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14 条记录 (耗时 0.022 秒)

    Aqueous solution of water-soluble epoxy resin, solid obtained therefrom, and processes for producing these
    2.
    发明授权
    Aqueous solution of water-soluble epoxy resin, solid obtained therefrom, and processes for producing these 失效
    水溶性环氧树脂的水溶液，由其得到的固体，及其制造方法

    公开(公告)号：US06372825B1

    公开(公告)日：2002-04-16

    申请号：US09530600

    申请日：2000-05-09

    申请人： Yoshihisa Tomotaki ,  Takashi Kitajima ,  Keiichiro Ishikawa ,  Akihiro Nabeshima ,  Tomohiro Furuichi

    发明人： Yoshihisa Tomotaki ,  Takashi Kitajima ,  Keiichiro Ishikawa ,  Akihiro Nabeshima ,  Tomohiro Furuichi

    IPC分类号： C08K320

    CPC分类号： C08G59/5006

    摘要： The present invention provides an aqueous solution of an epoxy resin and a solid thereof, which is obtained by the following manner that an epoxy compound or a solution of the epoxy compound in organic solvent, and an amine compound of the formula (1), an aqueous solution thereof, a solution of the amine compound in organic solvent, or a solution thereof in a mixture of water and organic solvent, are mixed together so that the epoxy compound and the amine compound are reacted or polymerized to obtain a solution of an epoxy resin, to which water is added and heated to remove the organic solvent and unreacted amine compound, and a process for preparing the same NH2N(R1)(R2)  (1) wherein R1 and R2 are the same or different and each is alkyl having 1 to 6 carbon atoms, alkylene having 2 to 11 carbon atoms or a group represented by —R3—N(R4)—R5— which are formed when both are bonded, R3 and R5 are the same or different and each is alkylene having 1 to 6 carbon atoms, and R4 is alkyl having 1 to 6 carbon atoms or amino group.

    摘要翻译： 本发明提供环氧树脂及其固体的水溶液，其通过以下方式获得：环氧化合物或环氧化合物在有机溶剂中的溶液和式（1）的胺化合物，式 其水溶液，胺化合物在有机溶剂中的溶液或其在水和有机溶剂的混合物中的溶液混合在一起，使得环氧化合物和胺化合物反应或聚合以获得环氧树脂 树脂，向其中加入水并加热以除去有机溶剂和未反应的胺化合物，并且制备硅藻土R1和R2的方法相同或不同，各自为具有1至6个碳原子的烷基，亚烷基具有2至11个 碳原子或由-R 3-N（R 4）-R 5表示的基团，当两者都键合时，R3和R5相同或不同，并且各自是具有1至6个碳原子的亚烷基，R4是具有1个 至6个碳原子 或氨基。

    Hardener for epoxy resin and epoxy resin composition
    4.
    发明授权
    Hardener for epoxy resin and epoxy resin composition 失效
    环氧树脂和环氧树脂组合物的固化剂

    公开(公告)号：US06503967B1

    公开(公告)日：2003-01-07

    申请号：US09868325

    申请日：2001-06-18

    申请人： Takashi Kitajima ,  Akihiro Nabeshima

    发明人： Takashi Kitajima ,  Akihiro Nabeshima

    IPC分类号： C08K320

    CPC分类号： C08G59/56 ,  C08G59/4035

    摘要： A curing agent for epoxy resins, the curing agent containing as an active ingredient a compound represented by the formula (1) or a salt thereof and an amine compound or a salt thereof, the curing agent being characterized in that at least one of the compound represented by the formula (1) and the amine compound is a salt of thiocyanic acid; and an epoxy resin composition having the curing agent incorporated therein: NH2N(R1)(R2)  (1) wherein R1 and R2 are the same or different and each represents alkyl having 1 to 8 carbon atoms, aryl, a nitrogen-containing heterocyclic group or when taken together, represents alkylene having 2 to 11 carbon atoms or a group represented by —R3—R4—R5— wherein R3 and R5 are the same or different and each represents alkylene having 1 to 8 carbon atoms, and R4 is an oxygen atom, a sulfur atom or a group ═NR6 or ═NNH2, wherein R6 is a hydrogen atom or alkyl having 1 to 8 carbon atoms.

    摘要翻译： 一种环氧树脂固化剂，所述固化剂含有作为活性成分的式（1）表示的化合物或其盐和胺化合物或其盐，所述固化剂的特征在于，所述化合物 由式（1）表示，胺化合物是硫氰酸盐; 和其中包含固化剂的环氧树脂组合物：其中R1和R2相同或不同，并且各自表示具有1至8个碳原子的烷基，芳基，含氮杂环基或者一起表示具有2〜 11个碳原子或由-R3-R4-R5-表示的基团，其中R3和R5相同或不同，并且各自表示具有1至8个碳原子的亚烷基，R4是氧原子，硫原子或基团= NR6 或= NNH 2，其中R 6是氢原子或具有1至8个碳原子的烷基。

    Artificial Blood Vessel
    5.
    发明申请
    Artificial Blood Vessel 审中-公开
    人造血管

    公开(公告)号：US20080281408A1

    公开(公告)日：2008-11-13

    申请号：US11574538

    申请日：2005-08-29

    申请人： Makoto Kodama ,  Takashi Kitajima

    发明人： Makoto Kodama ,  Takashi Kitajima

    IPC分类号： A61F2/82

    CPC分类号： A61L27/34 ,  A61L27/507 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/252 ,  A61L2300/414 ,  C08L77/04 ,  C08L75/04

    摘要： It is an object of the present invention to retain on an artificial blood vessel material an endothelial cell growth-promoting agent, for example the angiogenic factor HGF, without impairing its activity, thereby providing an artificial blood vessel having the function of promoting endothelialization. Such an object can be attained by an artificial blood vessel that includes a porous tubular structure formed from, for example, polytetrafluoroethylene and, layered and immobilized in sequence onto at least the inner surface thereof, (1) a polyamino acid urethane copolymer, (2) collagen or gelatin, and (3) an endothelial cell growth-promoting agent having collagen-binding activity. Preferred examples of the endothelial cell growth-promoting agent include a fusion protein of a polypeptide having collagen-binding activity such as, for example, a fibronectin-derived polypeptide and an angiogenic factor, in particular, HGF.

    摘要翻译： 本发明的目的是在人造血管材料上保留内皮细胞生长促进剂，例如血管生成因子HGF，而不损害其活性，从而提供具有促进内皮化功能的人造血管。 这样的目的可以通过人造血管来实现，该人造血管包括由例如聚四氟乙烯形成的多孔管状结构，并且至少在其内表面依次分层固定，（1）聚氨基酸氨基甲酸酯共聚物，（2 ）胶原或明胶，和（3）具有胶原结合活性的内皮细胞生长促进剂。 内皮细胞生长促进剂的优选实例包括具有胶原结合活性的多肽的融合蛋白，例如来自纤连蛋白的多肽和血管生成因子，特别是HGF。

    Trimeric chimera protein and collagen matrix containing chimera protein
    7.
    发明授权
    Trimeric chimera protein and collagen matrix containing chimera protein 有权
    含嵌合嵌合蛋白和含有嵌合体蛋白的胶原基质

    公开(公告)号：US06277600B1

    公开(公告)日：2001-08-21

    申请号：US09391001

    申请日：1999-09-07

    申请人： Masahiro Tomita ,  Takashi Kitajima

    发明人： Masahiro Tomita ,  Takashi Kitajima

    IPC分类号： C12P2104

    CPC分类号： C07K14/78 ,  A61K47/6435 ,  C07K2319/00

    摘要： Provision of a trimeric chimera protein which has sufficiently retained physiological activity of a physiologically active peptide simultaneously with fibril-forming ability of a collagen. A trimeric chimera protein comprising a collagen and a biologically active peptide fused to the collagen, wherein the biologically active peptide is fused on the side of the amino terminal of the collagen, and the collagen is a fibril-forming collagen having a triple helical structure in its triple helix region.

    摘要翻译： 提供具有充分保留生理活性肽的生理活性的三聚嵌合体蛋白质，同时具有胶原蛋白的原纤维形成能力。 包含与胶原融合的胶原蛋白和生物活性肽的三聚体嵌合体蛋白质，其中所述生物活性肽融合在胶原蛋白的氨基末端侧，并且胶原蛋白是具有三重螺旋结构的原纤维形成性胶原蛋白 其三螺旋区域。

    AGENT FOR REDUCTION OF BLEEDING IN CEREBROVASCULAR DISORDER
    10.
    发明申请
    AGENT FOR REDUCTION OF BLEEDING IN CEREBROVASCULAR DISORDER 审中-公开
    用于减少脑血管疾病发生的代理

    公开(公告)号：US20090226412A1

    公开(公告)日：2009-09-10

    申请号：US11993917

    申请日：2006-06-23

    申请人： Tetsuya Yasuhiro ,  Takashi Kitajima ,  Daisuke Wakamatsu ,  Wataru Kamoshima

    发明人： Tetsuya Yasuhiro ,  Takashi Kitajima ,  Daisuke Wakamatsu ,  Wataru Kamoshima

    IPC分类号： A61K38/49 ,  C07D413/12 ,  A61K31/5377 ,  A61P7/04

    CPC分类号： A61K45/06 ,  A61K31/5377

    摘要： The present invention relates to a hemorrhage reducing agent in cerebrovascular disorder containing a poly (ADP-ribose) polymerase inhibitor (PARP inhibitor). The PARP inhibitor provides an inhibitory effect of vascular endothelial cell disorder so that it may reduce hemorrhage in cerebrovascular disorder. In addition, the PARP inhibitor inhibits the hemorrhage that is concerned about in thrombolytic agent use by using together with a thrombolytic agent, and an effect of extending therapeutic time window of a thrombolytic agent may be further expected. Furthermore, the PARP inhibitor can be a safe hemorrhage reducing agent with fewer side effects because it does not affect the blood coagulation system and the fibrinolytic system.

    摘要翻译： 本发明涉及含有聚（ADP-核糖）聚合酶抑制剂（PARP抑制剂）的脑血管障碍的出血减少剂。 PARP抑制剂提供血管内皮细胞病症的抑制作用，以减少脑血管障碍的出血。 此外，PARP抑制剂通过与血栓溶解剂一起使用来抑制血栓溶解剂使用中涉及的出血，并且可以进一步预期延长溶栓剂的治疗时间窗口的效果。 此外，PARP抑制剂可以是具有较少副作用的安全性出血减少剂，因为它不影响凝血系统和纤维蛋白溶解系统。