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38 条记录 (耗时 0.032 秒)

    Cyclohexane-1,2'-Naphthalene-1',2
    5.
    发明申请
    Cyclohexane-1,2'-Naphthalene-1',2"-Imidazol Compounds and Their Use as Bace 有权
    环己烷-1,2'-萘-1'，2“ - 咪唑化合物及其作为Bace的用途

    公开(公告)号：US20130345248A1

    公开(公告)日：2013-12-26

    申请号：US13916731

    申请日：2013-06-13

    申请人： Sofia Karlstrom ,  Lars Sandberg ,  Peter Soderman ,  Karin Kolmodin ,  Liselotte Ohberg

    发明人： Sofia Karlstrom ,  Lars Sandberg ,  Peter Soderman ,  Karin Kolmodin ,  Liselotte Ohberg

    IPC分类号： C07D235/02 ,  A61K45/06 ,  A61K31/4439 ,  A61K31/4184 ,  C07D401/04

    CPC分类号： C07D235/02 ,  A61K31/4184 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/02 ,  C07D401/04 ,  C07D491/107

    摘要： Cyclohexane-1,2′-naphthalene-1′,2″-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.

    摘要翻译： 环己烷-1,2'-萘-1'，2“ - 咪唑化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病， 阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹 或皮层基底变性，使用这些化合物的治疗方法，以及含有这些化合物的药物组合物。

    Locking sleeve package and blank therefor
    6.
    发明授权
    Locking sleeve package and blank therefor 有权
    锁紧套筒包装和空白

    公开(公告)号：US07389875B2

    公开(公告)日：2008-06-24

    申请号：US11019398

    申请日：2004-12-23

    申请人： Lars Sandberg ,  Marcus Dehlin ,  Antje Rosentreter

    发明人： Lars Sandberg ,  Marcus Dehlin ,  Antje Rosentreter

    IPC分类号： B65D83/04

    CPC分类号： B65D83/0463 ,  B65D5/38 ,  B65D2215/02

    摘要： A package includes a top panel, a bottom panel, a first side panel connecting the top panel and the bottom panel to each other and a second side panel also connecting the top panel and the bottom panel to each other. The bottom panel, the first side panel, the top panel and the second side panel form a sleeve having a cross-section essentially formed as a rectangle. The sleeve is adapted to slidably receive an insert along a sliding direction normal to the rectangle. The package includes a locking member which includes an arch-shaped portion extending into the rectangular cross section to releasably retain the insert. The present disclosure also relates to a blank for forming the package.

    摘要翻译： 包装包括顶板，底板，将顶板和底板彼此连接的第一侧板以及将顶板和底板相互连接的第二侧板。 底板，第一侧板，顶板和第二侧板形成具有基本上形成为矩形的横截面的套筒。 套筒适于沿着垂直于矩形的滑动方向可滑动地接收插入件。 该包装包括锁定构件，该锁定构件包括延伸到矩形横截面中以可释放地保持插入件的拱形部分。 本公开还涉及用于形成包装的坯料。

    Limitation of controllable operating parameters in an engine
    7.
    发明授权
    Limitation of controllable operating parameters in an engine 失效

    公开(公告)号：US06543397B2

    公开(公告)日：2003-04-08

    申请号：US09682799

    申请日：2001-10-19

    申请人： Lars Sandberg ,  Martin Litorell

    发明人： Lars Sandberg ,  Martin Litorell

    IPC分类号： F02D4102

    CPC分类号： F02D41/0235 ,  F02D41/1495 ,  F02D41/187 ,  F02D2011/102 ,  F02D2041/389

    摘要： The invention relates to a method for limitation of at least one controllable operating parameter that can cause ageing of at least one component or one material in connection with an engine. The method includes the steps of determination of a maximum limit value allowed regarding the operating parameter and control of the engine so that the limit value is not exceeded, thereby limiting ageing of the component or material. The invention includes continuous determination of a measure that corresponds to the degree of impairment of the component that depends on ageing, wherein said determination of the limit value is made depending on the measure. The invention also relates to an arrangement for accomplishing this method. By means of the invention, an improved method and arrangement is provided for limitation of ageing of components and materials that, in particular, are arranged in connection with a combustion engine in a vehicle, thereby providing improved fuel consumption, improved emissions and improved performance of the vehicle.