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    Producing optically active amino compounds
    1.
    发明授权
    Producing optically active amino compounds 有权
    生产光学活性氨基化合物

    公开(公告)号：US07169592B2

    公开(公告)日：2007-01-30

    申请号：US10112706

    申请日：2002-04-02

    申请人： Yukio Yamada ,  Akira Iwasaki ,  Noriyuki Kizaki ,  Keiji Matsumoto ,  Yasuhiro Ikenaka ,  Masahiro Ogura ,  Junzo Hasegawa

    发明人： Yukio Yamada ,  Akira Iwasaki ,  Noriyuki Kizaki ,  Keiji Matsumoto ,  Yasuhiro Ikenaka ,  Masahiro Ogura ,  Junzo Hasegawa

    IPC分类号： C12N9/10 ,  C12N1/21 ,  C12N15/54 ,  C12N15/63 ,  C12N15/82 ,  C12N15/85 ,  C07H21/04

    CPC分类号： C12P13/001 ,  C12N9/1096

    摘要： To provide a method for preparing optically active compounds, which mainly contain (R)-amino compounds, by microbial enzymes efficiently and inexpensively; a polypeptide having stereoselective transaminase activity which can be suitably used for the above preparation method; and a DNA encoding the polypeptide. A method for preparing an optically active amino compound, characterized in stereoselectively transaminating by acting a transaminase on an amino group acceptor, a ketone compound in the presence of an amino group donor, a primary amine; a DNA comprising a nucleotide sequence encoding a polypeptide having stereoselective transaminase activity; and a polypeptide having stereoselective transaminase activity obtainable from a culture of a microorganism belonging to the genus Arthrobacter.

    摘要翻译： 提供通过微生物酶有效且廉价地制备主要含有（R） - 氨基化合物的光学活性化合物的方法; 具有立体选择性转氨酶活性的多肽，可适用于上述制备方法; 和编码该多肽的DNA。 一种制备光学活性氨基化合物的方法，其特征在于通过在氨基受体上起转氨酶的作用，在氨基供体存在下的酮化合物，伯胺，立体选择性转氨酶; 包含编码具有立体选择性转氨酶活性的多肽的核苷酸序列的DNA; 和具有立体选择性转氨酶活性的多肽，其可从属于节杆菌属的微生物的培养物获得。

    Process for producing optically active amino compounds
    2.
    发明授权
    Process for producing optically active amino compounds 失效
    光学活性氨基化合物的制造方法

    公开(公告)号：US06221638B1

    公开(公告)日：2001-04-24

    申请号：US09064750

    申请日：1998-04-23

    申请人： Yukio Yamada ,  Akira Iwasaki ,  Noriyuki Kizaki ,  Yasuhiro Ikenaka ,  Masahiro Ogura ,  Junzo Hasegawa

    发明人： Yukio Yamada ,  Akira Iwasaki ,  Noriyuki Kizaki ,  Yasuhiro Ikenaka ,  Masahiro Ogura ,  Junzo Hasegawa

    IPC分类号： C12P1300

    CPC分类号： C12P13/001 ,  C12N9/1096 ,  C12P13/005 ,  C12P13/008 ,  C12P13/04 ,  C12P41/006 ,  Y10S435/83

    摘要： The method for preparing an optically active (R)-amino compound characterized by the method comprising stereoselectively carrying out amino group transfer by action of an (R)-form-specific transaminase in the co-presence of a ketone compound (amino acceptor), and an amino compound (amino donor) of a racemic form or an (R)-form, to give an optically active (R)-amino compound. According to the present invention, it is made possible to easily prepare at a high yield the optically active (R)-amino compounds and the like having an aryl group and the like at their 1-position, which have been conventionally difficult to prepare.

    摘要翻译： 制备光学活性（R） - 氨基化合物的方法，其特征在于在酮化合物（氨基受体）的共存下通过（R） - 形式 - 特异性转氨酶的作用立体选择性地进行氨基转移的方法， 和外消旋形式的氨基化合物（氨基供体）或（R） - 形式，得到光学活性（R） - 氨基化合物。 根据本发明，可以容易地容易地制备其1-位上具有芳基等的光学活性（R） - 氨基化合物等，其通常难以制备。

    (R)-transaminase from arthrobacter
    3.
    发明授权
    (R)-transaminase from arthrobacter 失效
    （R） - 转氨酶

    公开(公告)号：US06344351B2

    公开(公告)日：2002-02-05

    申请号：US09794359

    申请日：2001-02-28

    申请人： Yukio Yamada ,  Akira Iwasaki ,  Noriyuki Kizaki ,  Yasuhiro Ikenaka ,  Masahiro Ogura ,  Junzo Hasegawa

    发明人： Yukio Yamada ,  Akira Iwasaki ,  Noriyuki Kizaki ,  Yasuhiro Ikenaka ,  Masahiro Ogura ,  Junzo Hasegawa

    IPC分类号： C12N910

    CPC分类号： C12P13/001 ,  C12N9/1096 ,  C12P13/005 ,  C12P13/008 ,  C12P13/04 ,  C12P41/006 ,  Y10S435/83

    摘要： The method for preparing an optically active (R)-amino compound characterized by the method comprising stereoselectively carrying out amino group transfer by action of an (R)-form-specific transaminase in the co-presence of a ketone compound (amino acceptor), and an amino compound (amino donor) of a racemic form or an (R)-form, to give an optically active (R)-amino compound. According to the present invention, it is made possible to easily prepare at a high yield the optically active (R)-amino compounds and the like having an aryl group and the like at their 1-position, which have been conventionally difficult to prepare.

    摘要翻译： 制备光学活性（R） - 氨基化合物的方法，其特征在于在酮化合物（氨基受体）的共存下通过（R） - 形式 - 特异性转氨酶的作用立体选择性地进行氨基转移的方法， 和外消旋形式的氨基化合物（氨基供体）或（R） - 形式，得到光学活性（R） - 氨基化合物。 根据本发明，可以容易地容易地制备其1-位上具有芳基等的光学活性（R） - 氨基化合物等，其通常难以制备。

    Manufacturing method of optically-active 1,2-diols
    4.
    发明授权
    Manufacturing method of optically-active 1,2-diols 失效
    光学活性1,2-二醇的制备方法

    公开(公告)号：US4981796A

    公开(公告)日：1991-01-01

    申请号：US275200

    申请日：1988-11-23

    申请人： Masahiro Ogura ,  Tadayoshi Shiraishi ,  Hideyuki Takahashi ,  Junzo Hasegawa

    发明人： Masahiro Ogura ,  Tadayoshi Shiraishi ,  Hideyuki Takahashi ,  Junzo Hasegawa

    IPC分类号： C12P7/18 ,  C12P41/00

    CPC分类号： C12P7/18 ,  C12P41/00 ,  Y10S435/911 ,  Y10S435/921 ,  Y10S435/938

    摘要： A process of manufacturing optically active (S)-1,2-diols, wherein (R)-1,2-diols represented by the general formula [I] ##STR1## (where: R represents a substituted or unsubstituted alkyl group, alkenyl group, aryl group or aralkyl group) or a mixture of diols of the general formula [I] and (S)-1,2-diols represented by the general formula [II] ##STR2## (Where: R represents the same as above) having an opposite configuration to the general formula [I] is subjected to the action of a microorganism capable of selectively metabolizing the diols of the general formula [I], or capable of converting the diols of the general formula [I] into the diols of the general formula [II], or having the both capabilities, and the formed and accumulated (S)-1,2-diols of the general formula [II] is collected. According to the present invention, optically active (S)-1,2-diols can be produced commercially and advantageously.

    Positioning apparatus, exposure apparatus and method of manufacturing device
    8.
    发明授权
    Positioning apparatus, exposure apparatus and method of manufacturing device 有权
    定位装置，曝光装置及其制造方法

    公开(公告)号：US09057968B2

    公开(公告)日：2015-06-16

    申请号：US13551696

    申请日：2012-07-18

    申请人： Masahiro Ogura ,  Noriyasu Hasegawa ,  Yasuyuki Tamura

    发明人： Masahiro Ogura ,  Noriyasu Hasegawa ,  Yasuyuki Tamura

    IPC分类号： G03B27/58 ,  G03B27/42 ,  G03F7/20

    CPC分类号： G03F7/70758 ,  G03F7/70858

    摘要： A positioning apparatus for a moving object includes: a driving unit including a stator and a movable element connected to the moving object via a connecting member; a chassis which includes an opening which allows movement of the connecting member upon driving of the movable element, and an exhaust outlet which includes end exhaust outlets arranged at first and second ends of the driving range of the movable element; an exhaust unit which exhausts a gas in the chassis; and a controller which controls the exhaust unit so that an amount of exhaust from the end exhaust outlet arranged at the first end becomes larger when the movable element is driven toward the first end on a side of the first end of the driving range than when the movable element is positioned at the center of the driving range.

    摘要翻译： 一种用于移动物体的定位装置包括：驱动单元，其包括定子和经由连接构件连接到移动物体的可动元件; 底架，其包括允许连接构件在可移动元件驱动时运动的开口;以及排气口，其包括布置在可移动元件的驱动范围的第一和第二端处的末端排气口; 排气装置，其排出底盘中的气体; 以及控制器，其控制所述排气单元，使得当所述可移动元件在所述驱动范围的所述第一端的一侧的所述第一端被驱动时，排列在所述第一端处的所述末端排气口的排气量比所述第一端 可移动元件位于驱动范围的中心。

    POSITIONING APPARATUS, EXPOSURE APPARATUS AND METHOD OF MANUFACTURING DEVICE
    9.
    发明申请
    POSITIONING APPARATUS, EXPOSURE APPARATUS AND METHOD OF MANUFACTURING DEVICE 有权
    定位装置，曝光装置和制造装置的方法

    公开(公告)号：US20130045448A1

    公开(公告)日：2013-02-21

    申请号：US13551696

    申请日：2012-07-18

    申请人： Masahiro Ogura ,  Noriyasu Hasegawa ,  Yasuyuki Tamura

    发明人： Masahiro Ogura ,  Noriyasu Hasegawa ,  Yasuyuki Tamura

    IPC分类号： B23Q1/64 ,  G03F7/20 ,  G03B27/58

    CPC分类号： G03F7/70758 ,  G03F7/70858

    摘要： A positioning apparatus for a moving object includes: a driving unit including a stator and a movable element connected to the moving object via a connecting member; a chassis which includes an opening which allows movement of the connecting member upon driving of the movable element, and an exhaust outlet which includes end exhaust outlets arranged at first and second ends of the driving range of the movable element; an exhaust unit which exhausts a gas in the chassis; and a controller which controls the exhaust unit so that an amount of exhaust from the end exhaust outlet arranged at the first end becomes larger when the movable element is driven toward the first end on a side of the first end of the driving range than when the movable element is positioned at the center of the driving range.

    摘要翻译： 一种用于移动物体的定位装置包括：驱动单元，其包括定子和经由连接构件连接到移动物体的可动元件; 底架，其包括允许连接构件在可移动元件驱动时运动的开口;以及排气口，其包括布置在可移动元件的驱动范围的第一和第二端处的末端排气口; 排气装置，其排出底盘中的气体; 以及控制器，其控制所述排气单元，使得当所述可移动元件在所述驱动范围的所述第一端的一侧的所述第一端被驱动时，排列在所述第一端处的所述末端排气口的排气量比所述第一端 可移动元件位于驱动范围的中心。