-
公开(公告)号：US07446195B2
公开(公告)日：2008-11-04
申请号：US11505263
申请日：2006-08-16
申请人： Yongqi Deng , Lianyun Zhao , Gerald W. Shipps, Jr. , Patrick J. Curran , M. Arshad Siddiqui , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人： Yongqi Deng , Lianyun Zhao , Gerald W. Shipps, Jr. , Patrick J. Curran , M. Arshad Siddiqui , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号： C07D413/12 , C07D403/12 , C07D409/12 , C07D405/12
CPC分类号： C07D405/12 , C07D333/40 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译： 描述了细胞周期蛋白依赖性激酶2的抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
-
公开(公告)号：US07511063B2
公开(公告)日：2009-03-31
申请号：US11504869
申请日：2006-08-16
申请人： Yongqi Deng , Patrick J. Curran , Gerald W. Shipps, Jr. , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人： Yongqi Deng , Patrick J. Curran , Gerald W. Shipps, Jr. , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号： A61K31/47 , C07D215/14
CPC分类号： C07D409/04 , C07D215/48 , C07D215/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10
摘要： Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译： 描述了基于喹啉的细胞周期蛋白依赖性激酶2抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
-
公开(公告)号：US20080045568A1
公开(公告)日：2008-02-21
申请号：US11504869
申请日：2006-08-16
申请人： Yongqi Deng , Patrick J. Curran , Gerald W. Shipps , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人： Yongqi Deng , Patrick J. Curran , Gerald W. Shipps , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号： A61K31/4709 , A61K31/4706 , C07D215/38
CPC分类号： C07D409/04 , C07D215/48 , C07D215/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10
摘要： Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译： 描述了基于喹啉的细胞周期蛋白依赖性激酶2抑制剂，包括抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法，抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
-
公开(公告)号：US08211854B2
公开(公告)日：2012-07-03
申请号：US12688664
申请日：2010-01-15
IPC分类号： A61K31/54 , A61K31/519 , A61K31/535 , A01N43/90
CPC分类号： A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要翻译： 本发明提供使用吡唑并[1,5-a]嘧啶化合物抑制选自AKT，检查点激酶，极光激酶，Pim激酶和酪氨酸激酶的蛋白激酶的方法，以及治疗，预防，抑制或 使用这种化合物改善与蛋白激酶相关的一种或多种疾病。
-
公开(公告)号：US5447864A
公开(公告)日：1995-09-05
申请号：US120530
申请日：1993-09-14
申请人： Margaret P. Raybuck , Michael K. Kenrick , David A. Parry , Andrew L. Bertera , John G. Anson , Nicola M. Williamson
发明人： Margaret P. Raybuck , Michael K. Kenrick , David A. Parry , Andrew L. Bertera , John G. Anson , Nicola M. Williamson
CPC分类号： C12N15/1017 , C12M47/06 , C12N1/06 , Y10S435/803 , Y10S435/82 , Y10T436/2525 , Y10T436/25375 , Y10T436/255
摘要： A method of separating cell nuclei from cells comprises: treating a fluid containing whole cells so as to selectively lyse the cytoplasmic membrane together with a small proportion of the nuclear membranes but leaving a large proportion of the cell nuclei intact; applying the treated fluid to a membrane whereby a mesh of DNA from the lysed nuclei is formed on the surface and captures intact cell nuclei. A device for use in the method is described.
摘要翻译： 从细胞中分离细胞核的方法包括：处理含有全细胞的流体，以便与少量的核膜一起选择性裂解细胞质膜，但是留下大部分细胞核完整; 将处理的流体施加到膜上，由此在表面上形成来自裂解的核的DNA网，并捕获完整的细胞核。 描述了用于该方法的装置。
-
6.发明申请NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS 有权细胞周期调节因子的新型调节因子及其与检查点激酶抑制剂的组合使用公开(公告)号：US20110183933A1
公开(公告)日：2011-07-28
申请号：US12744021
申请日：2008-11-05
IPC分类号： A61K31/7072 , C07H19/06 , A61K31/7068 , A61P35/00 , A61P35/02
CPC分类号： C07H19/067 , C07H19/073
摘要： In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.
摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的式（V）嘧啶类似物作为细胞周期检查点的靶向基于机制的调节剂。 可以通过施用本发明的细胞周期检查点调节剂来治疗癌症和/或恶性肿瘤。 还讨论了细胞周期检查点调节剂与检查点激酶抑制剂的合适组合，以在癌细胞中产生协同凋亡。 本发明包括通过施用细胞周期检查点调节剂和检查点激酶抑制剂的组合，包含活化剂的药物组合物以及组合药物试剂盒来治疗癌症的方法。
-
公开(公告)号：US20100125068A1
公开(公告)日：2010-05-20
申请号：US12688664
申请日：2010-01-15
IPC分类号： A61K31/54 , C07D487/04 , C07D279/12 , C07D413/14 , A61K31/519 , A61K31/5377 , A61P35/00
CPC分类号： A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention provides methods for inhibiting protein kinases selected from the group consisting of AKT, Checkpoint kinase, Aurora kinase, Pim kinases, and tyrosine kinase using pyrazolo[1,5-a]pyrimidine compounds and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with protein kinases using such compounds.
摘要翻译： 本发明提供使用吡唑并[1,5-a]嘧啶化合物抑制选自AKT，检查点激酶，极光激酶，Pim激酶和酪氨酸激酶的蛋白激酶的方法，以及治疗，预防，抑制或 使用这种化合物改善与蛋白激酶相关的一种或多种疾病。
-
公开(公告)号：US5556598A
公开(公告)日：1996-09-17
申请号：US119649
申请日：1993-09-13
IPC分类号： B01D29/01 , B01D15/00 , B01D63/08 , B01J20/281 , B01L3/02 , G01N1/00 , G01N1/10 , G01N1/40 , G01N30/52 , G01N30/60 , G01N33/48 , G01N33/543 , G01N35/04 , G01N35/10
CPC分类号： B01J20/281 , B01D15/3804 , B01L3/0275 , G01N30/48 , G01N33/54366 , B01J2220/54 , G01N1/405 , G01N2030/527 , G01N2035/0434 , G01N2035/1053 , G01N2035/1055 , G01N30/60
摘要： A device for capturing a component present in a fluid 18 a pipette tip having a rearward end 15 adapted to be fitted on a micro-pipette, and a forward end 12 with a membrane 17, adapted to bind the component, extending across the pipette tip.
摘要翻译： 用于捕获存在于流体18中的组分的装置，具有适于装配在微量移液管上的后端15的移液管尖端以及具有膜17的前端12，其适于结合部件，延伸穿过移液管尖端 。
-
9.发明授权Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors 有权细胞周期检查点的调节剂及其与检查点激酶抑制剂的组合公开(公告)号：US08603998B2
公开(公告)日：2013-12-10
申请号：US12744021
申请日：2008-11-05
IPC分类号： A61K31/70 , C07H19/00 , A61K31/535 , C07D487/00
CPC分类号： C07H19/067 , C07H19/073
摘要： In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.
摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的式（V）嘧啶类似物作为细胞周期检查点的靶向基于机制的调节剂。 可以通过施用本发明的细胞周期检查点调节剂来治疗癌症和/或恶性肿瘤。 还讨论了细胞周期检查点调节剂与检查点激酶抑制剂的合适组合，以在癌细胞中产生协同凋亡。 本发明包括通过施用细胞周期检查点调节剂和检查点激酶抑制剂的组合，包含活化剂的药物组合物以及组合药物试剂盒来治疗癌症的方法。
-
10.发明申请FORMULATION CONTAINING CYCLIN-DEPENDENT KINASE INHIBITING COMPOUND AND METHOD OF TREATING TUMORS USING THE SAME 审中-公开含有CYCLIN依赖性激酶抑制化合物的制剂及使用该方法治疗肿瘤的方法公开(公告)号：US20100286038A1
公开(公告)日：2010-11-11
申请号：US12678320
申请日：2008-09-16
申请人： Valentyn Antochshuk , Anita Dabbara , Paul Kirschmeier , David A. Parry , Mohammed Shameen , Siu-Long Yao
发明人： Valentyn Antochshuk , Anita Dabbara , Paul Kirschmeier , David A. Parry , Mohammed Shameen , Siu-Long Yao
IPC分类号： A61K38/18 , A61K31/519 , A61P35/02 , A61P35/00
CPC分类号： A61K31/519 , A61K38/193 , A61K2300/00
摘要： This application discloses a novel formulation containing a 3-amino-4-substituted pyrazole derivative which has cyclin-dependent kinase inhibiting properties, and a method of treating tumors using the novel formulation.
摘要翻译： 本申请公开了含有具有细胞周期蛋白依赖性激酶抑制性质的3-氨基-4-取代的吡唑衍生物的新型制剂，以及使用该新制剂治疗肿瘤的方法。
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.045 秒)