公开(公告)号：US20060192101A1

公开(公告)日：2006-08-31

申请号：US11414177

申请日：2006-05-01

申请人： Yasuaki Takada ,  Minoru Sakairi

发明人： Yasuaki Takada ,  Minoru Sakairi

IPC分类号： B01D59/44 ,  H01J49/00

CPC分类号： H01J49/0031 ,  G01N33/0057 ,  H01J49/004 ,  H01J49/424

摘要： An analyzing method which includes ionizing a sample, dissociating plurality of precursor ions which have different m/z values, and deciding if fragment ions of a predetermined m/z value are present.

摘要翻译： 一种分析方法，其包括电离样品，解离多个具有不同m / z值的前体离子，并确定是否存在具有预定m / z值的碎片离子。

公开(公告)号：US20050199801A1

公开(公告)日：2005-09-15

申请号：US11123202

申请日：2005-05-06

申请人： Yasuaki Takada ,  Minoru Sakairi

发明人： Yasuaki Takada ,  Minoru Sakairi

IPC分类号： B01D59/44 ,  H01J49/42

CPC分类号： H01J49/0031 ,  G01N33/0057 ,  H01J49/004 ,  H01J49/424

摘要： An analyzing method using a tandem mass spectrometric apparatus includes a first analysis step of acquiring a mass spectrum, a decision step of deciding if ions of a predetermined m/z value are present, and a second analysis step of acquiring a tandem mass spectrum according to the decision results from the first analysis step.

摘要翻译： 使用串联质谱仪的分析方法包括获取质谱的第一分析步骤，判定是否存在预定m / z值的离子的判定步骤，以及根据下述方法获取串联质谱的第二分析步骤 决策结果来自第一个分析步骤。

公开(公告)号：US06437327B2

公开(公告)日：2002-08-20

申请号：US09859508

申请日：2001-05-18

申请人： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

发明人： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

IPC分类号： H01J4910

CPC分类号： H01J49/165 ,  G01N30/7266 ,  H01J49/168

摘要： A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to or at an angle with respect to a center axis of the aperture, and a tip of the needle is disposed facing to an electrode having the aperture.

摘要翻译： 一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔 设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。 由喷雾器引起的喷雾方向几乎与孔的中心轴垂直或成一定角度，并且针的尖端面向具有孔的电极。

公开(公告)号：US6157030A

公开(公告)日：2000-12-05

申请号：US143398

申请日：1998-08-28

申请人： Minoru Sakairi ,  Tadao Mimura ,  Toshihiro Ishizuka ,  Masaru Tomioka ,  Yasuaki Takada ,  Takayuki Nabeshima

发明人： Minoru Sakairi ,  Tadao Mimura ,  Toshihiro Ishizuka ,  Masaru Tomioka ,  Yasuaki Takada ,  Takayuki Nabeshima

IPC分类号： H01J49/42

CPC分类号： H01J49/424

摘要： Disclosed is an ion trap mass spectrometer improved to obtain a high sensitivity without the lowering of resolution. By fitting a mesh electrode to an aperture (an ion sampling aperture or an ion extracting aperture) made in endcap electrodes constituting an ion trap mass analysis region, a radio frequency electric field in the mass analysis region is not disturbed even if the diameter of the aperture is set to a large value to heighten ion transmission efficiency. By fitting a shield electrode for preventing collision of ions with an insulated ring constituting an outer wall of the mass analysis region, charging up of the insulated ring is prevented to improve stability of detection signals. Furthermore, by arranging a shield member for shielding stray charged particles detouring through the circumference of the mass analysis region to approach an ion detector, generation of noises based on these stray charged particles is prevented.

摘要翻译： 公开了一种改进的离子阱质谱仪，可以在不降低分辨率的情况下获得高灵敏度。 通过将网状电极装配到构成离子阱质量分析区域的端盖电极中的孔（离子取样孔或离子提取孔）上，即使直径为 孔径被设定为大的值以提高离子传输效率。 通过安装用于防止离子与构成质量分析区域的外壁的绝缘环碰撞的屏蔽电极，防止了绝缘环的充电以提高检测信号的稳定性。 此外，通过设置用于屏蔽通过质量分析区域的圆周去除杂散带电粒子的屏蔽构件以接近离子检测器，防止了基于这些杂散带电粒子的噪声的产生。

公开(公告)号：US6114693A

公开(公告)日：2000-09-05

申请号：US299638

申请日：1999-04-27

申请人： Atsumu Hirabayashi ,  Yukiko Hirabayashi ,  Minoru Sakairi ,  Yasuaki Takada ,  Takayuki Nabeshima ,  Hideaki Koizumi

发明人： Atsumu Hirabayashi ,  Yukiko Hirabayashi ,  Minoru Sakairi ,  Yasuaki Takada ,  Takayuki Nabeshima ,  Hideaki Koizumi

IPC分类号： G01N27/62 ,  G01N27/447 ,  G01N30/72 ,  H01J49/04 ,  H01J49/10

CPC分类号： G01N30/7266 ,  H01J49/0468 ,  H01J49/167

摘要： A mass spectrometer comprising a passage through which a sample solution flows, the passage including a capillary having an open tip, the sample solution flowing through the capillary out of the open tip of the capillary, a gas passage which forms a gas flow around the open tip of the capillary, the gas flow spraying the sample solution flowing out of the open tip of the capillary, a first electrode which contacts the sample solution flowing in the passage and applies an electric potential to the sample solution flowing in the passage, a second electrode disposed around the capillary near the open tip of the capillary, the second electrode being downstream from the first electrode with respect to a direction in which the sample solution flows in the passage, there being no gap extending downstream from the open tip of the capillary to the second electrode in a direction in which the sample solution flows out of the open tip of the capillary, the second electrode being electrically isolated from the sample solution flowing in the capillary and applying an electric field to the sample solution flowing in the capillary, and an analyzer which analyzes a mass of gaseous ions formed from the sample solution sprayed by the gas flow.

摘要翻译： 一种质谱仪，包括样品溶液流过的通道，所述通道包括具有开口尖端的毛细管，所述样品溶液从毛细管的开口尖端流过毛细管，气体通道围绕开口形成气流 毛细管的尖端，气流喷射从毛细管的开口尖端流出的样品溶液，第一电极，其接触在通道中流动的样品溶液，并向在通道中流动的样品溶液施加电位，第二电极 设置在毛细管附近的毛细管周围的电极，第二电极相对于样品溶液在通道中流动的方向从第一电极下游，在毛细管的开口尖端的下游没有间隙 在样品溶液从毛细管的开口尖端流出的方向到第二电极，第二电极是电隔离的 从在毛细管中流动的样品溶液流出并向在毛细管中流动的样品溶液施加电场，以及分析器，其分析由气流喷射的样品溶液形成的气态离子的质量。

公开(公告)号：US6075243A

公开(公告)日：2000-06-13

申请号：US827184

申请日：1997-03-27

申请人： Takayuki Nabeshima ,  Minoru Sakairi ,  Yasuaki Takada ,  Yukiko Hirabayashi ,  Hideaki Koizumi

发明人： Takayuki Nabeshima ,  Minoru Sakairi ,  Yasuaki Takada ,  Yukiko Hirabayashi ,  Hideaki Koizumi

IPC分类号： G01N27/62 ,  G01N30/72 ,  H01J49/02 ,  H01J49/26 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/424 ,  H01J49/044 ,  H01J49/4255

摘要： A mass spectrometer in which, in order to reduce noise due to other particles (large charge droplets, neutral particles, photons, or the like), the orbit of ions and the orbit of other particles are separated from each other in the inside of a mass analysis region so as to make it possible to prevent the other particles from reaching an ion detection region without using any deflector.

摘要翻译： 一种质谱仪，其中为了减少由于其它颗粒（大电荷液滴，中性粒子，光子等）引起的噪声，离子的轨道和其它颗粒的轨道在一个 质量分析区域，使得可以防止其他颗粒在不使用任何偏转器的情况下到达离子检测区域。

公开(公告)号：US6060706A

公开(公告)日：2000-05-09

申请号：US23461

申请日：1998-02-13

申请人： Takayuki Nabeshima ,  Yasuaki Takada ,  Minoru Sakairi

发明人： Takayuki Nabeshima ,  Yasuaki Takada ,  Minoru Sakairi

IPC分类号： H01J49/06 ,  H01J49/42 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/424 ,  H01J49/061

摘要： In an analytical apparatus, an ion trap mass spectrometer and a detector for detecting ions separated in the mass spectrometer are installed in different chambers. Ions generated from an ion source and passing through two differential pumping chambers into a third chamber containing the detector are deflected from their initial trajectory into the mass spectrometer in a fourth chamber for separation. In a first embodiment, the separated ions are returned along the same path into the detector in the third chamber. According to a second embodiment, the detector is located along the path of ion travel beyond the mass spectrometer, and the separated ions pass through a second orifice in the mass spectrometer and into the detector in the third chamber.

摘要翻译： 在分析装置中，离子阱质谱仪和用于检测在质谱仪中分离的离子的检测器安装在不同的室中。 从离子源产生并且通过两个差分泵送室的包含检测器的第三室中的离子从第一个进入第四室的初始轨迹偏转到质谱仪中进行分离。 在第一实施例中，分离的离子沿相同的路径返回到第三室中的检测器中。 根据第二实施例，检测器沿着离子行进的路径位于质谱仪之外，并且分离的离子通过质谱仪中的第二孔并进入第三室中的检测器。

公开(公告)号：US06586730B1

公开(公告)日：2003-07-01

申请号：US09505428

申请日：2000-02-16

申请人： Seiji Kamimura ,  Isamu Takekoshi ,  Yasushi Terui ,  Yasuaki Takada ,  Takayuki Nabeshima ,  Minoru Sakairi

发明人： Seiji Kamimura ,  Isamu Takekoshi ,  Yasushi Terui ,  Yasuaki Takada ,  Takayuki Nabeshima ,  Minoru Sakairi

IPC分类号： H01J4900

CPC分类号： H01J49/282 ,  H01J49/04 ,  H01J49/42

摘要： A compact, easy-to-use device is provided which takes in a sample over a shorter distance, the sample introducing time is shortened, and contamination is prevented when the sample is introduced. A burner for generating a plasma, a deflecting portion provided with parallel electrodes for deflecting ions, and an analyzer room for performing mass separation of the deflected ions, these being disposed in a plane in the horizontal direction, and a sample setting portion for setting a sample, a peristaltic pump for aspirating the sample and the burner for introducing and burning the aspirated sample are disposed in a plane in the vertical direction relative to the aforesaid plane. The sample is supplied to the burner from below, and the ions generated by the plasma are made to flow on a horizontal plane.

摘要翻译： 提供了一种紧凑，易于使用的装置，其在较短距离内吸收样品，缩短了样品引入时间，并且在引入样品时防止污染。 用于产生等离子体的燃烧器，设置有用于偏转离子的平行电极的偏转部分和用于进行偏转离子的质量分离的分析器室，这些离子被设置在水平方向的平面中;以及样品设定部， 样品，抽吸样品的蠕动泵和用于引入和燃烧吸气样品的燃烧器相对于上述平面设置在垂直方向上的平面中。 将样品从下方供应到燃烧器，并且使由等离子体产生的离子在水平面上流动。

公开(公告)号：US06541769B1

公开(公告)日：2003-04-01

申请号：US09660359

申请日：2000-09-12

申请人： Yasuaki Takada ,  Yasushi Terui ,  Kiyomi Yoshinari ,  Takayuki Nabeshima ,  Minoru Sakairi

发明人： Yasuaki Takada ,  Yasushi Terui ,  Kiyomi Yoshinari ,  Takayuki Nabeshima ,  Minoru Sakairi

IPC分类号： B01D5944

CPC分类号： H01J49/424 ,  H01J49/061

摘要： An ion-deflecting device is located between a mass spectrometer and a detector, and undesired signal sources are prevented from reaching the detector during the ion-trapping period by switching the voltage applied to the detector between the ion-trapping period and the mass-analyzing period. A first voltage is applied to the detector during an ion-trapping period while a second voltage is applied to the detector during a mass-analyzing period. An ion-deflecting device deflects ions such that they do not reach the detector during an ion-trapping period while they do reach the detector during a mass-analyzing period. This way, the life of the detector is increased.

摘要翻译： 离子偏转装置位于质谱仪和检测器之间，并且在离子捕获期间通过切换在离子捕获期和质量分析之间施加到检测器的电压来防止不期望的信号源到达检测器 期。 在离子捕获期间将第一电压施加到检测器，同时在质量分析期间将第二电压施加到检测器。 离子偏转装置使离子偏转，使得它们在离子捕获期间不会在质量分析期间到达检测器时到达检测器。 这样，检测器的寿命就会增加。

公开(公告)号：US06423965B1

公开(公告)日：2002-07-23

申请号：US09378767

申请日：1999-08-23

申请人： Yuichiro Hashimoto ,  Takayuki Nabeshima ,  Yasuaki Takada ,  Minoru Sakairi ,  Masamichi Tsukada

发明人： Yuichiro Hashimoto ,  Takayuki Nabeshima ,  Yasuaki Takada ,  Minoru Sakairi ,  Masamichi Tsukada

IPC分类号： H01J4900

CPC分类号： H01J49/04

摘要： Plasma ion source mass spectrometers or liquid chromatograph/mass spectrometers are provided: wherein photon noises and matrix molecule ions produced by the ion source are decreased, the decrease of the quantity of signal is suppressed, and the apparatus maintenance is improved. The photon noises are decreased with a shielding plate and a 90 degrees deflector. The maintainability in cleaning is improved by a combination of a leading electrode, the shielding plate having a small hole, and a gate valve. The decrease in the quantity of signal is suppressed with the leading electrode, and a double cylindrical type static lens. Position adjustment of the leading electrode is performed with a flat plate having plural holes. Using an ion trap mass analyzer, matrix molecule ions are eliminated by applying a resonance voltage between its end cap electrodes. Decrease in the quantity of signals, which has been a problem, can be prevented, and a high transmission can be realized with a preferable reproducibility against disturbance of an electric field caused by ion lens and the like. A detectable limit of atomic ions of the sample can be improved by eliminating the matrix molecule ions.

摘要翻译： 提供了等离子体离子源质谱仪或液相色谱仪/质谱仪：其中由离子源产生的光子噪声和基质分子离子减少，抑制了信号量的减少，从而改善了设备的维护。 光子噪声随屏蔽板和90度偏转器而减小。 通过前导电极，具有小孔的屏蔽板和闸阀的组合来提高清洁的可维护性。 用前导电极和双圆柱形静电透镜抑制信号量的减少。 引导电极的位置调整用具有多个孔的平板进行。 使用离子阱质量分析仪，通过在其端盖电极之间施加谐振电压来消除基质分子离子。 可以防止已经存在问题的信号量的减少，并且以离子透镜等引起的电场干扰的优选再现性可以实现高透射率。 可以通过消除基质分子离子来改善样品的原子离子的可检测极限。