-
公开(公告)号:US07446195B2
公开(公告)日:2008-11-04
申请号:US11505263
申请日:2006-08-16
申请人: Yongqi Deng , Lianyun Zhao , Gerald W. Shipps, Jr. , Patrick J. Curran , M. Arshad Siddiqui , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人: Yongqi Deng , Lianyun Zhao , Gerald W. Shipps, Jr. , Patrick J. Curran , M. Arshad Siddiqui , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号: C07D413/12 , C07D403/12 , C07D409/12 , C07D405/12
CPC分类号: C07D405/12 , C07D333/40 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译: 描述了细胞周期蛋白依赖性激酶2的抑制剂,包括抑制剂的组合物,以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法,抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
-
公开(公告)号:US07511063B2
公开(公告)日:2009-03-31
申请号:US11504869
申请日:2006-08-16
申请人: Yongqi Deng , Patrick J. Curran , Gerald W. Shipps, Jr. , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人: Yongqi Deng , Patrick J. Curran , Gerald W. Shipps, Jr. , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号: A61K31/47 , C07D215/14
CPC分类号: C07D409/04 , C07D215/48 , C07D215/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10
摘要: Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译: 描述了基于喹啉的细胞周期蛋白依赖性激酶2抑制剂,包括抑制剂的组合物,以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法,抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
-
公开(公告)号:US20080045568A1
公开(公告)日:2008-02-21
申请号:US11504869
申请日:2006-08-16
申请人: Yongqi Deng , Patrick J. Curran , Gerald W. Shipps , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
发明人: Yongqi Deng , Patrick J. Curran , Gerald W. Shipps , Lianyun Zhao , M. Arshad Siddiqui , Janeta Popovici-Muller , Jose S. Duca , Alan W. Hruza , Thierry O. Fischmann , Vincent S. Madison , Rumin Zhang , Charles W. McNemar , Todd W. Mayhood , William T. Windsor , Emma M. Lees , David A. Parry
IPC分类号: A61K31/4709 , A61K31/4706 , C07D215/38
CPC分类号: C07D409/04 , C07D215/48 , C07D215/50 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/10
摘要: Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease or disease symptoms. The invention also provides for methods of making CDK-2 inhibitor compounds, methods of inhibiting CDK-2, and methods for treating disease or disease symptoms.
摘要翻译: 描述了基于喹啉的细胞周期蛋白依赖性激酶2抑制剂,包括抑制剂的组合物,以及使用抑制剂和抑制剂组合物的方法。 包括它们的抑制剂和组合物可用于治疗疾病或疾病症状。 本发明还提供了制备CDK-2抑制剂化合物的方法,抑制CDK-2的方法以及治疗疾病或疾病症状的方法。
-
公开(公告)号:US07608643B2
公开(公告)日:2009-10-27
申请号:US11370005
申请日:2006-03-07
IPC分类号: A01N35/04 , A61K31/541 , A01N43/90 , A61K31/519 , A61K31/12 , C07D419/04 , C07D417/00
CPC分类号: A61K31/4743 , A61K45/06 , A61K2300/00
摘要: The present invention relates to compounds of Formula I or pharmaceutically acceptable salts or solvates thereof: The present invention provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.
摘要翻译: 本发明涉及式I化合物或其药学上可接受的盐或溶剂合物:本发明提供了包含这些化合物的组合物,其可用于治疗与KSP驱动蛋白活性相关的细胞增殖性疾病或病症并抑制KSP驱动蛋白活性。
-
公开(公告)号:US06274312B1
公开(公告)日:2001-08-14
申请号:US08999774
申请日:1997-12-10
IPC分类号: C12Q168
CPC分类号: C07K14/4702 , C07K14/4738
摘要: Purified genes encoding intracellular regulatory molecules from a human, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自人的细胞内调节分子的纯化基因,与其相关的试剂,包括纯化的蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
-
-
-
-