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公开(公告)号：US20070110784A1
公开(公告)日：2007-05-17
申请号：US10555455
申请日：2004-05-03
申请人： Yu-Ling Cheng , Michael May , John Semple , Hai-Hui Lin
发明人： Yu-Ling Cheng , Michael May , John Semple , Hai-Hui Lin
CPC分类号： A61F2/0059
摘要： The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.
摘要翻译： 本发明涉及热可逆凝胶如共聚物组合物作为生物填料或植入物的用途。 凝胶在体温下具有半固体形式，但是当冷却到低于阈值水平时，凝胶被液化，并且可以重新成形，重新调整尺寸，操作或从身体去除。 凝胶可以用作皮肤植入物，生物填充剂，关节或组织间隔物，用于皱纹填充或其它化妆品植入物，作为用于重建手术的软组织替代物，或作为生物结构内腔内的屏障，例如 作为血管。 植入物可用于通过提供例如子宫颈的可逆屏障或输精管腔的可逆阻塞来提供可逆的节育。
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公开(公告)号：US07160931B2
公开(公告)日：2007-01-09
申请号：US10428520
申请日：2003-05-02
申请人： Yu-Ling Cheng , Michael H. May , John L. Semple , Hai-Hui Lin
发明人： Yu-Ling Cheng , Michael H. May , John L. Semple , Hai-Hui Lin
CPC分类号： C08F283/06 , A61L24/06 , A61L27/16 , A61L27/50 , A61L27/52 , C08F293/00 , C08F297/00 , C08L51/003 , C08L51/08 , C08L53/00 , C08L53/005 , C08L33/26 , C08L2666/24 , C08L2666/02
摘要： The invention relates to the use of a thermal reversible gel, such as a copolymer composition, as a biological filler or implant. The gel has a semi-solid form at body temperature, but upon cooling to a temperature below a threshold level, the gel is liquefied and can be re-shaped, re-sized, manipulated or removed from the body. The gel may be used as a subcutaneous implant, a biological filler, joint or tissue spacer, for wrinkle filling or other cosmetic implants, as a soft-tissue replacement for reconstructive surgery, or as a barrier within the lumen of a biological structure, such as a blood vessel. The implant may be used to provide reversible birth control by providing, for example, a reversible barrier to the cervix or a reversible blockage of the lumen of the vas deferens.
摘要翻译： 本发明涉及热可逆凝胶如共聚物组合物作为生物填料或植入物的用途。 凝胶在体温下具有半固体形式，但是当冷却到低于阈值水平时，凝胶被液化，并且可以重新成形，重新调整尺寸，操作或从身体去除。 凝胶可以用作皮肤植入物，生物填充剂，关节或组织间隔物，用于皱纹填充或其它化妆品植入物，作为用于重建手术的软组织替代物，或作为生物结构内腔内的屏障，例如 作为血管。 植入物可用于通过提供例如子宫颈的可逆屏障或输精管腔的可逆阻塞来提供可逆的节育。
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公开(公告)号：US07193007B2
公开(公告)日：2007-03-20
申请号：US10221084
申请日：2001-03-15
申请人： Yu-Ling Cheng , Hai-Hui Lin
发明人： Yu-Ling Cheng , Hai-Hui Lin
IPC分类号： C08F290/04 , C08L53/00
CPC分类号： C08L53/00 , A61L27/16 , A61L27/52 , C08F293/00 , C08F297/00 , Y10S524/916
摘要： The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n>1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form in situ implants useful in slow-release formulations of biologically active molecules
摘要翻译： 本发明涉及在溶剂中包含共聚物的可胶凝共聚物组合物。 共聚物具有结构A（B）n，其中核（A）可溶于溶剂，臂（B）可根据环境条件在可溶性和不溶性之间转化，并且n> 1。 组合物通过形成B聚集体在环境条件下形成凝胶，其中B不溶。 公开了包含聚乙二醇（PEG）和聚环氧乙烷（PNIPAAm）在环境温度和水温条件下具有液态的嵌段共聚物和体温下的凝胶形式。 根据本发明的共聚物组合物可用于形成用于生物活性分子的缓释制剂的原位植入物
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公开(公告)号：US20050020719A1
公开(公告)日：2005-01-27
申请号：US10221084
申请日：2001-03-15
申请人： Yu-Ling Cheng , Hai-Hui Lin
发明人： Yu-Ling Cheng , Hai-Hui Lin
IPC分类号： A61L27/16 , A61L27/52 , C08F293/00 , C08F297/00 , C08L53/00 , C08K3/00 , A61F2/00 , C08F20/54 , C08L1/00
CPC分类号： C08L53/00 , A61L27/16 , A61L27/52 , C08F293/00 , C08F297/00 , Y10S524/916
摘要： The invention relates to a gelable copolymer composition comprising a copolymer in a solvent. The copolymer has the structure A(B)n, wherein the core (A) is soluble in the solvent, the arms (B) are convertible between soluble and insoluble in the solent depending on an environmental condition, and n>1. The composition forms a gel under environmental conditions in which B is insoluble, through formation of B aggregates. Block copolymers comprising polyethylene glycol (PEG) and poly(N-iso-propylacrylamide) (PNIPAAm) having a liquid form at ambient temperature under aqueous conditions and a gel form at body temperature are disclosed. Copolymer compositions according to the invention can be used to form in situ implants useful in slow-release formulations of biologically active molecules.
摘要翻译： 本发明涉及在溶剂中包含共聚物的可胶凝共聚物组合物。 共聚物具有结构A（B）n，其中核（A）可溶于溶剂，臂（B）可根据环境条件在可溶性和不溶性之间转化，并且n> 1。 组合物通过形成B聚集体在环境条件下形成凝胶，其中B不溶。 公开了包含聚乙二醇（PEG）和聚环氧乙烷（PNIPAAm）在环境温度和水温条件下具有液态的嵌段共聚物和体温下的凝胶形式。 根据本发明的共聚物组合物可用于形成用于生物活性分子的缓释制剂的原位植入物。
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5.发明授权
公开(公告)号：US4788062A
公开(公告)日：1988-11-29
申请号：US19162
申请日：1987-02-26
申请人： Robert M. Gale , David J. Enscore , Diane E. Nedberge , Melinda Nelson , Yu-Ling Cheng , Shari B. Libicki
发明人： Robert M. Gale , David J. Enscore , Diane E. Nedberge , Melinda Nelson , Yu-Ling Cheng , Shari B. Libicki
CPC分类号： A61K9/7053 , A61K31/565 , A61K31/57 , A61K47/14 , A61K47/26 , A61K9/0014 , A61K9/7076 , A61K9/7084
摘要： A transdermal delivery system for the administering of progesterone and an estradiol ester alone or in combination utilizing a polymer matrix having the drug(s) along with a permeation enhancer dispersed throughout.
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公开(公告)号：US5626877A
公开(公告)日：1997-05-06
申请号：US193997
申请日：1994-02-09
申请人： Brian G. Amsden , Yu-Ling Cheng
发明人： Brian G. Amsden , Yu-Ling Cheng
CPC分类号： A61K38/47 , A61K38/1808 , A61K9/0004 , A61K9/2009 , A61K9/2027
摘要： Described herein is a drug delivery system useful to deliver drugs at low dosage levels to patients in a sustained fashion and at a controlled rate. The system comprises a wettable polymeric matrix in which is dispersed a multiplicity of particles containing a substantially homogeneous blend of osmotically active excipient and not more than about 10% by weight of drug. The system is particularly well suited for delivery of therapeutic macromolecules such as protein drugs. Delivery of epidermal growth factor is exemplified.
摘要翻译： 本文描述了一种药物递送系统，其用于以持续的方式和以受控的速率向患者递送低剂量水平的药物。 该系统包括可湿性聚合物基质，其中分散有多个颗粒，其含有基本均匀的渗透活性赋形剂混合物和不超过约10重量％的药物。 该系统特别适用于递送治疗性大分子如蛋白质药物。 例举表皮生长因子的递送。
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公开(公告)号：US4746515A
公开(公告)日：1988-05-24
申请号：US19470
申请日：1987-02-26
申请人： Yu-Ling Cheng , Diane E. Nedberge , Edna Sugihara
发明人： Yu-Ling Cheng , Diane E. Nedberge , Edna Sugihara
CPC分类号： A61K9/7084 , A61K47/14 , A61K9/0014 , Y10S514/946
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with glycerol monolaurate. Preferred embodiments of therapeutic systems for delivering drug and glycerol monolaurate employ matrix containing drug at a concentration above saturation.
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公开(公告)号：US4940586A
公开(公告)日：1990-07-10
申请号：US257487
申请日：1988-10-13
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7069 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
摘要翻译： 描述了通过完整皮肤增强透皮递送药物的透皮通量的方法，其中药物与蔗糖单月桂酸酯或主要是蔗糖单月桂酸酯的椰子脂肪酸的蔗糖酯的混合物同时递送。 用于递送药物和蔗糖酯的治疗系统的优选实施方案使用含有高于饱和浓度的药物的基质。
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公开(公告)号：US4900555A
公开(公告)日：1990-02-13
申请号：US257481
申请日：1988-10-13
CPC分类号： A61K9/7053 , A61K47/26 , A61K9/7069 , A61K9/7084
摘要： A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominatly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.
摘要翻译： 描述了通过完整皮肤增强透皮递送药物的经皮通量的方法，其中药物与蔗糖单月桂酸酯或主要是蔗糖单月桂酸酯的椰子脂肪酸的蔗糖酯的混合物同时递送。 用于递送药物和蔗糖酯的治疗系统的优选实施方案使用含有高于饱和浓度的药物的基质。
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公开(公告)号：US20180092371A1
公开(公告)日：2018-04-05
申请号：US15723992
申请日：2017-10-03
摘要： A pasteurization device comprising an insulated heating tub, a metal grid heat sink, 69° C. melt-point paraffin wax, wherein the metal grid heat sink and the paraffin wax are combined inside the insulated heating tub; a temperature sensor connected to a microprocessor controlled device, suitable to measure temperature and to generate an alarm, a top plate, and a material suitable to cover the wax; wherein the top plate comprises a plurality of openings corresponding to an opening in the metal grid heat sink of suitable size to accept a baby bottle; wherein the insulated heating tub can be heated to at least 73° C. and wherein the microprocessor controlled device provides an audible tone upon the temperature sensor reading 73° C. for at least 30 seconds.
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