公开(公告)号：US4740498A

公开(公告)日：1988-04-26

申请号：US790668

申请日：1985-10-23

申请人： Yutaka Hirao ,  Takao Ohmura ,  Kazuo Takechi ,  Tsunetaka Nakajima ,  Masayuki Nishida

发明人： Yutaka Hirao ,  Takao Ohmura ,  Kazuo Takechi ,  Tsunetaka Nakajima ,  Masayuki Nishida

IPC分类号： A61K38/16 ,  A61K9/00 ,  A61K38/39 ,  A61K47/10 ,  A61K47/26 ,  A61K47/42 ,  A61K37/04 ,  A61K35/14 ,  A61K37/02

CPC分类号： A61K47/42 ,  A61K38/39 ,  A61K47/10 ,  A61K47/26 ,  A61K9/0048

摘要： A fibronectin preparation in the form of an aqueous solution at least upon use is disclosed. The preparation contains at least one member selected from the group consisting of disaccharides, albumin and nonionic surface active agents as a stabilizer. The preparation has improved water-solubility when in use and high stability in an aqueous solution.

摘要翻译： 公开了至少使用水溶液形式的纤连蛋白制剂。 该制剂含有选自二糖，白蛋白和非离子表面活性剂作为稳定剂的至少一种。 该制剂在使用时具有改善的水溶性和在水溶液中的高稳定性。

公开(公告)号：US4849425A

公开(公告)日：1989-07-18

申请号：US824088

申请日：1986-01-30

申请人： Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Tadakazu Suyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

发明人： Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Tadakazu Suyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

IPC分类号： C07C273/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61K31/44 ,  A61K31/505 ,  A61K47/10 ,  A61K47/40 ,  A61K47/44 ,  C07D239/34

CPC分类号： A61K9/02 ,  A61K31/44 ,  A61K31/505 ,  A61K47/10 ,  A61K47/40 ,  A61K47/44 ,  A61K9/0019 ,  A61K9/2013 ,  A61K9/4858 ,  C07D239/34 ,  Y10S514/946

摘要： A pharmaceutical composition comprises a benzoyl urea compound having the formula: ##STR1## wherein X is a nitro group, Y is a chlorine atom, Z.sub.2 is a hydrogen atom, Z.sub.1 is a halogen atom, and A is a nitrogen atom, and at least one member selected from the group consisting of a cyclodextrin, a polyethylene glycol and a refined oil.

公开(公告)号：US5098907A

公开(公告)日：1992-03-24

申请号：US469054

申请日：1990-01-23

申请人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kouichi Yamauchi ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

发明人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kouichi Yamauchi ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

IPC分类号： A61K9/14 ,  A61K31/44 ,  A61K31/505 ,  A61K47/14 ,  A61K47/26 ,  A61P35/00

CPC分类号： A61K9/14 ,  A61K31/44 ,  A61K31/505 ,  A61K47/14 ,  A61K47/26 ,  Y10S514/975

摘要： A powdery pharmaceutical composition comprising a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is CH or a nitrogen atom, as an active ingredient, a nonionic surfactant as a dispersant, at least one member selected from the group consisting of sugar, sugar-alcohol and a nonionic surfactant as a disintegrant, and anhydrous silicic acid as a fluidizer.

公开(公告)号：US5036072A

公开(公告)日：1991-07-30

申请号：US469052

申请日：1990-01-23

申请人： Tsunetaka Nakajima ,  Tadao Okamoto ,  Masahiro Watanabe ,  Kazumasa Yokoyama

发明人： Tsunetaka Nakajima ,  Tadao Okamoto ,  Masahiro Watanabe ,  Kazumasa Yokoyama

IPC分类号： C07D239/34 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/505 ,  A61P31/12 ,  C07D213/64

CPC分类号： A61K31/44 ,  A61K31/505

摘要： Use of a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is CH or a nitrogen atom, as an antiviral agent.

公开(公告)号：US4727077A

公开(公告)日：1988-02-23

申请号：US823521

申请日：1986-01-29

申请人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama

发明人： Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi ,  Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama

IPC分类号： C07C273/00 ,  A61K9/00 ,  A61K9/02 ,  A61K9/20 ,  A61K9/48 ,  A61K31/44 ,  A61K31/505 ,  A61K47/10 ,  A61K47/40 ,  A61K47/44 ,  C07D239/34 ,  C07D251/22 ,  A61K31/53

CPC分类号： A61K9/02 ,  A61K31/44 ,  A61K31/505 ,  A61K47/10 ,  A61K47/40 ,  A61K47/44 ,  A61K9/0019 ,  A61K9/2013 ,  A61K9/4858 ,  C07D239/34 ,  Y10S514/946

摘要： A benzoyl urea compound having the formula: ##STR1## wherein A is a bromine atom or a chlorine atom.

摘要翻译： 具有下式的苯甲酰脲化合物：其中A是溴原子或氯原子。

公开(公告)号：US5116949A

公开(公告)日：1992-05-26

申请号：US400941

申请日：1989-08-31

申请人： Tsunetaka Nakajima ,  Tadao Okamoto ,  Nobuo Kondo ,  Masahiro Watanabe ,  Koichi Yamauchi ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

发明人： Tsunetaka Nakajima ,  Tadao Okamoto ,  Nobuo Kondo ,  Masahiro Watanabe ,  Koichi Yamauchi ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

IPC分类号： A61K31/44 ,  A61K31/4418 ,  A61K31/505 ,  A61K38/16 ,  A61K47/48 ,  A61P35/00 ,  C07D213/64 ,  C07D213/647 ,  C07D239/34 ,  C07K14/00 ,  C07K14/435 ,  C07K14/76

CPC分类号： C07D213/647 ,  A61K31/44 ,  A61K31/505 ,  A61K47/48284 ,  C07D239/34

摘要： A benzoyl urea compound-albumin complex comprising a benzoyl urea compound of the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom and A is CH or a nitrogen atom, and albumin.

公开(公告)号：US5002952A

公开(公告)日：1991-03-26

申请号：US385998

申请日：1989-07-27

申请人： Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

发明人： Nobuo Kondo ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

IPC分类号： A61K47/44 ,  A61K9/14 ,  A61K31/44 ,  A61K31/505 ,  A61K47/06 ,  A61P35/00 ,  C07D213/64

CPC分类号： A61K9/145 ,  A61K31/44 ,  A61K31/505 ,  Y10S514/941 ,  Y10S514/975

摘要： A pharmaceutical composition comprising a benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH--group or a nitrogen atom, and a nonionic surfactant.

摘要翻译： 一种药物组合物，其包含具有下式的苯甲酰脲化合物：其中X为卤素原子或硝基，Y为氢原子，卤素原子，硝基或三氟甲基，Z1为 卤素原子或三氟甲基，Z 2为氢原子或卤素原子，A为= CH-基或氮原子，和非离子表面活性剂。

公开(公告)号：US4983605A

公开(公告)日：1991-01-08

申请号：US110284

申请日：1987-10-20

申请人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

发明人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

IPC分类号： A61K9/14 ,  A61K9/19 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505 ,  A61K47/14 ,  A61K47/26

CPC分类号： A61K31/505 ,  A61K31/44 ,  A61K31/50 ,  A61K9/145 ,  A61K9/146 ,  A61K9/19 ,  A61K47/14 ,  A61K47/26 ,  Y10S514/961 ,  Y10S514/964

摘要： A pharmaceutical composition comprising a benzoyl urea compound (A) selected from the group consisting of a benzoyl urea compound (I) having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, and a benzoyl urea compound (II) having the formula: ##STR2## wherein each of X.sub.1 and X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, as an active ingredient; a nonionic surfactant as a dispersant; and at least one member selected from the group consisting of a saccharide, a saccharide alcohol, silicic anhydride and a nonionic surfactant, as a disintegrator.

摘要翻译： 提供一种药物组合物，其包含选自具有下式的苯甲酰脲化合物（I）的苯甲酰脲化合物（A）：其中X为卤素原子，硝基或三氟甲基，其提供 当Y为硝基时，X为卤原子或硝基，Y为氢原子，卤原子，硝基或三氟甲基，Z1为卤原子或三氟甲基，Z2为氢 原子或卤素原子，A为= CH-基或氮原子，和具有下式的苯甲酰脲化合物（II）：其中X1和X2各自为氢原子，卤素 原子或硝基，条件是当Y为硝基时，X 1为氢原子，Y为氢原子，卤素原子，硝基或三氟甲基，Z为氢原子，卤素原子或 三氟甲基作为活性成分; 作为分散剂的非离子表面活性剂; 和选自糖，糖醇，硅酸酐和非离子表面活性剂的至少一种作为崩解剂。

公开(公告)号：US4904668A

公开(公告)日：1990-02-27

申请号：US101005

申请日：1987-09-25

申请人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

发明人： Nobuo Kondo ,  Masahiro Kikuchi ,  Tsunetaka Nakajima ,  Masahiro Watanabe ,  Kazumasa Yokoyama ,  Takahiro Haga ,  Nobutoshi Yamada ,  Hideo Sugi ,  Toru Koyanagi

IPC分类号： A61K9/14 ,  C07D213/64 ,  C07D213/643 ,  C07D237/14 ,  C07D239/34

CPC分类号： C07D213/643 ,  A61K9/14 ,  A61K9/145 ,  A61K9/146 ,  C07D237/14 ,  C07D239/34

摘要： A benzoyl urea compound having the formula: ##STR1## wherein X is a halogen atom, a nitro group or a trifluoromethyl group, provided that when Y is a nitro group, X is a halogen atom or a nitro group, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, Z.sub.1 is a halogen atom or a trifluoromethyl group, Z.sub.2 is a hydrogen atom or a halogen atom, and A is a .dbd.CH-- group or a nitrogen atom, or the formula: ##STR2## wherein each of X.sub.1 is X.sub.2 is a hydrogen atom, a halogen atom or a nitro group, provided that when Y is a nitro group, X.sub.1 is a hydrogen atom, Y is a hydrogen atom, a halogen atom, a nitro group or a trifluoromethyl group, and Z is a hydrogen atom, a halogen atom or a trifluoromethyl group, characterized in that its average particle size is not larger than 1 .mu.m.

摘要翻译： 具有下式的苯甲酰脲化合物：其中X是卤素原子，硝基或三氟甲基，条件是当Y是硝基时，X是卤原子或硝基，Y是 氢原子，卤素原子，硝基或三氟甲基，Z1为卤素原子或三氟甲基，Z2为氢原子或卤素原子，A为a-CH-基或氮原子，或 其中X 1为X 2的每一个为氢原子，卤原子或硝基的式：其中Y为硝基时，X 1为氢原子，Y为氢原子， 卤原子，硝基或三氟甲基，Z为氢原子，卤素原子或三氟甲基，其特征在于，其平均粒径为1μm以下。