公开(公告)号：US20080063703A1

公开(公告)日：2008-03-13

申请号：US11579246

申请日：2007-08-17

申请人： Yossi Gross ,  Yoram Sela ,  Ziv Belsky ,  Rina Lev ,  Daniel Goldstein

发明人： Yossi Gross ,  Yoram Sela ,  Ziv Belsky ,  Rina Lev ,  Daniel Goldstein

IPC分类号： A61K9/48 ,  A61N1/30

CPC分类号： A61B1/041 ,  A61B1/00016 ,  A61B1/00156 ,  A61B5/0008 ,  A61B5/01 ,  A61B5/036 ,  A61B5/073 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4839 ,  A61B17/3203 ,  A61B18/02 ,  A61B18/14 ,  A61B18/20 ,  A61B34/70 ,  A61B34/72 ,  A61J3/07 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0097 ,  A61K9/4808 ,  A61M31/002 ,  A61N1/05 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/37205 ,  A61N1/3756 ,  G01K13/002

摘要： Apparatus (30) for drug administration is provided, including an ingestible capsule (32), which includes a drug (36), stored by the capsule (32), and an environmentally-sensitive mechanism (18), adapted to change a state thereof responsively to a disposition of the capsule (32) within a gastrointestinal (GI) tract (50) of a subject. The capsule (32) further includes first and second electrodes (16), and a control component (14), adapted to facilitate passage of the drug (36), in response to a change of state of the environmentally-sensitive mechanism (18), through an epithelial layer of the GI tract (50) by driving the first and second electrodes (16) to apply a series of pulses at a current of less than about 10 mA, at a frequency of between about 12 Hz and about 24 Hz, and with a pulse duration of between about 0.5 milliseconds and about 3 milliseconds. Other embodiments are also described.

摘要翻译： 提供了用于药物给药的装置（30），包括可吸收胶囊（32），其包括由胶囊（32）储存的药物（36）和适于改变其状态的环境敏感性机构（18） 响应于胶囊（32）在受试者的胃肠（GI）道（50）内的布置。 胶囊（32）还包括响应于环境敏感机构（18）的状态改变而适于促进药物（36）通过的第一和第二电极（16）和控制部件（14） 通过驱动第一和第二电极（16）通过GI道（50）的上皮层以约12Hz至约24Hz的频率施加小于约10mA的电流的一系列脉冲 并且脉冲持续时间在约0.5毫秒至约3毫秒之间。 还描述了其它实施例。

公开(公告)号：US20050058701A1

公开(公告)日：2005-03-17

申请号：US10901742

申请日：2004-07-29

申请人： Yossi Gross ,  Yoram Sela ,  Ziv Belsky ,  Rina Lev ,  Daniel Goldstein

发明人： Yossi Gross ,  Yoram Sela ,  Ziv Belsky ,  Rina Lev ,  Daniel Goldstein

IPC分类号： A61B1/05 ,  A61B5/00 ,  A61B5/03 ,  A61B5/07 ,  A61B17/32 ,  A61B18/02 ,  A61B18/14 ,  A61B18/20 ,  A61B19/00 ,  A61J3/07 ,  A61K9/00 ,  A61K9/22 ,  A61K9/48 ,  A61M31/00 ,  A61N1/05 ,  A61N1/30 ,  A61N1/32 ,  A61N1/36 ,  A61N1/372 ,  A61N1/375 ,  G01K13/00

CPC分类号： A61B1/041 ,  A61B1/00016 ,  A61B1/00156 ,  A61B5/0008 ,  A61B5/01 ,  A61B5/036 ,  A61B5/073 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4839 ,  A61B17/3203 ,  A61B18/02 ,  A61B18/14 ,  A61B18/20 ,  A61B34/70 ,  A61B34/72 ,  A61J3/07 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0097 ,  A61K9/4808 ,  A61M31/002 ,  A61N1/05 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/37205 ,  A61N1/3756 ,  G01K13/002

摘要： Apparatus for drug administration is provided, including an ingestible capsule, which includes a drug, stored by the capsule, and an environmentally-sensitive mechanism, adapted to change a state thereof responsively to a disposition of the capsule within a gastrointestinal (GI) tract of a subject. The capsule further includes first and second electrodes, and a control component, adapted to facilitate passage of the drug, in response to a change of state of the environmentally-sensitive mechanism, through an epithelial layer of the GI tract by driving the first and second electrodes to apply a series of pulses at a current of less than about 5 mA, at a frequency of between about 12 Hz and about 24 Hz, and with a pulse duration of between about 0.5 milliseconds and about 3 milliseconds.

摘要翻译： 提供了用于药物给药的装置，包括可摄入胶囊，其包括由胶囊储存的药物和环境敏感性机构，其适于改变其状态，其响应于胶囊在胃肠（GI） 课程。 胶囊还包括第一和第二电极以及控制部件，其适于响应于环境敏感性机构的状态改变而促进药物通过胃肠道的上皮层，通过驱动第一和第二 电极以小于约5mA的电流施加一系列脉冲，频率为约12Hz至约24Hz，脉冲持续时间为约0.5毫秒至约3毫秒。

公开(公告)号：US20060276844A1

公开(公告)日：2006-12-07

申请号：US11436439

申请日：2006-05-18

申请人： Ruth Alon ,  Rina Lev ,  Ziv Belsky

发明人： Ruth Alon ,  Rina Lev ,  Ziv Belsky

IPC分类号： A61N1/00

CPC分类号： A61N1/36007 ,  A61N1/05 ,  A61N1/205 ,  A61N1/37205 ,  A61N1/3756

摘要： Apparatus is provided including an ingestible device, which includes two or more electrodes, and a signal controller, configured to drive the electrodes to apply an electrical signal to an inner surface of a wall of a gastrointestinal (GI) tract of a subject, and to configure the signal to induce local endogenous release of nitric oxide (NO). Other embodiments are also described.

摘要翻译： 提供了包括包含两个或更多个电极的可摄取装置和信号控制器的装置，其被配置为驱动电极以将电信号施加到受试者的胃肠（GI）道的壁的内表面，并且 配置信号诱导局部内源性释放一氧化氮（NO）。 还描述了其它实施例。

公开(公告)号：US06993385B1

公开(公告)日：2006-01-31

申请号：US10111515

申请日：2000-10-24

申请人： Andre G. Routh ,  Edward Haluska ,  Nissim Darvish ,  David Prutchi ,  Ziv Belsky

发明人： Andre G. Routh ,  Edward Haluska ,  Nissim Darvish ,  David Prutchi ,  Ziv Belsky

IPC分类号： A61N1/18

CPC分类号： A61N1/3621 ,  A61N1/3627 ,  A61N1/39 ,  A61N1/3962

摘要： A cardiac contractility modulating (CCM) device includes an anti-arrhythmic therapy unit for detecting a cardiac arrhythmia in a heart of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating unit capable of delivering cardiac contractility modulating signals to the heart for modulating the contractility of a portion of the heart. The device may provide to the anti-arrhythmic therapy unit control signals associated with the delivery of the CCM signals to the heart. The control signals may be used to prevent interference of the CCM signals with the detecting of the cardiac arrhythmia. The device includes a power source. The device may be an implantable device or a non-implantable device. The device may also include a pacing unit.

摘要翻译： 心脏收缩力调节（CCM）装置包括抗心律失常治疗单元，用于基于处理与心脏感测到的心脏活动相关的电信号，以及用于向心脏递送抗心律失常疗法来检测患者心脏中的心律失常 。 该装置包括心脏收缩力调节单元，其能够向心脏输送心脏收缩调节信号，以调节一部分心脏的收缩性。 该装置可以向抗心律失常治疗单元提供与将CCM信号递送到心脏相关联的信号。 控制信号可以用于防止CCM信号与心律不齐的检测的干扰。 该装置包括电源。 该装置可以是可植入装置或非植入装置。 该装置还可以包括起搏单元。

公开(公告)号：US06370430B1

公开(公告)日：2002-04-09

申请号：US09572482

申请日：2000-05-16

申请人： Yuval Mika ,  Ziv Belsky

发明人： Yuval Mika ,  Ziv Belsky

IPC分类号： A61N136

CPC分类号： A61N1/3962 ,  A61B5/0452 ,  A61B5/7217 ,  A61B5/7264 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/368

摘要： A method and device for controlling the delivery of cardiac contractility modulating signals to the heart are disclosed. The method includes applying electrodes to a heart, sensing electrical activity in a first cardiac chamber and in at least a second cardiac chamber to detect events within a cardiac beat cycle and applying a cardiac contractility modulating signal to the heart at or about the first cardiac chamber in response to detecting an event within an alert window time interval. The applying of the cardiac contractility modulating signal is inhibited in response to detecting one or more inhibitory events occurring within specific time intervals defined within a current beat cycle. The method also includes the ignoring of events associated with expected electrical artifact signals if they occur within the duration of specified time intervals, to increase the therapy efficacy. The artifact signals may be associated with pacing of a cardiac chamber or with detected far field sensed electrical artifacts due to intrinsic chamber activation. The timing of the various time intervals and of the cardiac contractility signal may be computed on a beat by beat basis by utilizing a plurality of parameter sets stored in the device and the timing of events detected in each beat cycle. A method for determining and setting the parameter sets in a test session is disclosed.

摘要翻译： 公开了一种用于控制心脏收缩力调节信号传送到心脏的方法和装置。 该方法包括将电极施加到心脏，感测第一心室和第二心室中的电活动，以检测心搏周期内的事件，并将心脏收缩调节信号施加于第一心室或其周围的心脏 响应于检测到警报窗口时间间隔内的事件。 响应于检测在当前搏动周期内定义的特定时间间隔内发生的一个或多个抑制事件，抑制心肌收缩调节信号的应用。 该方法还包括忽略与预期的电假象信号相关联的事件，如果它们在指定时间间隔的持续时间内发生，以增加治疗功效。 神经信号可能与心室的起搏相关联，或与由于内腔活化而被检测到的远场感测到的电假象有关。 可以通过利用存储在设备中的多个参数集和在每个拍子周期中检测到的事件的定时，以搏动为基础计算各种时间间隔和心脏收缩信号的定时。 公开了一种在测试会话中确定和设置参数集的方法。

公开(公告)号：US20140039549A1

公开(公告)日：2014-02-06

申请号：US14113095

申请日：2012-04-23

申请人： Ziv Belsky ,  Gilad Hizkiyahu ,  Gil Bolotin

发明人： Ziv Belsky ,  Gilad Hizkiyahu ,  Gil Bolotin

IPC分类号： A61B17/12

CPC分类号： A61B17/12013 ,  A61B17/0057 ,  A61B17/0644 ,  A61B17/068 ,  A61B2017/00557 ,  A61B2017/00579 ,  A61B2017/00584 ,  A61B2017/00592 ,  A61B2017/00623 ,  A61B2017/00668 ,  A61B2017/00862 ,  A61B2017/00867 ,  A61B2017/0641

摘要： The present invention relates generally to a tissue closure device and in particular to a tissue closure device having a plurality of configurations providing for delivery and use in minimally invasive procedures. A tissue closure device (100) is provided from shape memory or super-elastic materials for closing a tissue site opening (50), the device comprising a plurality of tissue anchors (130) extending from a closed loop surface (110) wherein the plane of said tissue anchors is provided at an angle essentially perpendicular with respect to the plane of said closed loop surface; a. wherein said plurality of tissue anchors (130) comprise a proximal end (130p) and a distal end (130d); said distal end provided for anchoring said device onto tissue (50); and wherein said proximal end (130p) is fluid with and extends from said closed loop surface (110); and b. said closed loop surface (110) having a plurality of configurations including: a delivery configuration (1OOd), an open configuration (1000) and a closed configuration (100c) wherein said closed loop surface (110) may undergo a transformation between one of said plurality of configurations to another; said delivery configuration (1OOd) defining a low profile of said device (100) and adapted for delivery to a tissue site (50) through a small profile access point having a first diameter and wherein said closure device is utilized to close a tissue site having a second diameter such that said second diameter is larger than said first diameter.

摘要翻译： 本发明一般涉及一种组织闭合装置，特别涉及一种具有提供输送和使用于微创程序的多种构型的组织闭合装置。 从形状记忆体或超弹性材料提供组织闭合装置（100），用于封闭组织部位开口（50），所述装置包括从闭环表面（110）延伸的多个组织锚（130），其中平面 所述组织锚的角度以相对于所述闭环表面的平面基本垂直的角度设置; 一个。 其中所述多个组织锚固件（130）包括近端（130p）和远端（130d）; 所述远端用于将所述装置固定在组织（50）上; 并且其中所述近端（130p）与所述闭环表面（110）流体并且从所述闭环表面延伸。 和b。 所述闭环表面（110）具有多个构造，包括：输送构型（100d），开放构型（1000）和闭合构型（100c），其中所述闭环表面（110c）可经历所述闭环表面 多个配置到另一个; 所述输送构型（100d）限定所述装置（100）的低轮廓并且适于通过具有第一直径的小轮廓接入点输送到组织部位（50），并且其中所述闭合装置用于封闭具有 第二直径使得所述第二直径大于所述第一直径。

公开(公告)号：US06597952B1

公开(公告)日：2003-07-22

申请号：US09782347

申请日：2001-02-12

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61N1362

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for setting the parameters of an alert time window in an excitable tissue control device operative under a plurality of different cardiac conditions of a heart of a patient. The method includes providing said excitable tissue control device with a set of data including a plurality of sets of alert time window parameters. Each set of window parameters is uniquely associated with a different set of values of a plurality of cardiac condition defining parameters identifying one of the different cardiac conditions. Each set of window parameters includes at least a set of timing parameters usable for obtaining a beginning time point and an ending time point of the alert window. The sets of window parameters are obtained by processing data collected within a data collection session from a plurality of cardiac beats of the same patient under the different cardiac conditions.

摘要翻译： 一种用于在可患者组织控制装置中的警报时间窗口的参数设置方法，所述可激发组织控制装置在患者的心脏的多个不同心脏状态下工作。 该方法包括向所述可兴奋的组织控制装置提供包括多组警报时间窗参数的一组数据。 每套窗口参数与识别不同心脏状况之一的多个心脏病状定义参数的不同的值集合唯一地相关联。 每组窗口参数包括至少一组可用于获得警报窗口的开始时间点和结束时间点的定时参数。 窗口参数的集合通过在不同的心脏状况下处理来自同一患者的多个心跳的数据收集会话内收集的数据来获得。

公开(公告)号：US07953481B1

公开(公告)日：2011-05-31

申请号：US10111512

申请日：2000-10-25

申请人： Itzhak Shemer ,  Shay Policker ,  Ziv Belsky ,  Edward Haluska

发明人： Itzhak Shemer ,  Shay Policker ,  Ziv Belsky ,  Edward Haluska

IPC分类号： A61N1/365

CPC分类号： A61N1/39 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/3956

摘要： A cardiac contractility modulating (CCM) device (30) includes an anti-arrhythmic therapy unit (38) for detecting a cardiac arrhythmia in a heart (2) of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit (40) capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device (30) includes a power source (165). The device may be an implantable device or a non-implantable device. A method for delivering anti-arrhythmic therapy to a heart. The method includes applying one or more non-excitatory cardiac contractility modulating electrical signals to said heart.

摘要翻译： 心脏收缩力调节（CCM）装置（30）包括抗心律失常治疗单元（38），用于基于处理与心脏感测到的心脏活动相关的电信号来检测患者心脏（2）中的心律不齐，以及 用于向心脏递送抗心律失常药物。 该装置包括能够向心脏递送心脏收缩调节（CCM）信号以调节一部分心脏的收缩力的心脏收缩力调节（CCM）单元（40）。 设备（30）包括电源（165）。 该装置可以是可植入装置或非植入装置。 一种向心脏递送抗心律失常药物的方法。 该方法包括将一个或多个非兴奋性心脏收缩调节电信号应用于所述心脏。

公开(公告)号：US07647102B2

公开(公告)日：2010-01-12

申请号：US11283401

申请日：2005-11-18

申请人： Andre G. Routh ,  Edward Haluska ,  Nissim Darvish ,  David Prutchi ,  Ziv Belsky

发明人： Andre G. Routh ,  Edward Haluska ,  Nissim Darvish ,  David Prutchi ,  Ziv Belsky

IPC分类号： A61N1/00

CPC分类号： A61N1/3621 ,  A61N1/3627 ,  A61N1/39 ,  A61N1/3962

摘要： A cardiac contractility modulating (CCM) device (30) includes an anti-arrhythmic therapy unit (38) for detecting a cardiac arrhythmia in a heart (2) of a patient based on processing electrical signals related to cardiac activity sensed at the heart, and for delivering anti-arrhythmic therapy to the heart. The device includes a cardiac contractility modulating (CCM) unit (40) capable of delivering cardiac contractility modulating (CCM) signals to the heart for modulating the contractility of a portion of the heart. The device may provide to the anti-arrhythmic therapy unit control signals associated with the delivery of the CCM signals to the heart. The control signals may be used to prevent interference of the CCM signals with the detecting of the cardiac arrhythmia. The device (30) includes a power source. The device may be an implantable device or a non-implantable device. The device may also include a pacing unit.

摘要翻译： 心脏收缩力调节（CCM）装置（30）包括抗心律失常治疗单元（38），用于基于处理与心脏感测到的心脏活动相关的电信号来检测患者心脏（2）中的心律不齐，以及 用于向心脏递送抗心律失常药物。 该装置包括能够向心脏递送心脏收缩调节（CCM）信号以调节一部分心脏的收缩力的心脏收缩力调节（CCM）单元（40）。 该装置可以向抗心律失常治疗单元提供与将CCM信号递送到心脏相关联的信号。 控制信号可以用于防止CCM信号与心律不齐的检测的干扰。 设备（30）包括电源。 该装置可以是可植入装置或非植入装置。 该装置还可以包括起搏单元。

公开(公告)号：US06459928B2

公开(公告)日：2002-10-01

申请号：US09768968

申请日：2001-01-24

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A01B50402

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： Apparatus and method for obtaining from a patient's heart data useful for on-line setting of the parameters of a detection time window in an excitable tissue control device. The method includes applying electrodes to a first cardiac site and a second cardiac site of a patient and electrically connecting the electrodes to a data collecting device. The device is then operated under a plurality of different cardiac conditions to obtain a plurality of different histogram data sets. Each histogram data set represents a cumulative time distribution histogram of cardiac depolarization events detected at the second cardiac site in a plurality of cardiac beats. Each histogram data set is defined by a plurality of histogram parameters having values indicative of the cardiac conditions common to the plurality of cardiac beats used to obtain the histogram data set. The histogram parameters include a sensitivity level parameter representing the sensitivity level used for detecting the cardiac depolarization events of the plurality of cardiac beats at the second cardiac site. Another histogram parameter represents the range of values of the beat to beat time interval for the beats who's data is included in the histogram data set. Another histogram parameter has values indicating if the beats who's data is included in the histogram data set were acquired under conditions in which the delivery of non-excitatory ETC signals substantially affected or did not substantially affect the velocity of propagation of depolarization waves in the myocardium. Another histogram parameter, which may be used in devices having pacing capability has values indicating whether the beats who's data is included in the histogram data set are paced beats or non-paced beats. The histogram data sets are processed for computing a set of data usable for on-line setting of the parameters of a detection time window. This set of data may then be used for operating an implanted or external ETC device operatively connected to the electrodes.