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公开(公告)号：US20110053873A1
公开(公告)日：2011-03-03
申请号：US12865713
申请日：2009-01-30
申请人： Young K. Chen , Eric Wang Co , Prasuna Guntupalli , John David Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
发明人： Young K. Chen , Eric Wang Co , Prasuna Guntupalli , John David Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
IPC分类号： C07D471/04 , A61K31/497 , A61K31/4985 , A61K31/519 , A61K31/5377 , C07H17/02 , A61K31/706 , A61P35/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P19/02 , A61P9/00
CPC分类号： C07D401/10 , C07D239/84 , C07D401/14 , C07D487/04
摘要： The invention relates to HSP90 inhibiting compounds consisting of the formula: (I) wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 本发明涉及由下式（I）组成的HSP90抑制化合物，其中变量如本文所定义。 本发明还涉及包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20120172321A1
公开(公告)日：2012-07-05
申请号：US13410045
申请日：2012-03-01
申请人： Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
发明人： Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
IPC分类号： A61K31/7064 , A61K31/5377 , C07H15/04 , A61K31/519 , C07D471/04 , C07H99/00
CPC分类号： C07D401/10 , C07D239/84 , C07D401/14 , C07D487/04
摘要： The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号：US20090305998A1
公开(公告)日：2009-12-10
申请号：US12363640
申请日：2009-01-30
申请人： Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
发明人： Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
IPC分类号： A61K31/7064 , C07D401/10 , A61K31/517 , C07D471/04 , A61K31/519 , A61K31/5377 , A61P35/00 , C07K14/47 , C07H7/06
CPC分类号： C07D401/10 , C07D239/84 , C07D401/14 , C07D487/04
摘要： The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 本发明涉及由下式组成的HSP90抑制化合物：其中变量如本文所定义。 本发明还涉及包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US08071766B2
公开(公告)日：2011-12-06
申请号：US12363640
申请日：2009-01-30
申请人： Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
发明人： Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
IPC分类号： C07D471/04 , C07D487/04 , A61K31/4375
CPC分类号： C07D401/10 , C07D239/84 , C07D401/14 , C07D487/04
摘要： The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 本发明涉及由下式组成的HSP90抑制化合物：其中变量如本文所定义。 本发明还涉及包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US20100069431A1
公开(公告)日：2010-03-18
申请号：US12065607
申请日：2006-09-01
申请人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
发明人： Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要： Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译： 提供化合物，药物组合物，试剂盒和方法用于含有选自式（I）的化合物的葡糖激酶，其中变量如本文所定义。
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公开(公告)号：US08952298B2
公开(公告)日：2015-02-10
申请号：US13376541
申请日：2010-06-11
申请人： Kim Charles Fietsam , Gregory K. Swanson , Daryl R. Monroe , Steven M. Shei , Daniel Marvin Henke , Robert J. Reese , Jeffrey A. Stafford
发明人： Kim Charles Fietsam , Gregory K. Swanson , Daryl R. Monroe , Steven M. Shei , Daniel Marvin Henke , Robert J. Reese , Jeffrey A. Stafford
CPC分类号： A47J37/044 , A21B1/22 , A47J37/045 , F27B9/063 , F27D11/02
摘要： A new electric broiler is disclosed. The broiler includes a housing having a cooking chamber, and a cooking surface in the housing. Upper and lower electrical heat sources are provided in the cooking chamber above and below the cooking surface. The lower heat source includes a removable heating module having an electric heating element and a quick connect/disconnect connector for quick electrical connection and disconnection of the electric heating element to and from a quick connect/disconnect connector on the housing. The broiler also includes a module holder on the housing for holding the removable heating module. The heating module is removable from the holder for quick replacement of the module.
摘要翻译： 公开了一种新的电烤肉机。 肉鸡包括具有烹饪室的壳体和壳体中的烹饪表面。 上部和下部电热源设置在烹饪表面上方和下方的烹饪室中。 下热源包括具有电加热元件和快速连接/断开连接器的可拆卸加热模块，用于将电加热元件快速连接和断开到外壳上的快速连接/断开连接器。 肉鸡还包括用于保持可移除加热模块的壳体上的模块支架。 加热模块可从支架上拆下，以便更换模块。
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公开(公告)号：US08278450B2
公开(公告)日：2012-10-02
申请号：US12103882
申请日：2008-04-16
申请人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Nicholas Scorah , Jeffrey A. Stafford , Michael B. Wallace , Hasanthi Wijesekera
发明人： Jason W. Brown , Qing Dong , Bheema R. Paraselli , Nicholas Scorah , Jeffrey A. Stafford , Michael B. Wallace , Hasanthi Wijesekera
IPC分类号： C07D471/00 , C07D209/88
CPC分类号： C07D471/14 , C07D241/18 , C07D401/12 , C07D471/04 , C07D487/04
摘要： Compounds are provided for use with kinases that comprise a compound selected from the group consisting of: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译： 提供化合物用于与包含选自以下的化合物的激酶一起使用：其中变量如本文所定义。 还提供了包含这些化合物的药物组合物，试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号：US08222411B2
公开(公告)日：2012-07-17
申请号：US12066769
申请日：2006-09-15
申请人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Paul R. Brodfuahrer , Bruce Elder , Paul Isbester , Richard S. Fornicola , Philip B. Kisanga , Bingidimi I. Mobele , Grant J. Palmer , Maxwell M. Reeve , Jonathon S. Salsbury , Luckner Ulysse , Sripathy Venkatraman
发明人： Jun Feng , Stephen L. Gwaltney , Jeffrey A. Stafford , Zhiyuan Zhang , Paul R. Brodfuahrer , Bruce Elder , Paul Isbester , Richard S. Fornicola , Philip B. Kisanga , Bingidimi I. Mobele , Grant J. Palmer , Maxwell M. Reeve , Jonathon S. Salsbury , Luckner Ulysse , Sripathy Venkatraman
IPC分类号： C07D239/02
CPC分类号： C07D239/553 , C07D239/545 , C07D401/04 , C07D401/14 , C07D403/12 , C07D409/14
摘要： Methods of making compounds of the formula (I) wherein the variables are as defined herein. Also, methods of making compounds that may be used to inhibit dipeptidyl peptidase.
摘要翻译： 制备式（I）化合物的方法，其中变量如本文所定义。 另外，制备可用于抑制二肽基肽酶的化合物的方法。
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公开(公告)号：US20120085746A1
公开(公告)日：2012-04-12
申请号：US13376541
申请日：2010-06-11
申请人： Kim Charles Fietsam , Gregory K. Swanson , Daryl R. Monroe , Steven M. Shei , Daniel Marvin Henke , Robert J. Reese , Jeffrey A. Stafford
发明人： Kim Charles Fietsam , Gregory K. Swanson , Daryl R. Monroe , Steven M. Shei , Daniel Marvin Henke , Robert J. Reese , Jeffrey A. Stafford
CPC分类号： A47J37/044 , A21B1/22 , A47J37/045 , F27B9/063 , F27D11/02
摘要： A new electric broiler is disclosed. The broiler includes a housing having a cooking chamber, and a cooking surface in the housing. Upper and lower electrical heat sources are provided in the cooking chamber above and below the cooking surface. The lower heat source includes a removable heating module having an electric heating element and a quick connect/disconnect connector for quick electrical connection and disconnection of the electric heating element to and from a quick connect/disconnect connector on the housing. The broiler also includes a module holder on the housing for holding the removable heating module. The heating module is removable from the holder for quick replacement of the module.
摘要翻译： 公开了一种新的电烤肉机。 肉鸡包括具有烹饪室的壳体和壳体中的烹饪表面。 上部和下部电热源设置在烹饪表面上方和下方的烹饪室中。 下热源包括具有电加热元件和快速连接/断开连接器的可拆卸加热模块，用于将电加热元件快速连接和断开到外壳上的快速连接/断开连接器。 肉鸡还包括用于保持可移除加热模块的壳体上的模块支架。 加热模块可从支架上拆下，以便更换模块。
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公开(公告)号：US08093382B2
公开(公告)日：2012-01-10
申请号：US12964410
申请日：2010-12-09
IPC分类号： C07D513/04
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a member selected from the group consisting of: wherein E is CH or N, Q is selected from the group consisting of CO, CS, SO, SO2, or C═NR4, and L, X, Z, R2 and R3 are as defined herein.
摘要翻译： 提供化合物，药物，试剂盒和方法用于DPP-IV和其它S9蛋白酶，其包含选自以下的成员：其中E是CH或N，Q选自CO，CS，SO ，SO 2或C≡NR4，并且L，X，Z，R 2和R 3如本文所定义。
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