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公开(公告)号:US20130071467A1
公开(公告)日:2013-03-21
申请号:US13492594
申请日:2012-06-08
申请人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
发明人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
IPC分类号: A61K9/127 , A61K31/713
CPC分类号: A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要: What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
摘要翻译: 描述的是包含包含有义链和反义链的双链核酸分子的药物组合物,其中有义链和反义链选自描述为SERPINH1_2的寡核苷酸(SEQ ID NO:60和127),SERPINH1_45a(SEQ ID NO: NOS:98和165)和SERPINH1_51(SEQ ID NO:101和168)和包含类视黄醇和脂质囊泡的混合物的药物载体,以及使用这些药物组合物治疗与hsp47表达相关的疾病的方法,包括 纤维化。
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公开(公告)号:US08741867B2
公开(公告)日:2014-06-03
申请号:US13492594
申请日:2012-06-08
申请人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
发明人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
IPC分类号: C12N15/11
CPC分类号: A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要: What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1_2 (SEQ ID NOS: 60 and 127), SERPINH1_45a (SEQ ID NOS: 98 and 165), and SERPINH1_51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 expression, including fibrosis.
摘要翻译: 描述的是包含包含有义链和反义链的双链核酸分子的药物组合物,其中有义链和反义链选自描述为SERPINH1_2的寡核苷酸(SEQ ID NO:60和127),SERPINH1_45a(SEQ ID NO: NOS:98和165)和SERPINH1_51(SEQ ID NO:101和168)和包含类视黄醇和脂质囊泡的混合物的药物载体,以及使用这些药物组合物治疗与hsp47表达相关的疾病的方法,包括 纤维化。
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3.
公开(公告)号:US20130071478A1
公开(公告)日:2013-03-21
申请号:US13492639
申请日:2012-06-08
申请人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
发明人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
IPC分类号: C07H21/02
CPC分类号: A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要: What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1—2 (SEQ ID NOS: 60 and 127), SERPINH1—45a (SEQ ID NOS: 98 and 165), and SERPINH1—51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.
摘要翻译: 所描述的是包含包含有义链和反义链的双链核酸分子的药物组合物,其中有义链和反义链选自描述为SERPINH1-2(SEQ ID NO:60和127)的寡核苷酸,SERPINH1- 45a(SEQ ID NO:98和165)和SERPINH1-51(SEQ ID NO:101和168)和包含类视黄醇和脂质囊泡的混合物的药物载体,以及使用这些药物组合物治疗疾病的方法 与hsp47浓缩相关,包括纤维化。
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4.
公开(公告)号:US08664376B2
公开(公告)日:2014-03-04
申请号:US13492639
申请日:2012-06-08
申请人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
发明人: Yoshiro Niitsu , Victor Knopov , Joseph E. Payne , Richard P. Witte , Mohammad Ahmadian , Loren A. Perelman , Violetta Akopian , Yasunobu Tanaka , Elena Feinstein , Sharon Avkin-Nahum , Hagar Kalinski , Igor Mett , Kenjiro Minomi , Wenbin Ying , Yun Liu
IPC分类号: C07H21/04
CPC分类号: A61K9/1271 , A61K9/127 , A61K31/713 , C07H21/02 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2320/52
摘要: What is described are pharmaceutical compositions comprising a double-stranded nucleic acid molecule comprising a sense strand and an antisense strand wherein the sense and antisense strands are selected from the oligonucleotides described as SERPINH1—2 (SEQ ID NOS: 60 and 127), SERPINH1—45a (SEQ ID NOS: 98 and 165), and SERPINH1—51 (SEQ ID NOS: 101 and 168), and drug carrier comprising a mixture of a retinoid and a lipid vesicle, and methods of using these pharmaceutical compositions to treat a disease associated with hsp47 espresssion, including fibrosis.
摘要翻译: 所描述的是包含包含有义链和反义链的双链核酸分子的药物组合物,其中有义链和反义链选自描述为SERPINH1-2(SEQ ID NO:60和127)的寡核苷酸,SERPINH1- 45a(SEQ ID NO:98和165)和SERPINH1-51(SEQ ID NO:101和168)和包含类视黄醇和脂质囊泡的混合物的药物载体,以及使用这些药物组合物治疗疾病的方法 与hsp47浓缩相关,包括纤维化。
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