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公开(公告)号：US08496930B2
公开(公告)日：2013-07-30
申请号：US10574016
申请日：2004-10-01
IPC分类号： A61K39/395
CPC分类号： A61K9/0019 , A61K39/39591 , A61K47/12 , A61K47/183 , C07K16/18 , C07K16/2866 , C07K2317/24 , C07K2317/76
摘要： The present invention provides a method of suppressing the formation of a soluble association of an antibody in a solution; a method of suppressing the formation of a chemically degraded product of an antibody in a solution; and a method of stabilizing an antibody in a solution. The present invention also provides a solution-type antibody preparation in which the formation of a soluble association is suppressed; a solution-type antibody preparation in which the formation of a chemically degraded product is suppressed; a solution-type antibody preparation in which the formation of a soluble association, the formation of a chemically degraded product and the formation of an insoluble aggregate are suppressed; an agent for suppressing the formation of a soluble association of an antibody; an agent for suppressing the formation of a chemically degraded product of an antibody; and a stabilizing agent for an antibody.
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2.发明申请Method of stabilizing antibody and stabilized solution-type antibody preparation 有权稳定抗体和稳定溶液型抗体制剂的方法公开(公告)号：US20070020255A1
公开(公告)日：2007-01-25
申请号：US10574016
申请日：2004-10-01
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： A61K9/0019 , A61K39/39591 , A61K47/12 , A61K47/183 , C07K16/18 , C07K16/2866 , C07K2317/24 , C07K2317/76
摘要： The present invention provides a method of suppressing the formation of a soluble association of an antibody in a solution; a method of suppressing the formation of a chemically degraded product of an antibody in a solution; and a method of stabilizing an antibody in a solution. The present invention also provides a solution-type antibody preparation in which the formation of a soluble association is suppressed; a solution-type antibody preparation in which the formation of a chemically degraded product is suppressed; a solution-type antibody preparation in which the formation of a soluble association, the formation of a chemically degraded product and the formation of an insoluble aggregate are suppressed; an agent for suppressing the formation of a soluble association of an antibody; an agent for suppressing the formation of a chemically degraded product of an antibody; and a stabilizing agent for an antibody.
摘要翻译： 本发明提供抑制抗体在溶液中的可溶性结合形成的方法; 抑制溶液中抗体的化学降解产物的形成的方法; 以及在溶液中稳定抗体的方法。 本发明还提供抑制可溶性缔合的形成的溶液型抗体制剂; 抑制化学降解产物的形成的溶液型抗体制剂; 抑制了可溶性缔合物的形成，化学降解产物的形成和不溶性聚集体的形成的溶液型抗体制剂; 用于抑制抗体的可溶性缔合的形成的试剂; 用于抑制抗体的化学降解产物形成的试剂; 和抗体的稳定剂。
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