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公开(公告)号:US08415376B2
公开(公告)日:2013-04-09
申请号:US12995431
申请日:2009-05-29
申请人: Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
发明人: Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
IPC分类号: A61K31/47 , C07D401/02 , C07D401/14
CPC分类号: C07D401/04 , C07D401/14 , C07D471/04
摘要: The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物,其中Q,X 1,X 2,R 1和Z如本文所定义。
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公开(公告)号:US20110092504A1
公开(公告)日:2011-04-21
申请号:US12995431
申请日:2009-05-29
申请人: Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
发明人: Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
IPC分类号: A61K31/5377 , C07D413/14 , C07D401/10 , C07D215/233 , A61K31/4709 , A61K31/47 , A61K31/498 , A61P35/00
CPC分类号: C07D401/04 , C07D401/14 , C07D471/04
摘要: The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物,其中Q,X 1,X 2,R 1和Z如本文所定义。
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公开(公告)号:US20100273764A1
公开(公告)日:2010-10-28
申请号:US12768602
申请日:2010-04-27
申请人: Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang
发明人: Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang
IPC分类号: A61K31/53 , C07D473/00 , A61K31/52 , C07D401/14 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/541 , C07D471/04 , C07D401/12 , C07D513/04 , A61P35/00 , A61P35/02
CPC分类号: C07D473/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译: 本发明涉及式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物,其中变量如本文所定义。
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公开(公告)号:US20120071474A1
公开(公告)日:2012-03-22
申请号:US13257582
申请日:2010-03-19
申请人: Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
发明人: Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
IPC分类号: A61K31/4355 , C07D487/04 , A61K31/5025 , A61P35/02 , A61K31/5377 , A61K31/519 , C07D471/06 , A61P35/00
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of Formula I, II or III or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译: 本发明涉及式I,II或III化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物,其中变量如本文所定义。
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公开(公告)号:US08729074B2
公开(公告)日:2014-05-20
申请号:US13257582
申请日:2010-03-19
申请人: Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
发明人: Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
IPC分类号: A61K31/535
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of Formula I, II or III or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译: 本发明涉及式I,II或III的化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物,其中变量如本文所定义。
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公开(公告)号:US07928140B2
公开(公告)日:2011-04-19
申请号:US12221416
申请日:2008-08-01
申请人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
发明人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
IPC分类号: A61K31/38
CPC分类号: C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04
摘要: The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译: 本发明包括能够调节PI3激酶活性的新一类化合物,因此可用于治疗PI3激酶介导的疾病,包括黑素瘤,癌和其它癌症相关病症。 所述化合物具有通式I,其中A1,A2,A3,A4,X,R1和R2各自在本文中定义。 本发明还包括药物组合物,治疗PI3激酶介导的疾病的方法,以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号:US20090054405A1
公开(公告)日:2009-02-26
申请号:US12221416
申请日:2008-08-01
申请人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
发明人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
IPC分类号: A61K31/55 , C07D401/14 , C07D401/10 , C07D413/14 , A61P35/00 , A61K31/435 , A61K31/5377 , A61K31/497
CPC分类号: C07D277/82 , C07D413/04 , C07D417/04 , C07D417/14 , C07D513/04
摘要: The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
摘要翻译: 本发明包括能够调节PI3激酶活性的新一类化合物,因此可用于治疗PI3激酶介导的疾病,包括黑素瘤,癌和其它癌症相关病症。 所述化合物具有通式I,其中A1,A2,A3,A4,X,R1和R2各自在本文中定义。 本发明还包括药物组合物,治疗PI3激酶介导的疾病的方法,以及可用于制备本发明化合物的中间体和方法。
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公开(公告)号:US08524900B2
公开(公告)日:2013-09-03
申请号:US13309488
申请日:2011-12-01
申请人: Brian K. Albrecht , David Bauer , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
发明人: Brian K. Albrecht , David Bauer , Christiane M. Bode , Shon Booker , Alessandro Boezio , Deborah Choquette , Derin D'Amico , Jean-Christophe Harmange , Satoko Hirai , Richard T. Lewis , Longbin Liu , Julia Lohman , Mark H. Norman , Michele Potashman , Aaron C. Siegmund , Stephanie K. Springer , Markian Stec , Ning Xi , Kevin Yang
IPC分类号: C07D487/04 , C07D403/12 , C07D403/14 , C07D401/12 , C07D401/14 , C07D413/14 , A61K31/5025 , A61K31/4353 , A61K31/4523 , A61P35/00
CPC分类号: A61K31/538 , A61K31/437 , A61K31/497 , A61K31/5025 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K45/06 , C07D403/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D493/04 , C07D495/04 , C07D498/04 , C07D519/00
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号:US20110118252A1
公开(公告)日:2011-05-19
申请号:US12945575
申请日:2010-11-12
申请人: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号: A61K31/4709 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/12 , A61K31/497 , A61K31/5377 , A61K31/506 , A61K31/496 , A61K31/501 , A61P35/00
CPC分类号: C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号:US20080312232A1
公开(公告)日:2008-12-18
申请号:US11412302
申请日:2006-04-26
申请人: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
发明人: Tae-Seong Kim , David Bauer , Steven Bellon , Alessandro Boezio , Shon Booker , Deborah Choquette , Derin C. D'Amico , Noel D'Angelo , Celia Dominguez , Ingrid M. Fellows , Julie Germain , Russell Graceffa , Jean-Christophe Harmange , Satoko Hirai , Daniel La , Matthew Lee , Longbin Liu , Mark H. Norman , Michele Potashman , Philip Roveto , Aaron C. Siegmund , Ning Xi , Kevin Yang
IPC分类号: A61K31/5377 , C07D413/12 , C07D401/14 , A61K31/4709 , C07D403/12 , A61K31/506 , A61K31/501 , C07D401/12 , A61K31/496
CPC分类号: C07D413/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D495/04
摘要: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物,类似物,前药和药学上可接受的盐,用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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