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1.发明授权公开(公告)号：US06339089B2
公开(公告)日：2002-01-15
申请号：US09132706
申请日：1998-08-12
IPC分类号： C07D23995
CPC分类号： C07D401/12 , C07D239/95 , C07D405/12 , C07D409/12 , C07D495/04
摘要： A pyrimidine nucleus-containing compound represented by the formula (I): wherein ring A represents the ring of the formula (a): in which R1 is a nitro group, an amino group, a substituted amino group or a halogen atom, or the ring of the formula (b): in which R1′ is the group such as an alkyl group or an alkenyl group; R2 to R5 independently represent the group such as an alkyl group or an alkenyl group; with the proviso that at least one of R2 to R5 is an alkenyl group, or acid addition salts thereof.
摘要翻译： 由式（I）表示的含嘧啶核的化合物：其中环A表示式（a）的环：其中R 1为硝基，氨基，取代的氨基或卤素原子，或 式（b）的环：其中R1'为烷基或烯基等基团; R2至R5独立地表示烷基或烯基等基团; 条件是R2至R5中的至少一个为烯基，或其酸加成盐。
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公开(公告)号：US5837687A
公开(公告)日：1998-11-17
申请号：US406053
申请日：1995-03-17
CPC分类号： C07K5/0819 , C07K5/0606 , C07K5/06086 , C07K5/06104 , C07K5/06113 , A61K38/00 , Y02P20/55
摘要： Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group; R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group, and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.
摘要翻译： 公开了由式（I）表示的氮杂肽衍生物：其中A表示直接键，α-氨基酸或二肽的残基; R1表示氢原子或末端氨基的保护基; R2表示苯基或被一个或两个取代基取代的苯基，所述取代基选自低级烷基，卤素原子，可被保护的羟基，硝基，可被保护的氨基和全卤代低级烷基 ; R3表示羟基或末端羧基的保护基及其盐，和包含式（I）所示的氮杂多肽衍生物或其盐的呼吸器官，哮喘和支气管痉挛的神经炎症的治疗剂 作为活性成分。
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公开(公告)号：US5965538A
公开(公告)日：1999-10-12
申请号：US138656
申请日：1998-08-24
CPC分类号： C07K5/0819 , C07K5/0606 , C07K5/06086 , C07K5/06104 , C07K5/06113 , A61K38/00 , Y02P20/55
摘要： Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group; R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group,and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.
摘要翻译： 公开了由式（I）表示的氮杂肽衍生物：其中A表示直接键，α-氨基酸或二肽的残基; R1表示氢原子或末端氨基的保护基; R2表示苯基或被一个或两个取代基取代的苯基，所述取代基选自低级烷基，卤素原子，可被保护的羟基，硝基，可被保护的氨基和全卤代低级烷基 ; R3表示羟基或末端羧基的保护基及其盐，和包含式（I）所示的氮杂多肽衍生物或其盐的呼吸器官，哮喘和支气管痉挛的神经炎症的治疗剂 作为活性成分。
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公开(公告)号：US06929280B2
公开(公告)日：2005-08-16
申请号：US10392132
申请日：2003-03-18
申请人： Mitsuo Yasuda , Yoshiharu Nakashima
发明人： Mitsuo Yasuda , Yoshiharu Nakashima
IPC分类号： B60R21/20 , B60R21/205 , B60R21/2165 , B60R21/217
CPC分类号： B29C65/06 , B29C66/112 , B29C66/1122 , B29C66/114 , B29C66/131 , B29C66/30223 , B29C66/532 , B29C66/54 , B29C66/543 , B29C66/71 , B29C66/712 , B29C66/7212 , B29C66/73921 , B29K2101/12 , B29L2031/3038 , B60R21/205 , B60R21/2165 , B60R21/217 , B29K2309/08 , B29K2023/10 , B29K2075/00 , B29K2023/12 , B29K2021/003
摘要： An airbag apparatus for an automobile includes an airbag case for accommodating an airbag in a folded condition, the airbag case being disposed behind a surface panel which is made of a thermoplastic resin material and provided within the automobile; a fracture-opening section of the surface panel, the fracture-opening section facing an opening of the airbag case and being defined by means of fracture grooves formed on an inside surface of the surface panel; at least one reinforcement plate member fixed to the inside surface of the surface panel in a region corresponding to the fracture-opening section; and a frame member surrounding the reinforcement plate member and fixed to the inside surface of the surface panel in a region surrounding the fracture-opening section. The frame member and the reinforcement plate member are each made of a thermoplastic resin material, and are fixed to the inside surface of the surface panel through vibration welding.
摘要翻译： 一种用于汽车的安全气囊装置包括一个用于在折叠状态下容纳气囊的气囊盒，该气囊外壳设置在由热塑性树脂材料制成并设置在汽车内的表面板的后面; 所述断面开口部分面对所述气囊外壳的开口，并且通过形成在所述表面板的内表面上的断裂槽来限定; 至少一个加强板构件，其在对应于所述断裂开口部分的区域中固定到所述表面板的内表面; 以及围绕所述加强板构件并围绕所述断裂开口部分的区域固定到所述表面板的内表面的框架构件。 框架构件和加强板构件均由热塑性树脂材料制成，并且通过振动焊接固定到表面板的内表面。
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公开(公告)号：US5349050A
公开(公告)日：1994-09-20
申请号：US838140
申请日：1992-02-18
申请人： Mitsuo Masaki , Masaki Uehara , Kenji Hirate , Yoshikazu Isowa , Yoshiaki Sato , Yoshiharu Nakashima
发明人： Mitsuo Masaki , Masaki Uehara , Kenji Hirate , Yoshikazu Isowa , Yoshiaki Sato , Yoshiharu Nakashima
IPC分类号： A61K38/00 , C07K5/02 , C07K5/103 , C07K5/117 , C07K7/16 , A61K31/34 , A61K31/02 , C07K5/10 , C07K7/06
CPC分类号： C07K5/0202 , C07K5/1013 , C07K5/1024 , C07K7/16 , A61K38/00
摘要： Disclosed is a novel peptide having one of the formulae: ##STR1## (A and B are the amino acids: wherein if A is D- or L-Pro, B is Hat or Cit;if A is D-Pro, B is D-Arg, andif B is D- or L-Arg, A is Sat, Pip, Aze or Arg)Asn-A-L- (D-)Pro-Arg- (Gly)n (A is Set, Thr or Ala, n is 1 or 0)A-Ser-Pip-Arg (A is Pro-Asn-, Asn- or Pro-) ##STR2## (A is cyclopentylcarbonyl, Pro or pGlu; B is Gly or .beta.-Ala, W is a hydrogen atom or a group having the formula:or a peptide having the formula: ##STR3## wherein A and B have the same meanings as mentioned above, respectively pGlu-Asn-Ser-A-B-(Gly)n (A is Aze, D- or L-Pro, Pip or Sat, B is D- or L-Arg, Cit, Hat, Lys or Orn, n is 1 or 0) andPro- (Ash)m-Set-L- (D-)Pro-Arg- (Gly) n (m and n are independently 0 or 1)their functional derivatives, and pharmaceutically acceptable salts thereof.
摘要翻译： 公开了具有下式之一的新肽：（A和B是氨基酸：其中如果A是D-或L-Pro，B是Hat或Cit;如果A是D-Pro，B是D -Arg，如果B为D-或L-Arg，A为Sat，Pip，Aze或Arg）Asn-AL-（D-）Pro-Arg-（Gly）n（A为Set，Thr或Ala，n （A为Pro-Asn-，Asn-或Pro-）A（A为环戊基羰基，Pro或pGlu; B为Gly或β-Ala，W为氢 原子或具有下式的基团：或具有下式的肽：其中A和B分别具有与上述相同的含义，分别为pGlu-Asn-Ser-AB-（Gly）n（A为Aze，D- 或L-Pro，Pip或Sat，B为D-或L-Arg，Cit，Hat，Lys或Orn，n为1或0）和Pro-（Ash）m-Set-L-（D- Arg-（Gly）n（m和n独立地为0或1）它们的官能衍生物及其药学上可接受的盐。
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公开(公告)号：US5112947A
公开(公告)日：1992-05-12
申请号：US509950
申请日：1990-04-16
申请人： Mitsuo Masaki , Masaki Uehara , Kenji Hirate , Yoshikazu Isowa , Yoshiaki Sato , Yoshiharu Nakashima
发明人： Mitsuo Masaki , Masaki Uehara , Kenji Hirate , Yoshikazu Isowa , Yoshiaki Sato , Yoshiharu Nakashima
CPC分类号： C07K5/0202 , C07K5/1013 , C07K5/1024 , C07K7/16 , A61K38/00
摘要： Disclosed is a novel peptide having one of the formulae: ##STR1## (A and B are the amino acids: wherein if A is D- or L-Pro, B is Har or Cit;if A is D-Pro, B is D-Arg, andif B is D- or L-Arg, A is Sar, Pip, Aze or Arg)Asn-A-L-(D-)Pro-Arg-(Gly).sub.n(A is Ser, Thr or Ala, n is 1 or 0)A-Ser-Pip-Arg(A is Pro-Asn-, Asn- or Pro-) ##STR2## (A is cyclopentylcarbonyl, Pro or pGlu; B is Gly or .beta.-Ala, W is a hydrogen atom or a group having the formula: or a peptide having the formula: ##STR3## wherein A and B have the same meanings as mentioned above, respectivelypGlu-Asn-Ser-A-B-(Gly).sub.n(A is Aze, D- or L-Pro, Pip or Sar, B is D- or L-Arg, Cit, Har, Lys or Orn, n is 1 or 0) andPro-(Asn).sub.m -Ser-L-(D-)Pro-Arg-(Gly).sub.n(m and n are independently 0 or 1)their functional derivatives, and pharmaceutically acceptable salts thereof.
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公开(公告)号：US06860505B2
公开(公告)日：2005-03-01
申请号：US09975665
申请日：2001-10-10
申请人： Mitsuo Yasuda , Yoshiharu Nakashima
发明人： Mitsuo Yasuda , Yoshiharu Nakashima
IPC分类号： B60R21/20 , B60R21/215 , B60R21/217 , B60R21/16
CPC分类号： B60R21/216 , B60R21/2165 , B60R2021/2172
摘要： An airbag device for a passenger seat for use in a vehicle like an automobile. Reinforcement ribs 12 of rectangular horizontal cross-section protrudently extend downward from the back side of a fracture-opening section 30 of the interior cover. Mounting holes 14 are formed at the predetermined intervals in the front and rear side walls 12a of the reinforcement ribs (in the longer direction). Hooks 36 mounted to the front and rear side edge surfaces 5b of the airbag case 5 (in the longer direction) are joined to the mounting holes via a mounted section 35 extending downward from hinge sections 34 of reinforcement plate members 33. The left and right side walls 12b of the reinforcement ribs 12 are spaced from the left and right side edges 5c of the airbag case by a predetermined distance, and fracture grooves 30a of the fracture-opening section are formed at the portions positions spaced at the predetermined intervals.
摘要翻译： 一种用于如汽车的车辆中的乘客座椅的气囊装置。 具有矩形水平横截面的加强肋12从内盖的断裂开口部分30的后侧突出地向下延伸。 在加强筋的前侧壁12a和后侧壁12a（沿较长的方向）上以预定间隔形成安装孔14。 安装在气囊盒5的前后侧缘部5b（长度方向）上的钩36经由从加强板构件33的铰链部34向下方延伸的安装部35与安装孔接合。左右 加强肋12的侧壁12b与安全气囊的左右侧边缘5c隔开预定的距离，并且在以预定间隔隔开的部分位置处形成断裂开口部的断裂槽30a。
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公开(公告)号：US06435542B2
公开(公告)日：2002-08-20
申请号：US09847550
申请日：2001-05-02
申请人： Yoshiharu Nakashima , Mitsuo Yasuda
发明人： Yoshiharu Nakashima , Mitsuo Yasuda
IPC分类号： B60R2120
CPC分类号： B60R21/2165 , B60R21/205 , B60R2021/2172
摘要： An airbag apparatus for a front passenger seat includes a fracture-opening section which is defined in an interior cover and is split into front and rear subsections upon inflation of an airbag, and front and rear reinforcement plate members fixedly attached to back surfaces of the front and rear subsections. Upper bent portions and lower bent portions are alternately formed at predetermined intervals at each of the mutually-opposed end portions of the front and rear reinforcement plate members such that a vertical step is formed between the upper bent portions and the lower bent portions. A projection tongue having an engagement hole is provided at the tip end of each upper bent portion. A projection engageable with the engagement hole is formed on the upper face of each lower bent portion. The mutually-opposed end portions of the front and rear reinforcement plate members are superposed and engaged with each other in such a manner that the projection tongues are located above the lower bent portions.
摘要翻译： 用于前乘客座椅的气囊装置包括限定在内盖中的断裂开口部分，并且在气囊膨胀时被分成前后分段，并且前后加强板部件固定地附接到前部的后表面 和后部分。 上弯曲部分和下弯曲部分在前后加强板构件的每个相互相对的端部处以预定间隔交替地形成，使得在上弯曲部分和下弯曲部分之间形成垂直台阶。 在每个上部弯曲部分的末端设置有具有接合孔的突出舌片。 在每个下弯曲部的上表面上形成有可与接合孔接合的突起。 前加强板构件和后加强板构件的相互相对的端部以突出舌片位于下弯曲部分上方的方式彼此重叠并接合。
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公开(公告)号：US07007970B2
公开(公告)日：2006-03-07
申请号：US10449135
申请日：2003-05-28
IPC分类号： B60R21/20
CPC分类号： B29C65/06 , B29C66/112 , B29C66/1122 , B29C66/114 , B29C66/131 , B29C66/30223 , B29C66/532 , B29C66/54 , B29C66/7392 , B29K2101/12 , B29L2031/3038 , B60R21/205 , B60R21/2165 , B60R2021/2172
摘要： An airbag apparatus for an automobile includes an airbag case for accommodating an airbag, a fracture-opening section of the surface panel, and a reinforcement frame member having a frame portion, at least one fracture-section reinforcement portion, and an edge reinforcement potion. The frame portion has an engagement portion to which the airbag case is connected. The fracture-section reinforcement portion is joined to the inside surface of the surface panel to cover and reinforce the fracture-opening section. The edge reinforcement portion is joined to the inside surface of the surface panel to cover and reinforce a surface panel portion surrounding the fracture-opening section.
摘要翻译： 一种用于汽车的气囊装置包括用于容纳气囊的气囊壳体，表面板的断裂部分和具有框架部分的加强框架构件，至少一个断裂部分加强部分和边缘加强部分。 框架部分具有连接气囊壳体的接合部分。 断裂部加强部分接合到表面板的内表面以覆盖和加强断裂开口部分。 边缘加强部分接合到表面板的内表面以覆盖和加强围绕断裂开口部分的表面板部分。
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公开(公告)号：US06299198B1
公开(公告)日：2001-10-09
申请号：US09256425
申请日：1999-02-23
申请人： Yoshiharu Nakashima , Mitsuo Yasuda
发明人： Yoshiharu Nakashima , Mitsuo Yasuda
IPC分类号： B60R2120
CPC分类号： B60R21/205 , B60R21/2165 , B60R21/2171 , B60R2021/21537 , B60R2021/2172
摘要： An airbag system is provided which has an instrument panel cover provided with a favorable appearance and enables to protect a passenger sitting on the front passenger seat at an instance of collision. To have such favorable appearance, the cover is combined by mold forming with a lid plate located opposite to an opening of an airbag case as a single unit. The lid plate is arranged having its outer edge decreased in the physical strength. While a main body of a lid plate reinforcement made of a metallic material is joined by thermal bonding to the back side of a region inside the outer edge of the lid plate, a hinge extending outward from the main body is fixedly joined by a bracket to the airbag case so that the hinge, when the airbag element accommodated in the airbag case inflates, can be bent upward to lift or open up the lid plate. Accordingly, the cover when broken out is prevented from generating sharp edges or scattering broken pieces.
摘要翻译： 提供一种具有良好外观的仪表板盖的气囊系统，能够在碰撞的情况下保护坐在乘客座椅上的乘客。 为了具有这种良好的外观，通过模具成型将盖与作为单个单元的安全气囊的开口相对的盖板组合。 盖板被布置成其外边缘的物理强度降低。 虽然由金属材料制成的盖板加强件的主体通过热粘结连接到盖板的外边缘内的区域的背面，但是从主体向外延伸的铰链通过支架固定地连接到 安全气囊壳体，使得当容纳在安全气囊壳体中的气囊元件膨胀时，铰链可以向上弯曲以提升或打开盖板。 因此，能够防止破裂时的盖产生尖锐的边缘或散开碎片。
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