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公开(公告)号:US08071766B2
公开(公告)日:2011-12-06
申请号:US12363640
申请日:2009-01-30
申请人: Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
发明人: Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
IPC分类号: C07D471/04 , C07D487/04 , A61K31/4375
CPC分类号: C07D401/10 , C07D239/84 , C07D401/14 , C07D487/04
摘要: The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 本发明涉及由下式组成的HSP90抑制化合物:其中变量如本文所定义。 本发明还涉及包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US20120172321A1
公开(公告)日:2012-07-05
申请号:US13410045
申请日:2012-03-01
申请人: Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
发明人: Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
IPC分类号: A61K31/7064 , A61K31/5377 , C07H15/04 , A61K31/519 , C07D471/04 , C07H99/00
CPC分类号: C07D401/10 , C07D239/84 , C07D401/14 , C07D487/04
摘要: The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
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公开(公告)号:US20090305998A1
公开(公告)日:2009-12-10
申请号:US12363640
申请日:2009-01-30
申请人: Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
发明人: Young K. Chen , Erick Co , Prasuna Guntupalli , John D. Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
IPC分类号: A61K31/7064 , C07D401/10 , A61K31/517 , C07D471/04 , A61K31/519 , A61K31/5377 , A61P35/00 , C07K14/47 , C07H7/06
CPC分类号: C07D401/10 , C07D239/84 , C07D401/14 , C07D487/04
摘要: The invention relates to HSP90 inhibiting compounds consisting of the formula: wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 本发明涉及由下式组成的HSP90抑制化合物:其中变量如本文所定义。 本发明还涉及包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US20110053873A1
公开(公告)日:2011-03-03
申请号:US12865713
申请日:2009-01-30
申请人: Young K. Chen , Eric Wang Co , Prasuna Guntupalli , John David Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
发明人: Young K. Chen , Eric Wang Co , Prasuna Guntupalli , John David Lawson , Wolfgang Reinhard Ludwig Notz , Jeffrey A. Stafford , Huong-Thu Ton-Nu
IPC分类号: C07D471/04 , A61K31/497 , A61K31/4985 , A61K31/519 , A61K31/5377 , C07H17/02 , A61K31/706 , A61P35/00 , A61P25/16 , A61P25/28 , A61P29/00 , A61P19/02 , A61P9/00
CPC分类号: C07D401/10 , C07D239/84 , C07D401/14 , C07D487/04
摘要: The invention relates to HSP90 inhibiting compounds consisting of the formula: (I) wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 本发明涉及由下式(I)组成的HSP90抑制化合物,其中变量如本文所定义。 本发明还涉及包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US08124617B2
公开(公告)日:2012-02-28
申请号:US12065607
申请日:2006-09-01
申请人: Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A Stafford , Beverly Wolgast
发明人: Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A Stafford , Beverly Wolgast
IPC分类号: A61K31/44 , C07D513/02 , C07D515/02
CPC分类号: A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于含有选自式(I)的化合物的葡糖激酶,其中变量如本文所定义。
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公开(公告)号:US20100069431A1
公开(公告)日:2010-03-18
申请号:US12065607
申请日:2006-09-01
申请人: Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
发明人: Hidehisa Iwata , Yasuhisa Kohara , Sheldon X. Cao , Prasuna Guntupalli , Stephen L. Gwaltney , David J. Hosfield , Yan Liu , Jeffrey A. Stafford , Beverly Throop
IPC分类号: A61K31/437 , C07D471/02
CPC分类号: A61K31/437 , A61K9/2018 , A61K9/4858 , C07D471/02 , C07D471/04 , C12N9/1205 , C12Y207/01001
摘要: Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of formula (I) wherein the variables are as defined herein.
摘要翻译: 提供化合物,药物组合物,试剂盒和方法用于含有选自式(I)的化合物的葡糖激酶,其中变量如本文所定义。
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公开(公告)号:US08173645B2
公开(公告)日:2012-05-08
申请号:US12052646
申请日:2008-03-20
申请人: Zacharia Cheruvallath , Jun Feng , Prasuna Guntupalli , Stephen L. Gwaltney , Joanne Miura , Mark Sabat , Mingnam Tang
发明人: Zacharia Cheruvallath , Jun Feng , Prasuna Guntupalli , Stephen L. Gwaltney , Joanne Miura , Mark Sabat , Mingnam Tang
IPC分类号: A61K31/496 , C07D417/12 , C07D417/14 , A61K31/541 , C07D513/04
CPC分类号: C07D417/12 , C07D405/14 , C07D417/14 , C07D513/04
摘要: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供了与包含下式的葡糖激酶一起使用的化合物:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US20070213349A1
公开(公告)日:2007-09-13
申请号:US11683955
申请日:2007-03-08
申请人: Zacharia Cheruvallath , Jun Feng , Prasuna Guntupalli , Stephen Gwaltney , Stephen Kaldor , Joanne Miura , Mark Sabat , Mingnam Tang , Beverly Wolgast
发明人: Zacharia Cheruvallath , Jun Feng , Prasuna Guntupalli , Stephen Gwaltney , Stephen Kaldor , Joanne Miura , Mark Sabat , Mingnam Tang , Beverly Wolgast
IPC分类号: A61K31/517 , A61K31/513 , C07D239/96 , C07D239/56
CPC分类号: C07D417/12 , C07D401/12
摘要: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供了与包含下式的葡糖激酶一起使用的化合物:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US08530499B2
公开(公告)日:2013-09-10
申请号:US13426365
申请日:2012-03-21
申请人: Zacharia Cheruvallath , Jun Feng , Prasuna Guntupalli , Stephen L. Gwaltney , Joanne Miura , Mark Sabat , Mingnam Tang , Haxia Wang
发明人: Zacharia Cheruvallath , Jun Feng , Prasuna Guntupalli , Stephen L. Gwaltney , Joanne Miura , Mark Sabat , Mingnam Tang , Haxia Wang
IPC分类号: A61K31/4433 , A61K31/4412 , C07D405/14 , C07D211/40
CPC分类号: C07D471/04 , C07D213/64 , C07D213/71 , C07D213/75 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/04 , C07D405/06 , C07D405/12 , C07D407/14 , C07D409/06 , C07D409/12 , C07D413/04 , C07D417/12 , C07D417/14 , C07D513/04
摘要: Compounds of the following formula are provided for use with glucokinase: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于葡萄糖激酶:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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公开(公告)号:US08034822B2
公开(公告)日:2011-10-11
申请号:US11683955
申请日:2007-03-08
申请人: Zacharia Cheruvallath , Jun Feng , Prasuna Guntupalli , Stephen L. Gwaltney , Stephen W. Kaldor , Joanne Miura , Mark Sabat , Mingnam Tang , Beverly Wolgast
发明人: Zacharia Cheruvallath , Jun Feng , Prasuna Guntupalli , Stephen L. Gwaltney , Stephen W. Kaldor , Joanne Miura , Mark Sabat , Mingnam Tang , Beverly Wolgast
IPC分类号: A61K31/517 , A01N43/54 , C07D239/72
CPC分类号: C07D417/12 , C07D401/12
摘要: Compounds are provided for use with glucokinase that comprise the formula: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供了与包含下式的葡糖激酶一起使用的化合物:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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