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公开(公告)号:US5940662A
公开(公告)日:1999-08-17
申请号:US801921
申请日:1997-02-14
申请人: Yoshifumi Hano , Shuichi Aita , Tsutomu Kukimoto , Tsuyoshi Takiguchi , Fumihiro Arahira , Yuji Ishihara , Kiyoshi Mizoe
发明人: Yoshifumi Hano , Shuichi Aita , Tsutomu Kukimoto , Tsuyoshi Takiguchi , Fumihiro Arahira , Yuji Ishihara , Kiyoshi Mizoe
IPC分类号: G03G15/02
CPC分类号: G03G15/0241 , G03G2215/022
摘要: A charging apparatus which comprises an electrophotographic photosensitive member and a charging member which comprises magnetic particles and placed in contact with the electrophotographic photosensitive member to charge the electrophotographic photosensitive member upon application of a voltage, wherein each magnetic particle has a surface layer containing a polyolefin resin of which weight average molecular weight is 10,000 or more, and has a volume resistivity of 1.times.10.sup.4 to 1.times.10.sup.11 .OMEGA.cm.
摘要翻译: 一种充电装置,其包括电子照相感光构件和充电构件,所述充电构件包括磁性颗粒并与电子摄影感光构件接触以在施加电压时对电子照相感光构件充电,其中每个磁性颗粒具有含有聚烯烃树脂的表面层 其重均分子量为10,000以上,体积电阻率为1×10 14〜1×10 11欧米高。
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公开(公告)号:US08517451B2
公开(公告)日:2013-08-27
申请号:US13639211
申请日:2011-04-07
IPC分类号: B62D35/00
摘要: A front underfloor structure of a vehicle includes front deflectors disposed forward of front tires, respectively. The front deflectors each include a front apex portion disposed at a position closer to the vehicle front than a leading edge surface of each of the front tires when straight, and disposed at a position closer to a vehicle center line than an inner surface of each of the front tires when straight; an outer end portion disposed at a position closer to the vehicle rear than the front apex portion, and disposed at a position outward in the vehicle width direction of the front apex portion; and a second flow redirection surface connecting the front apex portion and the outer end portion, and being configured such that, when struck by air traveling from the vehicle front, the second flow redirection surface redirects a flow of the traveling air outward in the vehicle.
摘要翻译: 车辆的前地板结构包括分别设置在前轮胎前方的前偏转器。 前导向器各自包括设置在比前轮胎的前边缘更靠近车辆前方的位置处的前顶部部分,其在直线时位于比每个前轮胎的内表面更靠近车辆中心线的位置 前轮胎直线时; 设置在比前顶点更靠近车辆后方的位置,并且设置在前顶点部的车宽方向外侧的位置; 以及连接前顶点部和外端部的第二流向重定向面,并且被构造成当从车辆前方行进的空气撞击时,第二流向重定向面将行进空气的流动重新引导到车辆外部。
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公开(公告)号:US08252814B2
公开(公告)日:2012-08-28
申请号:US12219198
申请日:2008-07-17
申请人: Yuji Ishihara , Takayuki Doi , Hiroshi Nagabukuro , Yuji Ishichi
发明人: Yuji Ishihara , Takayuki Doi , Hiroshi Nagabukuro , Yuji Ishichi
IPC分类号: A01N43/40 , A61K31/445
CPC分类号: A61K31/00 , A61K31/343 , A61K31/382 , A61K31/395 , A61K31/404 , A61K31/435 , A61K31/445 , A61K31/452 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/473 , A61K31/4745 , A61K31/55 , A61K31/553 , A61K45/06 , C07D211/26 , C07D211/32 , C07D273/06 , C07D401/06 , C07D471/06 , C07D487/04 , A61K2300/00
摘要: Agents for improving potency of the urinary bladder which comprise an amine compound of non-carbamate-type having an acetylcholinesterase-inhibiting action. Particularly, crystals of a tricyclic, condensed, heterocyclic derivative are provided, which possess an excellent action to inhibit acetylcholinesterase and an action to improve the excretory potency of the urinary bladder. As an example, crystals of 8-[3-[1-[(3-fluorophenyl)-methyl]-4-piperidinyl]-1-oxopropyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one or a salt thereof and pharmaceutical compositions containing them are disclosed.
摘要翻译: 用于提高膀胱效能的药剂,其包含具有乙酰胆碱酯酶抑制作用的非氨基甲酸酯型胺化合物。 特别地,提供三环,缩合,杂环衍生物的结晶,其具有抑制乙酰胆碱酯酶的优异作用和提高膀胱排泄能力的作用。 例如,8- [3- [1 - [(3-氟苯基) - 甲基] -4-哌啶基] -1-氧代丙基] -1,2,5,6-四氢-4H-吡咯并[ 2,1-ij]喹啉-4-酮或其盐和含有它们的药物组合物。
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公开(公告)号:US07903520B2
公开(公告)日:2011-03-08
申请号:US12078917
申请日:2008-04-08
申请人: Yuji Ishihara
发明人: Yuji Ishihara
IPC分类号: G11B7/0045
CPC分类号: G11B7/00456
摘要: An optical disc recorder that records information on an optical disc by means of a laser diode that forms pits in the optical disc through the application of a write pulse of a previously set type, the recorder having a reference power setter that sets a reference power that is the reference value of a drive power of the write pulse, a pulse type checker that checks whether the type of write pulse set consists of a plurality of pulses, which allows the drive power to be set for each pulse of a plurality of pulses, a power corrector for correcting the drive power of at least one pulse of the write pulse by adding a previously set correction power to the reference power, and a drive controller that applies the write pulse, which consists of the pulse with the reference power and the at least one pulse with the drive power corrected.
摘要翻译: 一种光盘记录器,其通过采用先前设定类型的写入脉冲在光盘中形成凹坑的激光二极管在光盘上记录信息,该记录器具有参考功率设定器,该参考功率设定器设定参考功率, 是写入脉冲的驱动功率的参考值,脉冲型检查器,其检查写入脉冲集合的类型是否由多个脉冲组成,这允许为多个脉冲的每个脉冲设置驱动功率, 功率校正器,用于通过将预先设定的校正功率与参考功率相加来校正写入脉冲的至少一个脉冲的驱动功率;以及驱动控制器,其施加由具有参考功率的脉冲和 至少有一个驱动功率被校正的脉冲。
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公开(公告)号:US20070199339A1
公开(公告)日:2007-08-30
申请号:US11703410
申请日:2007-02-07
CPC分类号: H02K9/20 , B60K1/02 , B60K7/0007 , B60K11/02 , B60K2001/003 , B60K2007/0038 , B60K2007/0092 , B60L2220/44 , B60L2240/425 , Y02T10/641 , Y02T10/642
摘要: A cooling apparatus for cooling a heat-generating member includes a cooling flow path, a condenser, a coolant-returning flow path, a first check valve and a second check valve. The cooling flow path is thermally connected to the heat-generating member. The condenser is connected to a downstream portion of the cooling flow path and condenses a coolant contained in the cooling apparatus after the coolant is evaporated in the cooling flow path. The coolant-returning flow path returns the coolant condensed by the condenser to an upstream portion of the cooling flow path. The first check valve is disposed between the coolant-returning flow path and prevents the coolant from flowing in a reverse direction from the cooling flow path to the first coolant-returning flow path. The second check valve is disposed between the condenser and the coolant-returning flow path and prevents the coolant from flowing in a reverse direction from the first coolant-returning flow path to the condenser.
摘要翻译: 用于冷却发热构件的冷却装置包括冷却流路,冷凝器,冷却剂返回流路,第一止回阀和第二止回阀。 冷却流路与发热部件热连接。 冷凝器连接到冷却流路的下游部分,并且在冷却剂在冷却流路中蒸发后冷凝包含在冷却装置中的冷却剂。 冷却剂返回流路将由冷凝器冷凝的冷却剂返回到冷却流路的上游部。 第一止回阀设置在冷却剂返回流路之间,并且防止冷却剂沿着从冷却流路到第一冷却剂返回流路的相反方向流动。 第二止回阀设置在冷凝器和冷却剂返回流路之间,并且防止冷却剂沿着与第一冷却剂返回流动路径相反的方向流动到冷凝器。
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公开(公告)号:US20060128690A1
公开(公告)日:2006-06-15
申请号:US10545120
申请日:2004-02-12
申请人: Yuji Ishihara , Makoto Kamata , Shiro Takekawa
发明人: Yuji Ishihara , Makoto Kamata , Shiro Takekawa
IPC分类号: A61K31/55 , A61K31/401 , A61K31/445
CPC分类号: C07D211/16 , A61K31/55 , C07C233/73 , C07C235/42 , C07D207/09 , C07D207/12 , C07D211/14 , C07D213/82 , C07D233/24 , C07D295/135
摘要: The present invention provides a compound represented by the formula wherein Ar1 is a cyclic group optionally having substituent(s); R is a hydrogen atom, an optionally halogenated C1-6 alkyl, a phenyl optionally having substituent(s) or a pyridyl optionally having substituent(s); Ra1, Ra2, Ra3 and Ra4 are the same or different and each is a hydrogen atom, an optionally halogenated C1-6 alkyl or the like; Ar is a monocyclic aromatic ring optionally having substituent(s); Y is an optionally halogenated alkylene group; and R1 and R2 are (1) the same or different and each is a hydrogen atom or a C1-6 alkyl, (2) R1 and R2 form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, or (3) R1 and Y form a nitrogen-containing heterocycle optionally having substituent(s) together with the adjacent nitrogen atom, and R2 is a hydrogen atom or a C1-6 alkyl; provided that when the nitrogen-containing heterocycle formed by R1 and R2 together with the adjacent nitrogen atom is a piperazine, or when R is a C1-4 alkyl, Ar1 is a cyclic group having substituent(s), or a salt thereof, having a melanin-concentrating hormone antagonistic action and useful as an agent for the prophylaxis or treatment of obesity and the like.
摘要翻译: 本发明提供由下式表示的化合物:其中Ar 1是任选具有取代基的环状基团; R是氢原子,任选卤代的C 1-6烷基,任选具有取代基的苯基或任选具有取代基的吡啶基; Ra 1,R 2,R 3,R 3和R 4相同或不同,各自为氢原子 ,任选卤代的C 1-6烷基等; Ar是任选具有取代基的单环芳环; Y是任选卤代的亚烷基; 且R 1和R 2均为(1)相同或不同,并且各自为氢原子或C 1-6烷基,( 2)R 1和R 2 2形成任选具有取代基的氮杂环与相邻的氮原子,或(3)R 1, Y和Y形成任选具有取代基的氮杂环与相邻的氮原子一起形成,R 2是氢原子或C 1-6 烷基; 条件是当由R 1和R 2与相邻氮原子一起形成的含氮杂环是哌嗪时,或当R是C 1〜 4个烷基,Ar 1是具有取代基的环状基团或其盐,其具有黑色素浓缩激素拮抗作用并且可用作预防或治疗的药剂 肥胖等。
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公开(公告)号:US20050209213A1
公开(公告)日:2005-09-22
申请号:US10493427
申请日:2002-10-24
申请人: Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
发明人: Yuji Ishihara , Makoto Kamata , Shiro Takekawa , Nobuhiro Suzuki , Koki Kato
IPC分类号: A61K31/4015 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , A61P3/04 , A61P5/04 , A61P25/22 , A61P25/24 , A61P43/00 , C07D215/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D413/02 , C07D41/02
CPC分类号: C07D401/06 , A61K31/47 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D215/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04
摘要: A compound, which has a melanin-concentrating hormone antagonistic action and useful as an agent for preventing or treating obesity, and which is represented by the formula: wherein Ar is a cyclic group optionally having substituent(s); X is a bond or a spacer having a main chain of 1 to 6 atoms; R1 and R2 are the same or different and each is a hydrogen atom or a hydrocarbon group optionally having substituent(s), or R1 and R2 may form, together with the adjacent nitrogen atom, a nitrogen-containing heterocycle optionally having substituent(s); Y is a divalent hydrocarbon group optionally having substituent(s) (except CO); R3 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); and ring A and ring B may further have substituents, and when ring B further has a substituent, the substituent may be linked to R1 to form a ring, or a salt thereof, or a prodrug thereof, is provided.
摘要翻译: 一种化合物,其具有黑色素浓集激素拮抗作用并且可用作预防或治疗肥胖症的药剂,并且其由下式表示:其中Ar是任选具有取代基的环状基团; X是具有1至6个原子的主链的键或间隔基; R 1和R 2相同或不同,各自为氢原子或任选具有取代基的烃基,或R 1〜 >和R 2可以与相邻的氮原子一起形成任选具有取代基的含氮杂环; Y是任选具有取代基(CO除外)的二价烃基; R 3是氢原子或任选具有取代基的烃基; 并且环A和环B可以进一步具有取代基,并且当环B还具有取代基时,取代基可以与R 1连接形成环,或其盐或其前药, 被提供。
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公开(公告)号:US06534496B1
公开(公告)日:2003-03-18
申请号:US09402806
申请日:1999-10-07
申请人: Yuji Ishihara , Yukio Fujisawa , Naoki Furuyama
发明人: Yuji Ishihara , Yukio Fujisawa , Naoki Furuyama
IPC分类号: A61K3155
CPC分类号: C07D401/06 , A61K31/4523 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4745 , A61K31/55 , A61K31/553 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/14
摘要: The object of the present invention is to provide a prophylactic and/or therapeutic drug for obesity and obesity-associated diseasestor diabetes with a reduced risk for central side effects and high universality in usage. Another object of the present invention is to provide a pharmaceutical composition comprising a compound of the following formula: wherein Ar represents phenyl which may be substituted and/or condensed; n represents an integer of 1 to 10; R represents hydrogen or a hydrocarbon group which may be substituted, which may not be the same in its n occurrences; R may be bound to either Ar or a substituent for Ar; Y represents an amino group which may be subsituted or a nitrogen-containing saturated heterocyclic group which may be substituted, or a salt thereof, which can be used for a thermogenic agent, an antiobesity agent, a lipolytic agent, or a prophylactic and/or treating drug for obesity-associated diseases.
摘要翻译: 本发明的目的是提供一种用于肥胖和肥胖相关疾病的糖尿病的预防和/或治疗药物,其具有降低的中枢副作用的风险和使用的高普遍性。 本发明的另一个目的是提供一种药物组合物,其包含下式的化合物:其中Ar表示可被取代和/或缩合的苯基; n表示1〜10的整数, R表示氢或可被取代的烃基,其在其n次可能不相同; R可以与Ar或Ar的取代基结合; Y表示可以取代的氨基或可被取代的含氮饱和杂环基或其盐,其可用于生热剂,抗肥胖剂,脂解剂或预防和/或 治疗肥胖相关疾病的药物。
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公开(公告)号:US4751140A
公开(公告)日:1988-06-14
申请号:US786796
申请日:1985-10-11
申请人: Yuji Ishihara
发明人: Yuji Ishihara
CPC分类号: G02B5/128 , E01F9/512 , Y10T428/251 , Y10T428/252 , Y10T428/26 , Y10T428/31507
摘要: In a high-brightness pavement marking sheet material, a continuous pattern of a multiplicity of protuberances and depressions is formed on the surface of a base sheet made of rubber, synthetic resin or the like and that glass microspheres are embedded in these protuberances and depressions in such a manner that a depth of embedding of these glass microspheres in the base sheet from the surface is randomly different one from another and a majority of the glass microspheres in these protuberances and depressions are partially exposed from the surface of the base sheet. An excellent initial brightness is obtained and brightness at a high level is continuously maintained despite wear of the base sheet.
摘要翻译: 在高亮度路面标记片材中,在由橡胶,合成树脂等制成的基片的表面上形成有多个突起和凹陷的连续图案,并且玻璃微球嵌入这些突起和凹陷中 使得这些玻璃微球从表面上嵌入到基片中的深度随机地不同,并且这些突起和凹陷中的大部分玻璃微球从基片的表面部分露出。 获得优异的初始亮度,并且尽管基片的磨损仍能够持续保持高水平的亮度。
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公开(公告)号:US08668243B2
公开(公告)日:2014-03-11
申请号:US13382467
申请日:2010-07-13
申请人: Satoshi Komiya , Kazuhito Sugimoto , Hirofumi Kondou , Yuichi Morinaka , Tomohiro Koyahata , Masato Inoue , Kenichiro Koizumi , Hitoshi Takagi , Yuji Ishihara , Kazuaki Nakajima
发明人: Satoshi Komiya , Kazuhito Sugimoto , Hirofumi Kondou , Yuichi Morinaka , Tomohiro Koyahata , Masato Inoue , Kenichiro Koizumi , Hitoshi Takagi , Yuji Ishihara , Kazuaki Nakajima
IPC分类号: B62D35/00
CPC分类号: B62D35/00 , B60Q1/0017
摘要: A vehicle boundary layer air flow control structure is provided with a vehicle body and a side view mirror. The vehicle body includes an exterior contoured surface with an air flow deflector. The side view mirror is attached to the vehicle body to provide a diagonally rearward direction to be viewed from a driver's seat. The air flow deflector has a downward air flow guiding surface provided in a vehicle body region of the exterior contoured surface of the vehicle body along which an air flow heading toward the side view mirror passes. The downward air flow guiding surface extends in an air flow direction of the air flow with respect to the side view mirror to divert the air flow underneath the side view mirror.
摘要翻译: 车辆边界层气流控制结构设置有车体和侧视镜。 车身包括具有空气导流板的外部轮廓表面。 侧视镜附接到车体以提供从驾驶员座椅观察的斜向后方向。 空气导流器具有设置在车身外部轮廓表面的车身区域中的朝向侧视镜通过的空气流的向下空气流引导表面。 向下的空气流引导表面相对于侧视镜在空气流的空气流动方向上延伸以转移侧视镜下面的空气流。
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