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11 条记录 (耗时 0.015 秒)

    Freeze-Dried Product for Introducing Nucleic Acid, Oligonucleic Acid or Derivative Thereof
    2.
    发明申请
    Freeze-Dried Product for Introducing Nucleic Acid, Oligonucleic Acid or Derivative Thereof 审中-公开
    用于引入核酸，寡核苷酸或其衍生物的冷冻干燥产品

    公开(公告)号：US20090130761A1

    公开(公告)日：2009-05-21

    申请号：US12227394

    申请日：2007-05-16

    申请人： Yoshiyuki Koyama ,  Tomoko Ito

    发明人： Yoshiyuki Koyama ,  Tomoko Ito

    IPC分类号： C12N15/87 ,  C12N5/06

    CPC分类号： C12N15/87 ,  A61K9/141 ,  A61K9/19 ,  A61K31/7088 ,  A61K47/542 ,  A61K47/543 ,  A61K47/59 ,  A61K47/60 ,  A61K47/61 ,  A61K47/6921 ,  A61K48/00 ,  A61K48/0091 ,  C12N15/1003 ,  C12N15/63

    摘要： A freeze-dried product is provided which, together with demonstrating satisfactory ability to express function when used to introduce a gene or antisense nucleic acid and the like, enables concentration to be adjusted easily, offers easy handling and has superior storage performance.A freeze-dried product of a complex containing a nucleic acid, oligonucleic acid or derivative thereof; a cationic polymer, or cationic lipid or aggregate containing the same; and, an anionic polymer; a method for preparing the freeze-dried product, comprising a step of forming a complex by mixing a nucleic acid, oligonucleic acid or derivative thereof; a cationic polymer, or cationic lipid or aggregate containing the same; and an anionic polymer, and a step of freeze-drying the complex; a preparation, reagent or kit containing the freeze-dried product for introducing a nucleic acid, oligonucleic acid or derivative thereof; and, a method for introducing a nucleic acid, oligonucleic acid or derivative thereof into cells that uses the freeze-dried product.

    摘要翻译： 提供了一种冷冻干燥产物，连同表现出表达功能的能力，当用于引入基因或反义核酸等时，使得浓度可以容易地调节，提供易于处理并且具有优异的储存性能。 含有核酸，寡核酸或其衍生物的复合物的冷冻干燥产物; 阳离子聚合物，或含有它们的阳离子脂质或聚集体; 和阴离子聚合物; 一种制备冷冻干燥产品的方法，包括通过混合核酸，低聚核酸或其衍生物形成络合物的步骤; 阳离子聚合物，或含有它们的阳离子脂质或聚集体; 和阴离子聚合物，以及冷冻干燥复合物的步骤。 包含用于引入核酸，低聚核酸或其衍生物的冷冻干燥产物的制剂，试剂或试剂盒; 以及将核酸，低聚核酸或其衍生物引入使用冷冻干燥产物的细胞中的方法。

    Material to form a hydrogel
    4.
    发明授权
    Material to form a hydrogel 有权

    公开(公告)号：US10716874B2

    公开(公告)日：2020-07-21

    申请号：US15632090

    申请日：2017-06-23

    申请人： Yoshiyuki Koyama

    发明人： Yoshiyuki Koyama ,  Tomoko Ito

    IPC分类号： A61L26/00 ,  A61L15/60 ,  A61L15/22 ,  A61L31/14 ,  A61L31/04 ,  C08L39/06

    摘要： A soft film, a sponge, or a sheet in the dried state is provided, which is capable of forming a hydrogel absorbing water or blood. The film is obtainable by preparing a film-state material in the dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone, and bringing the film-state material into contact with the other remaining solution, and then drying or freeze-drying it.

    Cephalosporin compounds
    5.
    发明授权
    Cephalosporin compounds 失效
    头孢菌素化合物

    公开(公告)号：US4393058A

    公开(公告)日：1983-07-12

    申请号：US188417

    申请日：1980-09-18

    申请人： Osamu Makabe ,  Yasushi Murai ,  Tuneo Okonogi ,  Masahiro Onodera ,  Yoshiyuki Koyama ,  Takashi Yoshida

    发明人： Osamu Makabe ,  Yasushi Murai ,  Tuneo Okonogi ,  Masahiro Onodera ,  Yoshiyuki Koyama ,  Takashi Yoshida

    IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07C45/71 ,  C07D213/80 ,  C07D213/82 ,  C07D213/85 ,  C07D501/36

    CPC分类号： C07D213/80 ,  C07C45/71 ,  C07D213/82 ,  C07D213/85

    摘要： Cephalosporin compounds, intermediate compounds therefor, and processes for preparation thereof are described; the compounds have the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 can each represent hydrogen, a hydroxyl group, a lower alkoxy group, or a substituted or unsubstituted phenylalkoxy group; R.sub.3 represents hydrogen or a lower alkyl group; R.sub.4 represents hydrogen or a hydroxyl group; and R.sub.5 represents ##STR2## wherein R.sub.6 is hydrogen, a lower alkyl group, an aminoalkyl group, an aminoaralkyl group, a --(CH.sub.2).sub.n --SO.sub.3 Na group, or a --(CH.sub.2).sub.n --COR.sub.9 group [wherein R.sub.9 is a hydroxyl group, an OM group (wherein M is an alkali metal), an alkoxy group, or an ##STR3## group, (wherein R.sub.10 and R.sub.11, which may be the same or different, can represent hydrogen or an alkyl group), and n is 0 or an integer of from 1 to 4]; R.sub.7 is hydrogen, a lower alkyl group, an amino group, or a substituted or unsubstituted aryl group; and R.sub.8 represents hydrogen or a lower alkyl group; or, a pharmaceutically acceptable salt thereof.

    摘要翻译： 描述头孢菌素化合物，其中间体化合物及其制备方法; 化合物具有式（I）其中R 1和R 2各自表示氢，羟基，低级烷氧基或取代或未取代的苯基烷氧基; R3表示氢或低级烷基; R4代表氢或羟基; 其中R6为氢，低级烷基，氨基烷基，氨基烷基， - （CH2）n-SO3Na基或 - （CH2）n-COR9基[ 其中R 9为羟基，OM基（其中M为碱金属），烷氧基或基团（其中R10和R11可以相同或不同，表示氢或烷基 组），n为0或1〜4的整数]。 R7是氢，低级烷基，氨基或取代或未取代的芳基; R8代表氢或低级烷基; 或其药学上可接受的盐。

    Material to form a hydrogel
    6.
    发明授权
    Material to form a hydrogel 有权

    公开(公告)号：US11045575B2

    公开(公告)日：2021-06-29

    申请号：US16898990

    申请日：2020-06-11

    申请人： Yoshiyuki Koyama

    发明人： Yoshiyuki Koyama ,  Tomoko Ito

    IPC分类号： A61L26/00 ,  A61L15/60 ,  A61L15/22 ,  A61L31/14 ,  A61L31/04 ,  C08L39/06

    摘要： A soft film, a sponge, or a sheet in the dried state is provided, which is capable of forming a hydrogel absorbing water or blood. The film is obtainable by preparing a film-state material in the dried state from either a solution of poly(acrylic acid) or a solution of polyvinylpyrrolidone, and bringing the film-state material into contact with the other remaining solution, and then drying or freeze-drying it.

    Polymer-drug conjugate and a method of producing it
    10.
    发明授权
    Polymer-drug conjugate and a method of producing it 失效
    聚合物 - 药物共轭物及其生产方法

    公开(公告)号：US5130126A

    公开(公告)日：1992-07-14

    申请号：US676384

    申请日：1991-03-28

    申请人： Yoshiyuki Koyama ,  Shuji Kojima ,  Tsuyoshi Miyazaki ,  Akinori Suginaka ,  Takeo Matsumoto ,  Yoshishige Murata

    发明人： Yoshiyuki Koyama ,  Shuji Kojima ,  Tsuyoshi Miyazaki ,  Akinori Suginaka ,  Takeo Matsumoto ,  Yoshishige Murata

    IPC分类号： A61K31/557 ,  A61K47/48

    CPC分类号： A61K47/48215 ,  A61K31/557 ,  Y10S514/925

    摘要： The present invention provides a polymer-combined drug having directional characteristics to digestive organs, wherein it comprises a medicine combined with a polymer which has an alkyleneoxy group as a repeating unit. The polymer-combined drug is produced by reacting a polyoxyalkylene glycol having one or more terminal functional groups and a medicine, if necessary in a solvent, and if necessary in the presence of a catalyst. It is able to administer the drug orally or by intravenous injection so as to maintain the concentration in blood stably for a long time, and to absorb or take in digestive organs such as the stomach and intestines directly.

    摘要翻译： 本发明提供了具有消化器官方向特性的聚合物组合药物，其中包含与具有亚烷基氧基作为重复单元的聚合物组合的药物。 通过使具有一个或多个末端官能团的聚氧亚烷基二醇和药物（如果需要在溶剂中）和必要时在催化剂存在下反应来制备聚合物组合药物。 能够口服给药或静脉注射，以保持血液中的浓度长时间稳定，并直接吸收或摄入消化器官如肠胃。