公开(公告)号：US08173171B2

公开(公告)日：2012-05-08

申请号：US12729376

申请日：2010-03-23

申请人： Yu-Chun Hung ,  Chi-Shu Wei ,  Lien-Hua Chiu ,  Wen-Yen Chiu ,  Chia-Jen Wen

发明人： Yu-Chun Hung ,  Chi-Shu Wei ,  Lien-Hua Chiu ,  Wen-Yen Chiu ,  Chia-Jen Wen

IPC分类号： A61K9/14

CPC分类号： A61K9/5026 ,  A61L15/28 ,  A61L15/60 ,  C08L5/08

摘要： Disclosed herein is a method for preparing a hydrogel microparticle composition. A dispersion including 1 part by weight of N-isopropyl acrylamide, about 0.1-0.5 part by weight of chitosan, about 0-0.05 part by weight of N,N′-methylene bisacrylamide, about 0.1-0.5 part by weight of glacial acetic acid, and about 20-40 parts by weight of water is prepared. About 0.01-0.3 part by weight of an anionic initiator is added into the dispersion and the dispersion is allowed to undergo a polymerization reaction at a temperature of about 10-100° C. for about 1 to 5 hours, thereby producing a plurality of hydrogel microparticles dispersed in the water to form the hydrogel microparticle composition.

摘要翻译： 本文公开了一种制备水凝胶微粒组合物的方法。 包含1重量份的N-异丙基丙烯酰胺，约0.1-0.5重量份的壳聚糖，约0-0.05重量份的N，N'-亚甲基双丙烯酰胺，约0.1-0.5重量份的冰醋酸 ，制备约20-40重量份的水。 将约0.01-0.3重量份的阴离子引发剂加入到分散体中，使分散体在约10-100℃的温度下进行聚合反应约1至5小时，从而产生多个水凝胶 微粒分散在水中以形成水凝胶微粒组合物。

公开(公告)号：US20100178345A1

公开(公告)日：2010-07-15

申请号：US12729376

申请日：2010-03-23

申请人： Yu-Chun Hung ,  Chi-Shu Wei ,  Lien-Hua Chiu ,  Wen-Yen Chiu ,  Chia-Jen Wen

发明人： Yu-Chun Hung ,  Chi-Shu Wei ,  Lien-Hua Chiu ,  Wen-Yen Chiu ,  Chia-Jen Wen

IPC分类号： A61K9/14 ,  A61K31/722 ,  A61P31/00

CPC分类号： A61K9/5026 ,  A61L15/28 ,  A61L15/60 ,  C08L5/08

摘要： Disclosed herein is a method for preparing a hydrogel microparticle composition. A dispersion including 1 part by weight of N-isopropyl acrylamide, about 0.1-0.5 part by weight of chitosan, about 0-0.05 part by weight of N,N′-methylene bisacrylamide, about 0.1-0.5 part by weight of glacial acetic acid, and about 20-40 parts by weight of water is prepared. About 0.01-0.3 part by weight of an anionic initiator is added into the dispersion and the dispersion is allowed to undergo a polymerization reaction at a temperature of about 10-100° C. for about 1 to 5 hours, thereby producing a plurality of hydrogel microparticles dispersed in the water to form the hydrogel microparticle composition.

摘要翻译： 本文公开了一种制备水凝胶微粒组合物的方法。 包含1重量份的N-异丙基丙烯酰胺，约0.1-0.5重量份的壳聚糖，约0-0.05重量份的N，N'-亚甲基双丙烯酰胺，约0.1-0.5重量份的冰醋酸 ，制备约20-40重量份的水。 将约0.01-0.3重量份的阴离子引发剂加入到分散体中，使分散体在约10-100℃的温度下进行聚合反应约1至5小时，从而产生多个水凝胶 微粒分散在水中以形成水凝胶微粒组合物。

公开(公告)号：US20050106256A1

公开(公告)日：2005-05-19

申请号：US10968283

申请日：2004-10-18

申请人： Yu-Chuen Hung ,  Chi-Shu Wei ,  Lien-Hua Chiu ,  Wen-Yen Chiu ,  Chia-Jen Wen

发明人： Yu-Chuen Hung ,  Chi-Shu Wei ,  Lien-Hua Chiu ,  Wen-Yen Chiu ,  Chia-Jen Wen

IPC分类号： A61K9/14 ,  A61L15/28 ,  A61L15/60

CPC分类号： A61L15/60 ,  A61L15/28

摘要： A composition of composite hydrogel microparticles containing polysaccharide or derivatives thereof and a method for preparing the same are disclosed. The method utilizes an ionic initiator to initiate a dispersion polymerization of a hydrogel monomer, and then performs a composite reaction with polysaccharide or derivatives thereof carrying opposite charges, so as to form composite hydrogel microparticles containing polysaccharide or derivatives thereof.

摘要翻译： 公开了含有多糖或其衍生物的复合水凝胶微粒的组合物及其制备方法。 该方法利用离子引发剂引发水凝胶单体的分散聚合，然后与具有相反电荷的多糖或其衍生物进行复合反应，以形成含有多糖或其衍生物的复合水凝胶微粒。