公开(公告)号：US06430448B1

公开(公告)日：2002-08-06

申请号：US09707828

申请日：2000-11-07

申请人： Yougandh Chitre ,  Phong Doan

发明人： Yougandh Chitre ,  Phong Doan

IPC分类号： A61N106

CPC分类号： A61N1/056

摘要： An implantable stimulating electrode for directly contacting the endocardium of a human heart exhibits low polarization values of less than about 0.3 mV and is intended for use with an implantable lead having an electrical connector coupled to the proximal end of a conductor for releasable attachment to a stimulating pulse generator. The electrode is comprised of a metallic substrate having an initially exposed outer surface substantially covered with a first inner layer of titanium nitride and a second outer layer of platinum black. The first inner layer of titanium nitride has a thickness of less than about 15 microns and the second outer layer of platinum black overlying the layer of titanium nitride, similarly, has a thickness of less than about 15 microns. The invention includes a method of making the implantable stimulating electrode.

公开(公告)号：US06430447B1

公开(公告)日：2002-08-06

申请号：US09707706

申请日：2000-11-07

申请人： Yougandh Chitre ,  Phong Doan

发明人： Yougandh Chitre ,  Phong Doan

IPC分类号： A61N106

CPC分类号： A61N1/056

摘要： An implantable stimulating electrode for directly contacting the endocardium of a human heart exhibits low polarization values of less than about 0.3 mV and is intended for use with an implantable lead having an electrical connector coupled to the proximal end of a conductor for releasable attachment to a stimulating pulse generator. The electrode is comprised of a metallic substrate having an initially exposed outer surface substantially covered with a first inner layer of titanium nitride and a second outer layer of platinum black. The first inner layer of titanium nitride has a thickness of less than about 15 microns and the second outer layer of platinum black overlying the layer of titanium nitride, similarly, has a thickness of less than about 15 microns. The invention includes a method of making the implantable stimulating electrode.

摘要翻译： 用于直接接触人心内膜的可植入刺激电极显示小于约0.3mV的低偏振值，并且旨在用于具有耦合到导体的近端的电连接器的可植入导线，用于可释放地附接到刺激 脉冲发生器。 电极由具有初始暴露的外表面的金属基底构成，其基本上覆盖有第一内层氮化钛和第二外层铂黑。 氮化钛的第一内层具有小于约15微米的厚度，并且类似地覆盖在氮化钛层上的第二外层铂黑的厚度小于约15微米。 本发明包括制造可植入刺激电极的方法。

公开(公告)号：US06198973B1

公开(公告)日：2001-03-06

申请号：US09320405

申请日：1999-05-26

申请人： Phong Doan ,  Lisa Caffee ,  Yougandh Chitre

发明人： Phong Doan ,  Lisa Caffee ,  Yougandh Chitre

IPC分类号： A61N104

CPC分类号： A61N1/0568

摘要： An electrode assembly for a body implantable lead comprises a longitudinally extending dispenser housing having an internal cavity with opposed longitudinally extending openings for storing a drug to be dispensed. A tip electrode integral and axially aligned with the dispenser housing has a face adapted for positioning adjacent the desired body site, a transverse channel formed into and transversely across its face, and an orifice extending between the channel and the internal cavity for elution of the drug to the desired body site. A weld sleeve integral and axially aligned with the dispenser housing distant from the tip electrode has an outer peripheral surface for engageably receiving one end of an elongated electrical conductor, and a collar spaced from the dispenser housing. The electrical conductor is welded to the collar to obtain a welded connection for electrical continuity between the tip electrode and the electrical conductor. An insulative sheath of resilient material is fittingly received on the outer peripheral surface of the dispenser housing overlying the longitudinally extending openings and the welded connection between the electrical conductor and the weld sleeve. Insulative tubing is received on the coiled conductor includes a skirt member distant from the tip electrode and coaxial with the insulative tubing and biased radially into engagement with the outer peripheral surface of the insulative tubing. A plurality of fixation tines are integral with, and extend radially outwardly from, the insulative sheath at a plurality of circumferentially spaced locations.

摘要翻译： 用于身体可植入引线的电极组件包括纵向延伸的分配器壳体，其具有内部空腔，具有相对的纵向延伸的开口，用于储存待分配的药物。 与分配器壳体一体并且轴向对齐的尖端电极具有适于邻近所需体部位置定位的面，形成在其表面上并横向横过其表面的横向通道，以及在通道和内腔之间延伸以用于药物洗脱的孔 到所需的身体部位。 与远离尖端电极的分配器壳体一体并且轴向对齐的焊接套筒具有用于可接合地接纳细长电导体的一端的外周面和与分配器壳体间隔开的套环。 电导体焊接到套环以获得用于尖端电极和电导体之间的导电性的焊接连接。 弹性材料的绝缘护套适当地容纳在分配器壳体的外周表面上，覆盖纵向延伸的开口以及电导体和焊接套管之间的焊接连接。 绝缘管被接收在线圈导体上，包括远离尖端电极并与绝缘管同轴并且径向偏压地与绝缘管的外周表面接合的裙部构件。 在多个周向间隔开的位置处，多个固定齿与绝缘护套成一体并且从其径向向外延伸。

公开(公告)号：US5158547A

公开(公告)日：1992-10-27

申请号：US681955

申请日：1991-04-08

申请人： Phong Doan ,  William S. Nettecoven

发明人： Phong Doan ,  William S. Nettecoven

IPC分类号： A61M5/142

CPC分类号： A61M5/14276 ,  A61M2209/045 ,  A61M39/22

摘要： A technique for protecting an implantable drug administration device from damage caused by over filling. The protection is implemented using an automatic valve positioned between the puncturable sealing septum and the reservoir. This automatic valve is operated volumetrically by coupling the valve actuator to the diaphragm which separates the drug chamber from the fluid volume compensation chamber. When the diaphragm flexes to the maximum fill position, the valve actuator closes the automatic valve, thus prohibiting any further transfer to the reservoir.

摘要翻译： 一种用于保护可植入药物施用装置免受由过度填充造成的损害的技术。 使用位于可刺破的密封隔膜和储存器之间的自动阀来实现保护。 该自动阀通过将阀致动器连接到将药物室与流体容积补偿室分隔开的隔膜来体积运行。 当隔膜弯曲到最大填充位置时，阀门执行器关闭自动阀，从而禁止进一步转移到储存器。

公开(公告)号：US4650469A

公开(公告)日：1987-03-17

申请号：US769879

申请日：1985-08-27

申请人： Harvey F. Berg ,  Lyle Peterson ,  James E. Leslie ,  Phong Doan

发明人： Harvey F. Berg ,  Lyle Peterson ,  James E. Leslie ,  Phong Doan

IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M5/00

CPC分类号： A61M5/142 ,  A61M2005/14533 ,  A61M2205/12 ,  A61M2205/128

摘要： A system for delivering a drug to a patient according to the preferred embodiment of the present invention is shown as being of modular construction including a control module and a reservoir module. The reservoir module is removably secured to the control module by a removable hinge member at one end and a locking member at the other end. The reservoir module includes a pressure plate upon which a tube extending from a drug container bag to the patient is supported. The control module includes a pumping mechanism including a camshaft which reciprocates valves and an expulsor in the control module engaging and interacting with the tube located on the pressure plate for forcing the drug from the drug container bag to the patient. In its most preferred form, the pressure plate includes standoffs which abut with the pump chassis for insuring proper spacing maintenance between the pressure plate of the reservoir module and the control module. In another aspect of the present invention, an occlusion detector is provided in the system including a switch on the control module which also engages and interacts with the tube of the reservoir module. The occlusion detector interrupts operation of the pumping mechanism in the event of reduced pressure in the tube.

摘要翻译： 根据本发明的优选实施例的用于将药物递送到患者的系统被示出为包括控制模块和储存器模块的模块化结构。 储存器模块通过一端的可拆卸的铰链构件和另一端的锁定构件可移除地固定到控制模块。 储存器模块包括压力板，从药物容器袋延伸到患者的管被支撑在该压力板上。 控制模块包括泵送机构，其包括使阀门往复运动的凸轮轴和控制模块中的展开器，其与位于压力板上的管接合并相互作用，以迫使药物从药物容器袋向患者施加。 在其最优选的形式中，压板包括与泵底盘邻接的支座，用于确保储存器模块的压板和控制模块之间的适当的间隔保持。 在本发明的另一方面，在该系统中设置一个闭塞检测器，该闭塞检测器包括控制模块上的开关，该开关也与贮存器模块的管接合并相互作用。 堵塞检测器在管中的压力降低的情况下中断泵送机构的操作。

公开(公告)号：US20050251240A1

公开(公告)日：2005-11-10

申请号：US10842888

申请日：2004-05-10

申请人： Phong Doan

发明人： Phong Doan

IPC分类号： A61N1/05

CPC分类号： A61N1/0573 ,  A61N2001/0578

摘要： An implantable endocardial lead for use with a cardiac stimulation device includes an active fixation helix disposed at the distal end of the lead. The helix is constructed of flat wire having a non-circular cross section. The helix may be fixed or movable between a retracted position fully within the lead and an extended position advanced beyond the distal end of the lead.

摘要翻译： 用于心脏刺激装置的可植入心内膜包括设置在引线远端的活动固定螺旋。 螺旋线由具有非圆形横截面的扁平线构成。 螺旋可以在完全在引线内的缩回位置和超出引线远端的延伸位置之间固定或移动。