公开(公告)号：US08142635B2

公开(公告)日：2012-03-27

申请号：US12843103

申请日：2010-07-26

申请人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

发明人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

IPC分类号： C02F1/40

CPC分类号： G01N27/44721 ,  G01N27/44782

摘要： A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.

摘要翻译： 毛细管阵列包括作为电泳所需功能的光检测部分，样品供应部分，缓冲溶液供应部分和电压施加部分，从而当将毛细管阵列组装到电泳装置中时可以立即使用。 因此，提供了可以容易地并入电泳装置中的毛细管阵列。

公开(公告)号：US07785458B2

公开(公告)日：2010-08-31

申请号：US11300377

申请日：2005-12-15

申请人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

发明人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

IPC分类号： C02F1/40

CPC分类号： G01N27/44721 ,  G01N27/44782

摘要： A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.

摘要翻译： 毛细管阵列包括作为电泳所需功能的光检测部分，样品供应部分，缓冲溶液供应部分和电压施加部分，从而当将毛细管阵列组装到电泳装置中时可以立即使用。 因此，提供了可以容易地并入电泳装置中的毛细管阵列。

公开(公告)号：US20100288642A1

公开(公告)日：2010-11-18

申请号：US12843103

申请日：2010-07-26

申请人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

发明人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

IPC分类号： G01N27/26

CPC分类号： G01N27/44721 ,  G01N27/44782

摘要： A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.

摘要翻译： 毛细管阵列包括作为电泳所需功能的光检测部分，样品供应部分，缓冲溶液供应部分和电压施加部分，从而当将毛细管阵列组装到电泳装置中时可以立即使用。 因此，提供了可以容易地并入电泳装置中的毛细管阵列。

公开(公告)号：US20060091012A1

公开(公告)日：2006-05-04

申请号：US11300377

申请日：2005-12-15

申请人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

发明人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

IPC分类号： C02F1/40

CPC分类号： G01N27/44721 ,  G01N27/44782

摘要： A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.

摘要翻译： 毛细管阵列包括作为电泳所需功能的光检测部分，样品供应部分，缓冲溶液供应部分和电压施加部分，从而当将毛细管阵列组装到电泳装置中时可以立即使用。 因此，提供了可以容易地并入电泳装置中的毛细管阵列。

公开(公告)号：US07005052B2

公开(公告)日：2006-02-28

申请号：US09845303

申请日：2001-05-01

申请人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

发明人： Yasushi Shimizu ,  Toshiaki Kita ,  Kiyoshi Tsukada ,  Akihiro Suzuki ,  Tomonari Morioka ,  Masaya Kojima ,  Ryoji Inaba ,  Daizo Tokinaga ,  Shuhei Yamamoto ,  Yoshiyuki Okishima ,  Masao Fukunaga ,  Takayasu Furukawa ,  Tomohiro Shoji

IPC分类号： G01N27/447 ,  C02F1/40

CPC分类号： G01N27/44721 ,  G01N27/44782

摘要： A capillary array includes a light detection portion, a sample supply portion, a buffer solution supply portion and a voltage application portion which are necessary functions for electrophoresis, thereby, when assembling the capillary array into an electrophoresis apparatus, the same can be immediately used. Accordingly, a capillary array is provided which can be easily incorporated into an electrophoresis apparatus.

公开(公告)号：US07054004B2

公开(公告)日：2006-05-30

申请号：US10704827

申请日：2003-11-12

申请人： Ryoji Inaba ,  Toshiaki Kita ,  Miho Ozawa ,  Tomonari Morioka ,  Akihiro Suzuki ,  Yasushi Shimizu ,  Masaya Kojima

发明人： Ryoji Inaba ,  Toshiaki Kita ,  Miho Ozawa ,  Tomonari Morioka ,  Akihiro Suzuki ,  Yasushi Shimizu ,  Masaya Kojima

IPC分类号： G01N21/00 ,  C02F1/40

CPC分类号： G01N27/44721 ,  G01N27/44782

摘要： A multi-focus capillary array that can reduce crosstalk and a capillary array photodetector are provided. On a substrate 20 on which a plurality of capillaries are aligned, a perforation 72 is formed in at least a part of an area in the rear of the capillaries when the capillary array is viewed from the photodetector.

公开(公告)号：US20050067285A1

公开(公告)日：2005-03-31

申请号：US10913517

申请日：2004-08-09

申请人： Ryoji Inaba ,  Miho Ozawa ,  Akihiro Suzuki ,  Daizo Tokinaga ,  Tomohiro Shoji ,  Yoshitaka Kodama ,  Isao Haraura ,  Masaya Kojima

发明人： Ryoji Inaba ,  Miho Ozawa ,  Akihiro Suzuki ,  Daizo Tokinaga ,  Tomohiro Shoji ,  Yoshitaka Kodama ,  Isao Haraura ,  Masaya Kojima

IPC分类号： G01N21/64 ,  G01N27/447 ,  G01N27/453

CPC分类号： G01N27/44782 ,  G01N27/44721

摘要： The present invention is related to the decrease of crosstalk, in which part of light emission from a specific capillary is overlayed on the light emission position of its adjoining capillaries and is detected as signal from adjacent capillaries. Study conducted by the inventor has found that the crosstalk contains at least the following components. The signal light from a capillary may propagate through an adjoining capillary or a plurality of capillaries, the reflection at the inner surface of the outer diameter of quartz capillary makes plural signal paths to the photodetector. The crosstalk component may be focused at a point at a predetermined distance from the center axis of the capillary. The present invention is aimed at the control of the range of image to be detected as the capillary signal among the images focused on the photodetector from the capillaries. The present invention may decrease the crosstalk by controlling the detection of the light emission from the adjacent capillaries.

摘要翻译： 本发明涉及串扰的减少，其中来自特定毛细管的光发射的一部分覆盖在其相邻的毛细管的发光位置上，并被检测为来自相邻毛细管的信号。 发明人进行的研究发现串扰至少包含以下组件。 来自毛细管的信号光可以通过邻接的毛细管或多个毛细管传播，石英毛细管的外径的内表面的反射使得到达光电检测器的多个信号路径。 串扰分量可以聚焦在距离毛细管的中心轴预定距离的点处。 本发明的目的在于控制从毛细管聚焦在光电检测器上的图像中的毛细管信号的被检测图像的范围。 本发明可以通过控制来自相邻毛细管的光发射的检测来减小串扰。

公开(公告)号：US20070175761A1

公开(公告)日：2007-08-02

申请号：US11714221

申请日：2007-03-06

申请人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Selichi Ugai ,  Eric Nordman

发明人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Selichi Ugai ,  Eric Nordman

IPC分类号： G01N27/00

CPC分类号： G01N27/44782 ,  G01N27/44721

摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.

公开(公告)号：US08246806B2

公开(公告)日：2012-08-21

申请号：US11714222

申请日：2007-03-06

申请人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai ,  Eric S. Nordman

发明人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai ,  Eric S. Nordman

IPC分类号： G01N27/453

CPC分类号： G01N27/44782 ,  G01N27/44721

摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.

摘要翻译： 电泳装置包括具有设置在阵列的毛细管之间的液体或固体的多毛细管阵列。 液体或固体的折射率高于空气的折射率，小于水的折射率，并减少了由毛细管散射的激光束的数量。 还提供了调节通过多毛细管阵列的毛细管的折射和反射的激发光束的方法，以减少激光束的强度损失并增加设置在毛细管中的各个样品的照射。

公开(公告)号：US20070158195A1

公开(公告)日：2007-07-12

申请号：US11714222

申请日：2007-03-06

申请人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai ,  Eric Nordman

发明人： Ryoji Inaba ,  Tomohiro Shoji ,  Shozo Kasai ,  Masaya Kojima ,  Yasushi Shimizu ,  Seiichi Ugai ,  Eric Nordman

IPC分类号： G01N27/00

CPC分类号： G01N27/44782 ,  G01N27/44721

摘要： An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than that of air and less than that of water and reduces the amount of laser beams scattered by the capillaries. Also provided are methods of adjusting refracted and reflected excitation light beams passing through capillaries of a multi-capillary array, to reduce loss of intensity of the laser beams and increase irradiation of respective samples disposed in the capillaries.