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118 条记录 (耗时 0.032 秒)

    N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
    5.
    发明授权
    N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives 失效
    N-苯基苯并咪唑酰胺和N-苯基吲哚甲酰胺衍生物

    公开(公告)号：US06583169B2

    公开(公告)日：2003-06-24

    申请号：US09928722

    申请日：2001-08-13

    申请人： Raymond F. Horvath ,  Ping Ge ,  Taeyoung Yoon ,  Alan Hutchison

    发明人： Raymond F. Horvath ,  Ping Ge ,  Taeyoung Yoon ,  Alan Hutchison

    IPC分类号： A61K31404

    CPC分类号： C07D235/14 ,  C07D209/14 ,  G01N2333/726

    摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein; A is N or CH; R1 and R2 represents hydrogen or lower alkyl; G, R3, R4, R5, R6, R7 and R8 are variables defined herein. These compounds are modulators of CRF receptors and are therefore useful for treating affective disorders, anxiety, depression, eating disorders, and stress disorders in humans and other animals. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

    摘要翻译： 公开了下式的化合物或其药学上可接受的无毒盐，其中A是N或CH; R 1和R 2表示氢或低级烷基; G，R 3，R 4，R 5，R 6，R 7和R 8是本文定义的变量 这些化合物是CRF受体的调节剂，因此可用于治疗人类和其他动物中的情感障碍，焦虑症，抑郁症，进食障碍和应激障碍。 还提供了治疗这种病症以及包装的药物组合物的方法。本发明的化合物还可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。 给出了在受体定位研究中使用化合物的方法。

    Substituted heterocyclic diarylamine analogues
    6.
    发明申请
    Substituted heterocyclic diarylamine analogues 审中-公开
    取代的杂环二芳基胺类似物

    公开(公告)号：US20070043049A1

    公开(公告)日：2007-02-22

    申请号：US10564431

    申请日：2004-07-09

    申请人： Rajagopal Bakthavatchalam ,  Kevin Hodgetts ,  Alan Hutchison ,  Robert Ohliger ,  Taeyoung Yoon ,  Xiaozhang Zheng

    发明人： Rajagopal Bakthavatchalam ,  Kevin Hodgetts ,  Alan Hutchison ,  Robert Ohliger ,  Taeyoung Yoon ,  Xiaozhang Zheng

    IPC分类号： A61K31/53

    CPC分类号： C07D401/12 ,  A61K31/506 ,  A61K31/53 ,  C07D251/52 ,  C07D251/54 ,  C07D401/14 ,  G01N33/566

    摘要： Substituted heterocyclic diarylamine analogues of Formula I are provided: wherein X, Y and Z are independently N or optionally substituted C, and other variables are as described in the specification. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using them to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

    摘要翻译： 提供式I的取代的杂环二芳基胺类似物：其中X，Y和Z独立地为N或任选被取代的C，并且其它变量如说明书中所述。 这些化合物是可用于在体内或体外调节特异性受体活性的配体，并且特别可用于治疗与人类，驯养伴侣动物和家畜中的病理受体激活相关的病症。 还提供了用于治疗这些病症的药物组合物和方法，以及使用这些配体进行受体定位研究的方法。

    N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives
    8.
    发明授权
    N-phenyl benzimidazolecarboxamide and N-phenyl indolecarboxamide derivatives 失效
    N-苯基苯并咪唑酰胺和N-苯基吲哚甲酰胺衍生物

    公开(公告)号：US06281237B1

    公开(公告)日：2001-08-28

    申请号：US09540478

    申请日：2000-03-31

    申请人： Raymond F. Horvath ,  Ping Ge ,  Taeyoung Yoon ,  Alan Hutchison

    发明人： Raymond F. Horvath ,  Ping Ge ,  Taeyoung Yoon ,  Alan Hutchison

    IPC分类号： A61K314184

    CPC分类号： C07D235/14 ,  C07D209/14 ,  G01N2333/726

    摘要： Disclosed are compounds of the forumla: or the pharmaceutically acceptable non-toxic salts thereof wherein; A is N or CH; R1 and R2 represents hydrogen or lower alkyl; G, R3, R4, R5, R6, R7 and R8 are variables defined herein. These compounds are modulators of CRF receptors and are therefore useful for treating affective disorders, anxiety, depression, eating disorders, and stress disorders in humans and other animals. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRF receptor binding. Methods of using the compounds in receptor localization studies are given.

    摘要翻译： 公开了该论坛的化合物或其药学上可接受的无毒盐，其中：A是N或CH; R 1和R 2表示氢或低级烷基; G，R 3，R 4，R 5，R 6，R 7和R 8是本文定义的变量 这些化合物是CRF受体的调节剂，因此可用于治疗人类和其他动物中的情感障碍，焦虑症，抑郁症，进食障碍和应激障碍。 还提供了治疗这种病症以及包装的药物组合物的方法。本发明的化合物还可用作CRF受体定位的探针，并且作为用于CRF受体结合的测定中的标准物。 给出了在受体定位研究中使用化合物的方法。