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公开(公告)号:US08415376B2
公开(公告)日:2013-04-09
申请号:US12995431
申请日:2009-05-29
申请人: Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
发明人: Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
IPC分类号: A61K31/47 , C07D401/02 , C07D401/14
CPC分类号: C07D401/04 , C07D401/14 , C07D471/04
摘要: The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物,其中Q,X 1,X 2,R 1和Z如本文所定义。
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公开(公告)号:US20110092504A1
公开(公告)日:2011-04-21
申请号:US12995431
申请日:2009-05-29
申请人: Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
发明人: Yunxin Y. Bo , Shon Booker , Marian Bryan , Holly L. Deak , Longbin Liu , Kristin Andrews , Nobuko Nishimura , Mark H. Norman , Kathleen Panter , Laurie Schenkel , Aaron C. Siegmund , Nuria A. Tamayo , Kevin Yang
IPC分类号: A61K31/5377 , C07D413/14 , C07D401/10 , C07D215/233 , A61K31/4709 , A61K31/47 , A61K31/498 , A61P35/00
CPC分类号: C07D401/04 , C07D401/14 , C07D471/04
摘要: The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein Q, X1, X2, R1 and Z are as defined herein.
摘要翻译: 本发明涉及式(I)化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有化合物的药物组合物,其中Q,X 1,X 2,R 1和Z如本文所定义。
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公开(公告)号:US20100273764A1
公开(公告)日:2010-10-28
申请号:US12768602
申请日:2010-04-27
申请人: Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang
发明人: Kristin Andrews , Yunxin Y. Bo , Shon Booker , Victor J. Cee , Noel D'Angelo , Bradley J. Herberich , Fang-Tsao Hong , Claire L.M. Jackson , Brian A. Lanman , Hongyu Liao , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Liping H. Pettus , Anthony B. Reed , Adrian L. Smith , Seifu Tadesse , Nuria A. Tamayo , Bin Wu , Ryan Wurz , Kevin Yang
IPC分类号: A61K31/53 , C07D473/00 , A61K31/52 , C07D401/14 , A61K31/506 , C07D413/14 , A61K31/5377 , C07D401/04 , C07D417/14 , C07D405/14 , A61K31/541 , C07D471/04 , C07D401/12 , C07D513/04 , A61P35/00 , A61P35/02
CPC分类号: C07D473/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14
摘要: The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译: 本发明涉及式I化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物,其中变量如本文所定义。
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公开(公告)号:US20120071474A1
公开(公告)日:2012-03-22
申请号:US13257582
申请日:2010-03-19
申请人: Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
发明人: Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
IPC分类号: A61K31/4355 , C07D487/04 , A61K31/5025 , A61P35/02 , A61K31/5377 , A61K31/519 , C07D471/06 , A61P35/00
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of Formula I, II or III or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译: 本发明涉及式I,II或III化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物,其中变量如本文所定义。
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公开(公告)号:US08729074B2
公开(公告)日:2014-05-20
申请号:US13257582
申请日:2010-03-19
申请人: Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
发明人: Yunxin Y. Bo , Longbin Liu , Nobuko Nishimura , Mark H. Norman , Aaron C. Siegmund , Nuria A. Tamayo , Kevin C. Yang
IPC分类号: A61K31/535
CPC分类号: C07D471/04
摘要: The present invention relates to compounds of Formula I, II or III or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
摘要翻译: 本发明涉及式I,II或III的化合物或其药学上可接受的盐; 使用该化合物治疗疾病或病症如癌症的方法; 和含有这些化合物的药物组合物,其中变量如本文所定义。
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公开(公告)号:US08476297B2
公开(公告)日:2013-07-02
申请号:US12746292
申请日:2008-12-04
申请人: Mark H. Norman , Yunxin Y. Bo , Vijay K. Gore , Daniel Horne , Matthew Kaller , Vu Van Ma , Holger Monenschein , Thomas Nguyen , Nobuko Nishimura , Nuria Tamayo
发明人: Mark H. Norman , Yunxin Y. Bo , Vijay K. Gore , Daniel Horne , Matthew Kaller , Vu Van Ma , Holger Monenschein , Thomas Nguyen , Nobuko Nishimura , Nuria Tamayo
IPC分类号: C07D217/04 , A61K31/47
CPC分类号: C07D217/04 , C07D217/06 , C07D217/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/06
摘要: Tetrahydroisoquinoline compounds of formula (I), and compositions containing them, for the treatment of acute, inflammatory and neurophatic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neurophatic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译: 式(I)的四氢异喹啉化合物和含有它们的组合物,用于治疗急性,炎性和神经性疼痛,牙痛,一般头痛,偏头痛,丛集性头痛,混合血管和非血管综合征,紧张性头痛,一般炎症, 关节炎,风湿性疾病,骨关节炎,炎症性肠病,炎症性眼病,炎性或不稳定性膀胱病,牛皮癣,皮肤炎症成分投诉,慢性炎性病症,炎性疼痛及相关的痛觉过敏和异常性疼痛,神经性疼痛及相关的痛觉过敏和异常性疼痛,糖尿病 神经病痛,咳嗽痛,交感神经保持疼痛,交感综合征,哮喘,上皮组织损伤或功能障碍,单纯疱疹,呼吸道内脏运动紊乱,泌尿生殖道,胃肠道或血管区,伤口,烧伤,过敏性皮肤反应,瘙痒,白癜风,一般 胃肠道 胃溃疡,十二指肠溃疡,腹泻,坏死因子诱导的胃损伤,毛发生长,血管舒缩或过敏性鼻炎,支气管疾病或膀胱疾病。
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公开(公告)号:US20100261728A1
公开(公告)日:2010-10-14
申请号:US12746292
申请日:2008-12-04
申请人: Mark H. Norman , Yunxin Y. Bo , Vijay K. Gore , Daniel Horne , Matthew Kaller , Vu Van Ma , Holger Monenschein , Thomas Nguyen , Nobuko Nishimura , Nuria Tamayo
发明人: Mark H. Norman , Yunxin Y. Bo , Vijay K. Gore , Daniel Horne , Matthew Kaller , Vu Van Ma , Holger Monenschein , Thomas Nguyen , Nobuko Nishimura , Nuria Tamayo
IPC分类号: A61K31/472 , C07D217/18 , C07D401/12 , A61K31/4725 , A61K31/506 , C07D405/06 , C07D413/06 , C07D417/06 , C07D417/12 , C07D405/12 , A61K31/501 , C07D401/04 , A61P29/00 , A61P1/00 , A61P25/06 , A61P25/24 , A61P19/02 , A61P25/22 , A61P11/06 , A61P17/02 , A61P17/00 , A61P13/10 , A61P1/12
CPC分类号: C07D217/04 , C07D217/06 , C07D217/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/06
摘要: Tetrahydroisoquinoline compounds of formula (I), and compositions containing them, for the treatment of acute, inflammatory and neurophatic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neurophatic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译: 式(I)的四氢异喹啉化合物和含有它们的组合物,用于治疗急性,炎性和神经性疼痛,牙痛,一般头痛,偏头痛,丛集性头痛,混合血管和非血管综合征,紧张性头痛,一般炎症, 关节炎,风湿性疾病,骨关节炎,炎症性肠病,炎症性眼病,炎性或不稳定性膀胱病,牛皮癣,皮肤炎症成分投诉,慢性炎性病症,炎性疼痛及相关的痛觉过敏和异常性疼痛,神经性疼痛及相关的痛觉过敏和异常性疼痛,糖尿病 神经病痛,咳嗽痛,交感神经保持疼痛,交感综合征,哮喘,上皮组织损伤或功能障碍,单纯疱疹,呼吸道内脏运动性紊乱,泌尿生殖道,胃肠道或血管区,伤口,烧伤,过敏性皮肤反应,瘙痒,白癜风,一般 胃肠道 胃溃疡,十二指肠溃疡,腹泻,坏死因子诱导的胃损伤,毛发生长,血管舒缩或过敏性鼻炎,支气管疾病或膀胱疾病。
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公开(公告)号:US20090082358A1
公开(公告)日:2009-03-26
申请号:US12284586
申请日:2008-09-22
申请人: Nobuko Nishimura , Mark H. Norman , Nuria Tamayo , Phi Tang , Yunxin Y. Bo
发明人: Nobuko Nishimura , Mark H. Norman , Nuria Tamayo , Phi Tang , Yunxin Y. Bo
IPC分类号: A61K31/4375 , C07D471/04 , A61P29/00 , A61P25/00 , A61K31/4985 , A61K31/519
CPC分类号: C07D471/04
摘要: Bicyclic 3,4-fused piperidine compounds, and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotizing agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译: 双环3,4-稠合哌啶化合物和含有它们的组合物用于治疗急性,炎性和神经性疼痛,牙痛,一般头痛,偏头痛,丛集性头痛,混合血管和非血管性综合征,紧张性头痛,一般炎症 ,关节炎,风湿性疾病,骨关节炎,炎症性肠病,炎症性眼病,炎性或不稳定型膀胱病,牛皮癣,皮肤炎症成分的投诉,慢性炎性病症,炎性疼痛和相关的痛觉过敏和异常性疼痛,神经性疼痛和相关的痛觉过敏和异常性疼痛, 糖尿病性神经病疼痛,咳嗽痛,交感神经保持疼痛,交感综合征,哮喘,上皮组织损伤或功能障碍,单纯疱疹,呼吸道内脏运动紊乱,泌尿生殖道,胃肠道或血管区域,伤口,烧伤,过敏性皮肤反应,瘙痒症,白癜风, 一般胃肠道疾病, 胃溃疡,十二指肠溃疡,腹泻,坏死因子诱导的胃损伤,毛发生长,血管舒缩或过敏性鼻炎,支气管疾病或膀胱疾病。
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公开(公告)号:US07301022B2
公开(公告)日:2007-11-27
申请号:US11354650
申请日:2006-02-15
申请人: Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Hongyu Liao , Mark H. Norman , Markian Stec , Nuria Tamayo , Xianghong Wang
发明人: Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Hongyu Liao , Mark H. Norman , Markian Stec , Nuria Tamayo , Xianghong Wang
IPC分类号: C07D239/34 , C07D239/38 , C07D237/14 , C07D237/18 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , A61K31/505 , A61K31/506 , A61K31/4427 , A61P19/02 , A61P35/00
CPC分类号: C07D403/14 , C07D401/14 , C07D417/12 , C07D417/14
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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公开(公告)号:US20090264424A1
公开(公告)日:2009-10-22
申请号:US12492376
申请日:2009-06-26
申请人: Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
发明人: Yunxin Y. Bo , Partha P. Chakrabarti , Ning Chen , Elizabeth M. Doherty , Christopher H. Fotsch , Nianhe Han , Michael G. Kelly , Qingyian Liu , Mark Henry Norman , Vassil I. Ognyanov , Xianghong Wang , Jiawang Zhu
IPC分类号: A61K31/536 , C07D265/36 , A61P29/00
CPC分类号: C07D471/04 , C07D209/08 , C07D209/12 , C07D209/42 , C07D209/48 , C07D213/26 , C07D213/643 , C07D213/74 , C07D213/75 , C07D215/227 , C07D215/38 , C07D217/04 , C07D231/40 , C07D231/56 , C07D233/38 , C07D237/20 , C07D239/42 , C07D239/90 , C07D241/42 , C07D263/56 , C07D265/36 , C07D277/62 , C07D277/82 , C07D307/79 , C07D319/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
摘要翻译: 具有一般结构和含有它们的组合物的化合物,用于治疗急性,炎性和神经性疼痛,牙痛,一般头痛,偏头痛,丛集性头痛,混合血管和非血管综合征,紧张性头痛,一般炎症,关节炎,风湿性 疾病,骨关节炎,炎症性肠病,炎症性眼病,炎症性或不稳定性膀胱病,银屑病,皮肤炎症成分炎症,慢性炎性病症,炎性疼痛及相关的痛觉过敏和异常性疼痛,神经性疼痛及相关的痛觉过敏和异常性疼痛,糖尿病性神经病疼痛, 咳嗽痛,交感神经痛,交感综合征,哮喘,上皮组织损伤或功能障碍,单纯疱疹,呼吸道内脏运动紊乱,泌尿生殖道,胃肠道或血管区,伤口,烧伤,过敏性皮肤反应,瘙痒症,白癜风,一般胃肠道疾病, G 腹部溃疡,十二指肠溃疡,腹泻,坏死因子诱发的胃损伤,毛发生长,血管舒缩或过敏性鼻炎,支气管疾病或膀胱疾病。
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