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公开(公告)号：US08551741B2
公开(公告)日：2013-10-08
申请号：US12479010
申请日：2009-06-05
IPC分类号： C12P13/04
摘要： An L-amino acid is produced by culturing a bacterium of the Enterobacteriaceae family which has an L-amino acid-producing ability in a medium containing fatty acids as the carbon source, particularly fatty acids which have been subjected to emulsification or homogenization, to thereby produce and accumulate the L-amino acid in a culture medium; and collecting the L-amino acid from the culture medium.
摘要翻译： 通过在含有脂肪酸作为碳源的培养基中，特别是经过乳化或均化的脂肪酸培养具有L-氨基酸生产能力的肠杆菌科的细菌来生产L-氨基酸，由此 在培养基中产生并积累L-氨基酸; 并从培养基中收集L-氨基酸。
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公开(公告)号：US20090291478A1
公开(公告)日：2009-11-26
申请号：US12479010
申请日：2009-06-05
摘要： An L-amino acid is produced by culturing a bacterium of the Enterobacteriaceae family which has an L-amino acid-producing ability in a medium containing fatty acids as the carbon source, particularly fatty acids which have been subjected to emulsification or homogenization, to thereby produce and accumulate the L-amino acid in a culture medium; and collecting the L-amino acid from the culture medium.
摘要翻译： 通过在含有脂肪酸作为碳源的培养基中，特别是经过乳化或均化的脂肪酸培养具有L-氨基酸生产能力的肠杆菌科的细菌来生产L-氨基酸，由此 在培养基中产生并积累L-氨基酸; 并从培养基中收集L-氨基酸。
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3.发明申请MICROORGANISM PRODUCING AN AMINO ACID OF THE L-GLUTAMIC ACID FAMILY AND A METHOD FOR PRODUCING THE AMINO ACID 有权生产L-谷氨酸家族的氨基酸的微生物和生产氨基酸的方法公开(公告)号：US20100062497A1
公开(公告)日：2010-03-11
申请号：US12555124
申请日：2009-09-08
申请人： Seizaburo Shiraga , Noriko Murayama , Hiroshi Izui , Hisao Ito , Hisashi Yasueda , Yoshihiro Usuda , Kazuhiko Matsui
发明人： Seizaburo Shiraga , Noriko Murayama , Hiroshi Izui , Hisao Ito , Hisashi Yasueda , Yoshihiro Usuda , Kazuhiko Matsui
CPC分类号： C12P13/14 , C12N9/0008 , C12P13/10 , C12P13/24
摘要： A microorganism is cultured in a medium, and is able to produce one or two or more kinds of L-amino acids including L-glutamic acid, L-glutamine, L-proline, L-ornithine, L-citrulline and L-arginine, and is modified to increase α-ketoglutarate synthase activity. The L-amino acids are collected from the medium or the cells.
摘要翻译： 在培养基中培养微生物，能够生成L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-鸟氨酸，L-瓜氨酸和L-精氨酸等一种或两种以上的L-氨基酸， 并被修饰以增加α-酮戊二酸合酶活性。 从培养基或细胞收集L-氨基酸。
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4.发明授权Microorganism producing an amino acid of the L-glutamic acid family and a method for producing the amino acid 有权产生L-谷氨酸家族的氨基酸的微生物和产生氨基酸的方法公开(公告)号：US08080396B2
公开(公告)日：2011-12-20
申请号：US12555124
申请日：2009-09-08
申请人： Seizaburo Shiraga , Noriko Murayama , Hiroshi Izui , Hisao Ito , Hisashi Yasueda , Yoshihiro Usuda , Kazuhiko Matsui
发明人： Seizaburo Shiraga , Noriko Murayama , Hiroshi Izui , Hisao Ito , Hisashi Yasueda , Yoshihiro Usuda , Kazuhiko Matsui
CPC分类号： C12P13/14 , C12N9/0008 , C12P13/10 , C12P13/24
摘要： A microorganism is cultured in a medium, and is able to produce one or two or more kinds of L-amino acids including L-glutamic acid, L-glutamine, L-proline, L-ornithine, L-citrulline and L-arginine, and is modified to increase α-ketoglutarate synthase activity. The L-amino acids are collected from the medium or the cells.
摘要翻译： 在培养基中培养微生物，能够生成L-谷氨酸，L-谷氨酰胺，L-脯氨酸，L-鸟氨酸，L-瓜氨酸和L-精氨酸等一种或两种以上的L-氨基酸， 并被修饰以增加α-酮戊二酸合酶活性。 从培养基或细胞收集L-氨基酸。
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5.发明授权公开(公告)号：US07833761B2
公开(公告)日：2010-11-16
申请号：US12202476
申请日：2008-09-02
CPC分类号： C12N9/0008 , C12P13/06 , C12P13/08 , C12P13/222 , C12P13/227
摘要： A microorganism is provided which has an ability to produce an L-amino acid such as L-lysine, L-tryptophan, L-phenylalanine, L-valine, L-leucine, L-isoleucine and L-serine, and has been modified to increase the activity of pyruvate synthase or pyruvate:NADP+ oxidoreductase. This microorganism is cultured in a medium containing ethanol or an aliphatic acid as the carbon source to produce and accumulate the L-amino acid in the medium or cells, and the L-amino acid is collected from the medium or the cells.
摘要翻译： 提供了具有产生L-赖氨酸，L-色氨酸，L-苯丙氨酸，L-缬氨酸，L-亮氨酸，L-异亮氨酸，L-丝氨酸等L-氨基酸的能力的微生物， 增加丙酮酸合酶或丙酮酸：NADP +氧化还原酶的活性。 将该微生物在含有乙醇或脂肪酸作为碳源的培养基中培养，以在培养基或细胞中产生并积累L-氨基酸，从培养基或细胞收集L-氨基酸。
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公开(公告)号：US20100081180A1
公开(公告)日：2010-04-01
申请号：US12579594
申请日：2009-10-15
CPC分类号： C12P7/46
摘要： An organic acid is produced by allowing a bacterium which has an ability to produce an organic acid and has been modified so that expression of yidE gene is enhanced, or a product obtained by processing the bacterium, to act on an organic raw material in a reaction mixture containing carbonate ions, bicarbonate ions, or carbon dioxide gas to produce the organic acid, and collecting the organic acid.
摘要翻译： 有机酸是通过使具有生产有机酸的能力的细菌进行改性的，以使yidE基因的表达增强，或通过加工细菌获得的产物作用于反应中的有机原料 含有碳酸根离子，碳酸氢根离子或二氧化碳气体的混合物以产生有机酸，并收集有机酸。
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7.发明申请L-AMINO ACID-PRODUCING BACTERIUM AND A METHOD FOR PRODUCING AN L-AMINO ACID 有权L-氨基酸生产细菌和一种生产L-氨基酸的方法公开(公告)号：US20090246835A1
公开(公告)日：2009-10-01
申请号：US12055438
申请日：2008-03-26
CPC分类号： C07K14/245 , C12P13/04 , C12P13/08 , C12P13/22
摘要： An L-amino acid is produced by culturing a microorganism of the family Enterobacteriaceae which has the ability to produce an L-amino acid and which has been modified so as to increase the expression of the evgA gene, the gadE gene, and/or the ydeO gene. These genes encode a transcription factor involved in the EvgAS two-component system regulon. The culture takes place in a medium, and the L-amino acid is collected from the medium or cells.
摘要翻译： L-氨基酸是通过培养具有产生L-氨基酸的能力的肠杆菌科的微生物而产生的，该微生物被修饰以增加evgA基因，gadE基因和/或 ydeO基因。 这些基因编码参与EvgAS双组分系统调节子的转录因子。 培养物在培养基中进行，从培养基或细胞收集L-氨基酸。
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8.发明申请公开(公告)号：US20060234357A1
公开(公告)日：2006-10-19
申请号：US11422969
申请日：2006-06-08
CPC分类号： C12N9/0016 , C07H21/04 , C07K14/34 , C12N9/1007 , C12N9/22 , C12P13/04 , C12P21/00 , C12P21/02
摘要： The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacterium Corynebacterium glutamicum ssp. lactofermentum and methods of producing substances in organisms having enhanced or attenuated expression of these polypeptides and/or polynucleotides.
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公开(公告)号：US20100112647A1
公开(公告)日：2010-05-06
申请号：US12579577
申请日：2009-10-15
申请人： Yoshihiko Hara , Keita Fukui , Yoshinori Tajima , Kazue Kawamura , Yoshihiro Usuda , Kazuhiko Matsui
发明人： Yoshihiko Hara , Keita Fukui , Yoshinori Tajima , Kazue Kawamura , Yoshihiro Usuda , Kazuhiko Matsui
IPC分类号： C12P13/20 , C12N1/20 , C12N1/21 , C12P13/14 , C12P7/40 , C12P7/58 , C12P7/42 , C12P7/46 , C12P7/48 , C12P7/50
CPC分类号： C12P13/14 , C07K14/195 , C07K14/245 , C07K14/265 , C12P7/46 , C12P7/48 , C12P7/50 , C12P13/20
摘要： An acidic substance having a carboxyl group is produced by culturing in a medium a microorganism which has been modified to enhance expression of the ybjL gene, and collecting the acidic substance having a carboxyl group from the medium.
摘要翻译： 具有羧基的酸性物质是通过在培养基中培养已被改良以增强ybjL基因表达的微生物，并从培养基中收集具有羧基的酸性物质产生的。
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10.发明授权Polynucleotides encoding useful polypeptides in corynebacterium glutamicum ssp. lactofermentum 有权编码谷氨酸棒杆菌中有用多肽的多核苷酸 乳发酵公开(公告)号：US07468262B2
公开(公告)日：2008-12-23
申请号：US10439247
申请日：2003-05-16
CPC分类号： C12N9/0016 , C07H21/04 , C07K14/34 , C12N9/1007 , C12N9/22 , C12P13/04 , C12P21/00 , C12P21/02
摘要： The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacterium Corynebacterium glutamicum ssp. lactofermentum and methods of producing substances in organisms having enhanced or attenuated expression of these polypeptides and/or polynucleotides.
摘要翻译： 本发明提供了用作生物技术工具的新型多肽和多核苷酸，其特异性在棒状杆菌型谷氨酸棒杆菌（Corynebacterium glutamicum） 乳发酵和在这些多肽和/或多核苷酸具有增强或减弱的表达的生物体中产生物质的方法。
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