公开(公告)号：US07826982B2

公开(公告)日：2010-11-02

申请号：US11496959

申请日：2006-07-31

申请人： Yi Zheng ,  Nicolas Nassar ,  Karlheinz R. Skowronek

发明人： Yi Zheng ,  Nicolas Nassar ,  Karlheinz R. Skowronek

IPC分类号： G01N31/00 ,  G06G7/58

CPC分类号： C12N9/16 ,  A61K31/506 ,  C07K2299/00 ,  Y02A90/26

摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

摘要翻译： 优选的实施方案通常涉及影响Rho家族GTP酶，优选Rac（Rac1，Rac2和/或Rac3）成员的GTP-结合活性的方法和组合物，所述组合物包括调节GTP / GDP交换活性的化合物 用于化合物的用途，包括筛选识别Rac GTP酶的化合物，以及治疗与Rho家族GTP酶（包括Rac）相关或相关的病理状况的方法。 优选实施方案还涉及使用这些化合物或其衍生物的方法，例如在治疗学，诊断学和研究工具中。