公开(公告)号：US3932668A

公开(公告)日：1976-01-13

申请号：US531415

申请日：1974-12-10

申请人： Yasuharu Sekizawa ,  Shigeo Seki ,  Bunzo Nomiya ,  Takemi Koeda ,  Fumio Kai ,  Naotoshi Akai ,  Yasushi Yusa ,  Fuguaki Fukuyasu

发明人： Yasuharu Sekizawa ,  Shigeo Seki ,  Bunzo Nomiya ,  Takemi Koeda ,  Fumio Kai ,  Naotoshi Akai ,  Yasushi Yusa ,  Fuguaki Fukuyasu

IPC分类号： A23K1/16 ,  A23K1/18 ,  A61K31/08

CPC分类号： A23K50/30 ,  A23K20/105

摘要： Novel alkyl 2,3,3-triiodoallyl ethers useful as disinfectants are provided by an addition reaction of alkyl-3-iodo-2-propinyl ethers with iodine. The starting alkyl-3-iodo-2-propinyl ethers can be prepared by a new process comprising an alkylation of propargyl alcohol with an alkyl sulfate or alkyl sulfonate in the presence of an alkali, followed by monoiodization of the resulting alkyl-2-propinyl ether. This invention also provides a composition comprising alkyl 2,3,3-triiodoalkyl ethers useful as a poultry feed additive having growth increasing effects and for treating swine scours.

摘要翻译： 用作消毒剂的新型烷基2,3,3-三碘代烯丙基醚通过烷基-3-碘-2-丙炔基醚与碘的加成反应来提供。 起始的烷基-3-碘-2-丙炔基醚可以通过一种新方法制备，该方法包括在碱存在下用炔丙醇与烷基硫酸盐或烷基磺酸盐烷基化，然后将所得的烷基-2-丙炔基 醚。 本发明还提供一种组合物，其包含可用作具有生长增加作用的禽饲料添加剂的烷基2,3,3-三碘烷基醚和用于治疗猪冲洗液的组合物。

公开(公告)号：US4029881A

公开(公告)日：1977-06-14

申请号：US345752

申请日：1973-03-28

申请人： Shigeharu Inouye ,  Shoji Omoto ,  Taro Niida ,  Bunzo Nomiya

发明人： Shigeharu Inouye ,  Shoji Omoto ,  Taro Niida ,  Bunzo Nomiya

IPC分类号： A01N43/22 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61P31/04 ,  C07H17/08

CPC分类号： C07H17/08 ,  A01N43/22

摘要： A new derivative of the macrolide antibiotic SF-837 substance is manufactured by treating a 9,2'-diacyl- or 9-acyl-SF-837 composition with dimethylsulfoxide and acetic anhydride, and, subsequently, with an alcohol or water-containing solvent to yield the novel compound, 9-Acyl-3"-thiomethoxymethyl-SF-837 composition. In addition to high therapeutic effectiveness and low acute toxicity, this novel compound of the present invention has the great advantages that it does not have the bitter taste originally accompanying the parent compounds, and the further advantage that it is suitable for pediatric and veterinary use.

摘要翻译： 通过用二甲基亚砜和乙酸酐处理9,2'-二酰基或9-酰基-SF-837组合物，然后用醇或含水溶剂来制备大环内酯类抗生素SF-837物质的新衍生物 得到新的化合物9-酰基-3“ - 硫代甲氧基甲基-SF-837组合物。 本发明的新型化合物除了具有高治疗效果和低急性毒性外，还具有不具有原始伴随母体化合物的苦味的优点，其优点在于适合于儿科和兽医用途。