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1.Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity 审中-公开
标题翻译: 用于治疗高增殖性疾病和与丝裂原细胞外激酶活性相关的疾病的取代的苯基氨基苯衍生物公开(公告)号:US20090082328A1
公开(公告)日:2009-03-26
申请号:US12151855
申请日:2008-05-09
申请人: Yingfu Li , Joachim Rudolph , Jacques P. Dumas , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther
发明人: Yingfu Li , Joachim Rudolph , Jacques P. Dumas , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther
IPC分类号: A61K31/445 , C07C205/45 , C07D211/32 , C07C255/58 , C07D317/30 , C07C237/28 , A61K31/397 , A61K31/40 , A61K31/27 , A61P35/00 , A61K31/44 , A61K31/166 , C07D295/14 , C07D279/12 , C07D265/30 , A61K31/54 , A61K31/5375
CPC分类号: C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译: 本发明涉及新的取代的苯基氨基苯化合物,含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍,作为唯一试剂或与其它活性成分组合的用途。
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2.SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY 审中-公开
标题翻译: 用于治疗与增殖细胞激酶活性相关的超增殖性疾病和疾病的替代苯甲酰苯胺衍生物公开(公告)号:US20110071125A1
公开(公告)日:2011-03-24
申请号:US12599641
申请日:2008-05-09
申请人: Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
发明人: Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
IPC分类号: A61K31/4178 , C12N9/99 , A61K31/397 , A61K31/535 , A61K31/4965 , A61K31/445 , A61K31/425 , A61K31/385 , A61K31/17 , A61K31/165 , C07D295/12 , C07D241/04 , C07D211/30 , C07D277/04 , C07D403/12 , C07D327/04 , C07C273/00 , C07C233/00 , A61P35/00 , A61P27/12
CPC分类号: C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要: This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译: 本发明涉及新的取代的苯基氨基苯化合物,含有这些化合物的药物组合物,以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍,作为唯一试剂或与其它活性成分组合的用途。
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公开(公告)号:US20120157453A1
公开(公告)日:2012-06-21
申请号:US13393111
申请日:2010-08-27
申请人: Ignacio Aliagas , Stefan Gradl , Janet Gunzner , Simon Mathieu , Joachim Rudolph , Zhaoyang Wen , Steven Mark Wenglowsky
发明人: Ignacio Aliagas , Stefan Gradl , Janet Gunzner , Simon Mathieu , Joachim Rudolph , Zhaoyang Wen , Steven Mark Wenglowsky
IPC分类号: A61K31/519 , A61K31/52 , C07D487/04 , C07D495/04 , C07D491/048 , A61P13/12 , A61P35/00 , A61P25/28 , A61P9/00 , A61P29/00 , A61P25/06 , A61P25/00 , C07D473/34 , A61K31/5377
CPC分类号: C07D487/04 , C07D491/04 , C07D495/04
摘要: Compounds of Formula II are useful for inhibition of Raf kinases. Methods of using compounds of Formula II and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译: 式II的化合物可用于抑制Raf激酶。 公开了使用式II化合物和其立体异构体,互变异构体,前药和其药学上可接受的盐在体外,原位和体内诊断,预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号:US20120157451A1
公开(公告)日:2012-06-21
申请号:US13393069
申请日:2010-08-27
申请人: Stefan Gradl , Joachim Rudolph , Li Ren
发明人: Stefan Gradl , Joachim Rudolph , Li Ren
IPC分类号: A61K31/519 , A61P13/12 , A61P35/00 , C07D487/04 , A61K31/5377
CPC分类号: C07D487/04
摘要: Compounds of Formula (I) are useful for inhibition of Raf kinases. Methods of using compounds of Formula (I) and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译: 式(I)的化合物可用于抑制Raf激酶。 公开了使用式(I)的化合物及其立体异构体,互变异构体及其药学上可接受的盐在体外,原位和体内诊断,预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号:US20070129288A1
公开(公告)日:2007-06-07
申请号:US10518600
申请日:2003-06-10
申请人: Thomas Lampe , Isabelle Adelt , Dieter Beyer , Nina Brunner , Rainer Endermann , Kerstin Ehlert , Heinz-Peter Kroll , Franz Nussbaum , Siegfried Raddatz , Joachim Rudolph , Guido Schiffer , Andreas Schumacher , Yolanda Canco-Grande , Martin Michels , Stefan Weigand
发明人: Thomas Lampe , Isabelle Adelt , Dieter Beyer , Nina Brunner , Rainer Endermann , Kerstin Ehlert , Heinz-Peter Kroll , Franz Nussbaum , Siegfried Raddatz , Joachim Rudolph , Guido Schiffer , Andreas Schumacher , Yolanda Canco-Grande , Martin Michels , Stefan Weigand
CPC分类号: C07D245/04 , A61K38/00 , C07K5/0812
摘要: The invention relates to antibacterial amide macrocycles, to methods for the production thereof, and to the use of the same for producing pharmaceuticals for the treatment and/or prophylaxis of illness, especially bacterial infections.
摘要翻译: 本发明涉及抗菌酰胺大环化合物,其生产方法及其用于制备用于治疗和/或预防疾病,特别是细菌感染的药物的用途。
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公开(公告)号:US20060264486A1
公开(公告)日:2006-11-23
申请号:US10555024
申请日:2004-04-28
申请人: Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
发明人: Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
IPC分类号: A61K31/422 , C07D413/02
CPC分类号: C07D403/12 , C07D209/08 , C07D401/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
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7.
公开(公告)号:US07964622B2
公开(公告)日:2011-06-21
申请号:US12508314
申请日:2009-07-23
申请人: Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
发明人: Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
IPC分类号: A61K31/425 , A61K31/42 , C07D417/00 , C07D277/20 , C07D498/00 , C07D263/30
CPC分类号: C07D403/12 , C07D209/08 , C07D401/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
摘要: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
摘要翻译: 本发明涉及吲哚乙酸衍生物及其在药物组合物中用于治疗疾病如糖尿病,肥胖症,高脂血症和动脉粥样硬化疾病的用途。 本发明还涉及可用于制备吲哚乙酸衍生物的中间体和制备方法。
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公开(公告)号:US20110092479A1
公开(公告)日:2011-04-21
申请号:US12920050
申请日:2009-02-27
申请人: Kateri A. Ahrendt , Alexandre J. Buckmelter , Jason De Meese , Jonas Grina , Joshua D. Hansen , Ellen R. Laird , Paul Lunghofer , David Moreno , Brad Newhouse , Li Ren , Jeongbeob Seo , Hongqi Tian , Steven M. Wenglowsky , Bainian Feng , Janet Gunzner , Kim Malesky , Simon Mathieu , Joachim Rudolph , Zhaoyang Wen , Wendy B. Young
发明人: Kateri A. Ahrendt , Alexandre J. Buckmelter , Jason De Meese , Jonas Grina , Joshua D. Hansen , Ellen R. Laird , Paul Lunghofer , David Moreno , Brad Newhouse , Li Ren , Jeongbeob Seo , Hongqi Tian , Steven M. Wenglowsky , Bainian Feng , Janet Gunzner , Kim Malesky , Simon Mathieu , Joachim Rudolph , Zhaoyang Wen , Wendy B. Young
IPC分类号: A61K31/437 , C07D471/04 , A61K31/5377 , A61K31/496 , A61P35/00 , A61P35/02 , A61P13/12
CPC分类号: C07D471/04 , C07C311/08
摘要: Compounds of Formula I are useful for inhibition of Raf kinases. Methods of using compounds of Formula I and stereoisomers, tautomers, prodrugs and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译: 式I化合物可用于抑制Raf激酶。 公开了使用式I化合物和立体异构体,互变异构体,前药和其药学上可接受的盐在体外,原位和体内诊断,预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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9.Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 失效
标题翻译: 茚基乙酸衍生物及其作为药剂,中间体和制备方法的用途公开(公告)号:US20100204472A1
公开(公告)日:2010-08-12
申请号:US12759328
申请日:2010-04-13
申请人: Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens
发明人: Louis-David Cantin , Soongyu Choi , Roger B. Clark , Martin F. Hentemann , Xin Ma , Joachim Rudolph , Sidney X. Liang , Christiana Akuche , Rico C. Lavoie , Libing Chen , Dyuti Majumdar , Philip L. Wickens
IPC分类号: C07D239/34 , C07D401/04 , C07D405/10 , C07D213/85 , C07D213/72 , C07D213/55 , C07D513/04 , C07D277/30 , C07D239/42
CPC分类号: C07D213/30 , C07C59/72 , C07C59/90 , C07C69/734 , C07C211/48 , C07C217/24 , C07C255/54 , C07C327/48 , C07C333/04 , C07C2602/08 , C07D209/08 , C07D213/63 , C07D213/83 , C07D213/84 , C07D215/20 , C07D231/12 , C07D239/26 , C07D239/42 , C07D239/46 , C07D239/47 , C07D239/52 , C07D249/06 , C07D249/08 , C07D261/20 , C07D263/32 , C07D263/56 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D285/08 , C07D307/42 , C07D307/79 , C07D333/16 , C07D405/04 , C07D417/04 , C07D513/04
摘要: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译: 本发明涉及可用于治疗疾病如糖尿病,肥胖症,高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。 本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。
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10.
公开(公告)号:US20080064734A1
公开(公告)日:2008-03-13
申请号:US11897620
申请日:2007-08-31
申请人: Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
发明人: Joachim Rudolph , Louis-David Cantin , Steven Magnuson , William Bullock , Ann-Marie Bullion , Libing Chen , Chih-Yuan Chuang , Sidney Liang , Dyuti Majumdar , Herbert Ogutu , Alan Olague , Ning Qi , Philip Wickens
IPC分类号: A61K31/415 , A61P3/04 , C07D231/10
CPC分类号: C07D231/38 , C07D401/04 , C07D403/12 , C07D413/12 , C07D471/04
摘要: The present invention relates to anilinopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.
摘要翻译: 本发明涉及苯胺基吡唑化合物,药物组合物和治疗糖尿病及相关疾病的方法。
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