公开(公告)号：US5130126A

公开(公告)日：1992-07-14

申请号：US676384

申请日：1991-03-28

申请人： Yoshiyuki Koyama ,  Shuji Kojima ,  Tsuyoshi Miyazaki ,  Akinori Suginaka ,  Takeo Matsumoto ,  Yoshishige Murata

发明人： Yoshiyuki Koyama ,  Shuji Kojima ,  Tsuyoshi Miyazaki ,  Akinori Suginaka ,  Takeo Matsumoto ,  Yoshishige Murata

IPC分类号： A61K31/557 ,  A61K47/48

CPC分类号： A61K47/48215 ,  A61K31/557 ,  Y10S514/925

摘要： The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.

摘要翻译： 本发明提供了具有消化器官方向特性的聚合物组合药物，其中包含与具有亚烷基氧基作为重复单元的聚合物组合的药物。 通过使具有一个或多个末端官能团的聚氧亚烷基二醇和药物（如果需要在溶剂中）和必要时在催化剂存在下反应来制备聚合物组合药物。 能够口服给药或静脉注射，以保持血液中的浓度长时间稳定，并直接吸收或摄入消化器官如肠胃。

公开(公告)号：US20060193906A1

公开(公告)日：2006-08-31

申请号：US11350962

申请日：2006-02-10

申请人： Noboru Yamazaki ,  Shuji Kojima

发明人： Noboru Yamazaki ,  Shuji Kojima

IPC分类号： A61K9/127 ,  A61K38/37 ,  A61K31/739

CPC分类号： A61K8/14 ,  A61K9/1271 ,  A61K9/1272 ,  A61K47/6911 ,  A61Q19/00

摘要： The present invention provides a sugar-modified liposome having a sugar chain bonded to its membrane surface, preferably through a linker protein, and having excellent absorption qualities, particularly in the intestine. The molecular structure and quantity of the sugar chain is selectively varied to allow the liposome to be delivered in a targeted manner to selected cells and tissues. The liposome is applicable to medicinal drugs, cosmetics and other various products in the medical/pharmaceutical fields, and it is especially useful in a therapeutic drug delivery system that recognizes target cells and tissues, such as cancer cells, and in the delivery of drugs or genes locally to a selected region, or in a diagnostic cell/tissue sensing probe.

公开(公告)号：US08631701B2

公开(公告)日：2014-01-21

申请号：US13225869

申请日：2011-09-06

申请人： Seiichi Chiba ,  Shuji Kojima ,  Toshiyuki Enta ,  Akinori Shindo ,  Terunao Hanaoka ,  Yasuo Yamasaki

发明人： Seiichi Chiba ,  Shuji Kojima ,  Toshiyuki Enta ,  Akinori Shindo ,  Terunao Hanaoka ,  Yasuo Yamasaki

IPC分类号： G01C19/56

CPC分类号： G01P15/097 ,  B81B7/0006 ,  G01C19/5783 ,  H01L2224/48091 ,  H01L2924/00014

摘要： A sensor device includes a first electrode disposed on active surface side of a silicon substrate, an external connecting terminal electrically connected to the first electrode, at least one stress relaxation layer disposed between the silicon substrate and the external connecting terminal, a connecting terminal disposed on the active surface side of the silicon substrate, and a vibration gyro element having weight sections as mass adjustment sections, the vibration gyro element is held by the silicon substrate due to connection between the connection electrode and the external connecting terminal, and a meltage protection layer formed in an area where the stress relaxation layer and the mass adjustment section overlap each other in a plan view is provided.

摘要翻译： 传感器装置包括设置在硅衬底的有源表面侧的第一电极，与第一电极电连接的外部连接端子，设置在硅衬底和外部连接端子之间的至少一个应力松弛层， 硅衬底的有源表面侧和具有作为质量调节部分的重量部分的振动陀螺元件，由于连接电极和外部连接端子之间的连接，振动陀螺元件由硅衬底保持，并且熔融保护层 形成在应力松弛层和质量调节部在平面图中彼此重叠的区域中。

公开(公告)号：US08749001B2

公开(公告)日：2014-06-10

申请号：US13228989

申请日：2011-09-09

申请人： Terunao Hanaoka ,  Akinori Shindo ,  Yasuo Yamasaki ,  Seiichi Chiba ,  Toshiyuki Enta ,  Shuji Kojima

发明人： Terunao Hanaoka ,  Akinori Shindo ,  Yasuo Yamasaki ,  Seiichi Chiba ,  Toshiyuki Enta ,  Shuji Kojima

IPC分类号： H01L21/00 ,  G01P15/097

CPC分类号： H01L27/0207 ,  G01C19/5769 ,  G01C19/5783

摘要： An electronic component includes: a semiconductor element including a circuit; a vibration element; a first electrode arranged on a first surface of the semiconductor element and connected to the circuit and the vibration element arranged on the first surface side; a second electrode arranged on the first surface; a first wiring board including a first wire connected to the second electrode; and a second wiring board including a second wire to which the first wire is connected. At least a part of an inner side region of an outer contour of the vibration element is arranged to overlap the second electrode in plan view facing the first surface.

摘要翻译： 电子部件包括：包括电路的半导体元件; 振动元件 布置在所述半导体元件的第一表面上并连接到所述电路的第一电极和布置在所述第一表面侧上的所述振动元件; 布置在所述第一表面上的第二电极; 第一布线板，包括连接到第二电极的第一线; 以及第二配线基板，包括连接有第一配线的第二配线。 振动元件的外轮廓的内侧区域的至少一部分布置成在面向第一表面的平面图中与第二电极重叠。

公开(公告)号：US07070801B2

公开(公告)日：2006-07-04

申请号：US10352914

申请日：2003-01-29

申请人： Noboru Yamazaki ,  Shuji Kojima

发明人： Noboru Yamazaki ,  Shuji Kojima

IPC分类号： A61K9/127

CPC分类号： A61K8/14 ,  A61K9/1271 ,  A61K9/1272 ,  A61K47/549 ,  A61K47/62 ,  A61K47/6911 ,  A61Q19/00 ,  Y10T428/2984

摘要： The present invention provides a sugar-modified liposome having a sugar chain bonded to its membrane surface, preferably through a linker protein, and having excellent absorption qualities, particularly in the intestine. The molecular structure and quantity of the sugar chain is selectively varied to allow the liposome to be delivered in a targeted manner to selected cells and tissues. The liposome is applicable to medicinal drugs, cosmetics and other various products in the medical/pharmaceutical fields, and it is especially useful in a therapeutic drug delivery system that recognizes target cells and tissues, such as cancer cells, and in the delivery of drugs or genes locally to a selected region, or in a diagnostic cell/tissue sensing probe.