.发明授权Intermediates in the preparation of the antiviral agent [1S-(1α, 3α, 4β)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxmethyl)-2-methylenecyclopentyl]-6H-purin-6-one 有权制备抗病毒剂的中间体[1S-（1α，3α，4beta）] - 2-氨基-1,9-二氢-9- [4-羟基-3-（羟甲基）-2-亚甲基环戊基] 嘌呤-6-酮公开(公告)号：US07550619B2
公开(公告)日：2009-06-23
申请号：US11311598
申请日：2005-12-19
申请人： Yadagiri R. Pendri , Chung-Pin H. Chen , Jing Liang , Shaopeng Wang , Milan Stojanovic , Richard P. Polniaszek , John Thottathil , Dhileepkumar Krishnamurty
发明人： Yadagiri R. Pendri , Chung-Pin H. Chen , Jing Liang , Shaopeng Wang , Milan Stojanovic , Richard P. Polniaszek , John Thottathil , Dhileepkumar Krishnamurty
CPC分类号： C07F7/083 , C07D473/18 , C07F7/081 , C07F7/0812 , C07F7/0814 , C07F7/0827 , C07F7/1804
摘要： Intermediates useful in the preparation of the antiviral agent entecavir are disclosed. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various processes useful in the preparation of entecavir are also disclosed.
摘要翻译： 公开了用于制备抗病毒剂恩替卡韦的中间体。 还公开了用于恩替卡韦的分离和纯化的树脂吸附方法。 还公开了可用于制备恩替卡韦的各种方法。
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![Process for preparing the antiviral agent [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one](/abs-image/US/2006/05/18/US20060106216A1/abs.jpg.150x150.jpg)
公开(公告)号：US20060106216A1
公开(公告)日：2006-05-18
申请号：US11311598
申请日：2005-12-19
申请人： Yadagiri Pendri , Chung-Pin Chen , Jing Liang , Shaopeng Wang , Milan Stojanovic , Richard Polniaszek , John Thottathil , Dhileepkumar Krishnamurty
发明人： Yadagiri Pendri , Chung-Pin Chen , Jing Liang , Shaopeng Wang , Milan Stojanovic , Richard Polniaszek , John Thottathil , Dhileepkumar Krishnamurty
IPC分类号： C07D473/10
CPC分类号： C07F7/083 , C07D473/18 , C07F7/081 , C07F7/0812 , C07F7/0814 , C07F7/0827 , C07F7/1804
摘要： Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.
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公开(公告)号：US20050202503A1
公开(公告)日：2005-09-15
申请号：US11123648
申请日：2005-05-06
申请人： Milan Stojanovic , Donald Landry
发明人： Milan Stojanovic , Donald Landry
IPC分类号： A01N61/00 , C07H21/02 , C07H21/04 , C07K1/00 , C07K16/00 , C12M1/34 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01N20060101 , G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , Y10T436/143333
摘要： Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a calorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000 μM. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of the sensor. As the dye is insoluble in buffer, cocaine binding can be detected as displaced dye precipitates and supernatant decolorizes.
摘要翻译： 抗可卡因适配体和染料二乙基硫代花青的复合物作为量热传感器，其浓度范围为2-5000μM，可卡因在760nm处的吸光度衰减。 机理研究表明染料的分子间位移作为传感器的作用机理。 由于染料不溶于缓冲液，可检测到可卡因结合作为置换的染料沉淀物，上清液脱色。
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公开(公告)号：US20150044672A1
公开(公告)日：2015-02-12
申请号：US14343741
申请日：2012-09-07
申请人： Milan Stojanovic , Steven Taylor
发明人： Milan Stojanovic , Steven Taylor
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6816 , C12Q2525/207 , C12Q2537/161 , C12Q2563/131
摘要： Provided are compositions including a streptavidin composition in which a plurality of biotin binding sites are blocked by tethered biotins. Also provided are methods of using such compositions, including cell imaging, nucleic acid analysis or detection, or biotinylation quantification.
摘要翻译： 提供了包含链霉亲和素组合物的组合物，其中多个生物素结合位点被系链生物素阻断。 还提供了使用这种组合物的方法，包括细胞成像，核酸分析或检测或生物素化定量。
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公开(公告)号：US20050130208A1
公开(公告)日：2005-06-16
申请号：US10990187
申请日：2004-11-16
申请人： Milan Stojanovic , Donald Landry
发明人： Milan Stojanovic , Donald Landry
IPC分类号： A01N61/00 , C07H21/02 , C07H21/04 , C07K1/00 , C07K16/00 , C12M1/34 , C12Q1/00 , C12Q1/68 , C12Q1/70 , G01N20060101 , G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , Y10T436/143333
摘要： Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a calorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-5000 μM. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of the sensor. As the dye is insoluble in buffer, cocaine binding can be detected as displaced dye precipitates and supernatant decolorizes.
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7.发明申请Cross reactive arrays of three-way junction sensors for steriod determination 审中-公开三相接头传感器的交叉反应阵列，用于测定公开(公告)号：US20050019916A1
公开(公告)日：2005-01-27
申请号：US10824158
申请日：2004-04-14
申请人： Milan Stojanovic , Donald Landry , Dragan Nikic
发明人： Milan Stojanovic , Donald Landry , Dragan Nikic
IPC分类号： C07H21/02 , C12N15/11 , C12N15/115 , A61K48/00
CPC分类号： C12N15/111 , C07H21/02 , C12N15/115 , C12N2310/16 , C12N2320/10 , C12N2330/31
摘要： This invention provides analyte sensitive oligonucleotide compositions for detecting and analyzing analytes in solution, including complex solutions using cross reactive arrays of analyte sensitive oligonucleotide compositions.
摘要翻译： 本发明提供用于检测和分析溶液中分析物的分析物敏感寡核苷酸组合物，包括使用分析物敏感性寡核苷酸组合物的交叉反应性阵列的复
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公开(公告)号：US20160031854A1
公开(公告)日：2016-02-04
申请号：US14800194
申请日：2015-07-15
IPC分类号： C07D401/12 , C07D215/44 , C07D233/60
CPC分类号： C07D401/12 , C07D215/44 , C07D233/60
摘要： Disclosed herein is an in vitro or in vivo method of activating or reversing inactivation of acetylcholinesterase (AChE) or butyrylcholinesterase (BuchE) using compounds of the present disclosure. Also disclosed is a method of treating a subject exposed to a nerve agent using such compounds. Also disclosed is a method of treating organophosphate poisoning in a subject using such compounds. Also disclosed is a method of modulating neuronal signaling and transmission in a subject using such compounds.
摘要翻译： 本文公开了使用本公开的化合物活化或逆转乙酰胆碱酯酶（AChE）或丁酰胆碱酯酶（BuchE）的灭活的体外或体内方法。 还公开了使用这些化合物治疗暴露于神经药物的受试者的方法。 还公开了使用这种化合物治疗受试者中的有机磷中毒的方法。 还公开了使用这些化合物调节受试者的神经元信号传导和传播的方法。
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公开(公告)号：US20060194231A1
公开(公告)日：2006-08-31
申请号：US11340145
申请日：2006-01-25
申请人： Milan Stojanovic , Sergei Rudchenko
发明人： Milan Stojanovic , Sergei Rudchenko
IPC分类号： C12Q1/68
CPC分类号： G01N33/5308 , C12Q1/6837 , C12Q2565/626 , C12Q2563/149
摘要： Cross-reactive arrays on encoded beads are used to correlate ‘fingerprints’ of urine, serum and other biological liquids to disease states. Fluorescent hydrophobic sensors are based on nucleic acid three-way junctions, and beads may be encoded by size (could be registered by light scattering) and fluorescence in combination with flow cytometry analysis, also known as suspension array technology (SAT).
摘要翻译： 编码珠上的交叉反应阵列用于将尿液，血清和其他生物液体的“指纹”与疾病状态相关联。 荧光疏水传感器基于核酸三向接头，珠可以通过尺寸（可以通过光散射记录）和荧光结合流式细胞术分析（也称为悬浮阵列技术（SAT））编码。
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10.发明申请Cross reactive arrays of three-way junction sensors for steroid determination 有权用于类固醇测定的三路连接传感器的交叉反应阵列公开(公告)号：US20060204977A1
公开(公告)日：2006-09-14
申请号：US11251496
申请日：2005-10-14
申请人： Milan Stojanovic , Donald Landry , Dragan Nikic
发明人： Milan Stojanovic , Donald Landry , Dragan Nikic
CPC分类号： C07H21/02 , C07H21/04 , C12N15/111 , C12N15/115 , C12N2310/16 , C12N2320/10 , C12N2330/31 , C12Q1/6816 , C12Q2563/107 , C12Q2565/107
摘要： This invention provides analyte sensitive oligonucleotide compositions for detecting and analyzing analytes in solution, including complex solutions using cross reactive arrays of analyte sensitive oligonucleotide compositions.
摘要翻译： 本发明提供用于检测和分析溶液中分析物的分析物敏感寡核苷酸组合物，包括使用分析物敏感性寡核苷酸组合物的交叉反应性阵列的复
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