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    Pyrimidine derivative condensed with a non-aromatic ring
    7.
    发明授权
    Pyrimidine derivative condensed with a non-aromatic ring 失效
    与非芳香环稠合的嘧啶衍生物

    公开(公告)号：US07947690B2

    公开(公告)日：2011-05-24

    申请号：US11577648

    申请日：2005-10-17

    申请人： Yasuhiro Yonetoku ,  Kenji Negoro ,  Kenichi Onda ,  Masahiko Hayakawa ,  Daisuke Sasuga ,  Takahiro Nigawara ,  Kazuhiko Iikubo ,  Hiroyuki Moritomo ,  Shigeru Yoshida ,  Takahide Ohishi

    发明人： Yasuhiro Yonetoku ,  Kenji Negoro ,  Kenichi Onda ,  Masahiko Hayakawa ,  Daisuke Sasuga ,  Takahiro Nigawara ,  Kazuhiko Iikubo ,  Hiroyuki Moritomo ,  Shigeru Yoshida ,  Takahide Ohishi

    IPC分类号： A61K31/519 ,  A61K31/497 ,  C07D495/04 ,  A61P3/10 ,  C07D487/04 ,  C07D471/04 ,  C07D239/72 ,  A61K31/517

    CPC分类号： C07D239/70 ,  C07D239/94 ,  C07D495/04

    摘要： The present invention provides a condensed pyrimidine compound represented by formula (I) or pharmaceutically acceptable salt thereof: where A represents a ring where at least one carbon atom within said ring is optionally substituted with one or more groups selected from the group consisting of lower alkyl, —O-(lower alkyl), halogen atom, carboxyl, —CO2-(lower alkyl), and carbamoyl, R1 represents: (1) phenyl substituted with at least three halogen atoms, which may have at least one additional substituent, or (2) cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, or cycloheptyl, each of which is optionally substituted; and R2 represents a group represented by formula (II) or an optionally substituted cyclic amino: wherein R21 and R22 may be identical or different and each represents —H, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, phenyl, heteroaryl, non-aromatic heterocyclyl, or —O-(lower alkyl), each of which is optionally substituted.

    摘要翻译： 本发明提供由式（I）表示的稠合嘧啶化合物或其药学上可接受的盐：其中A表示环，其中所述环中至少一个碳原子任选被一个或多个选自以下的基团取代：低级烷基 ，-O-（低级烷基），卤素原子，羧基，-CO 2 - （低级烷基）和氨基甲酰基，R 1表示：（1）被至少三个卤素原子取代的苯基，其可以具有至少一个另外的取代基，或 （2）环丙基，环丁基，环戊基，环己基或环庚基，其各自任选被取代; 并且R 2表示由式（II）表示的基团或任选取代的环状氨基：其中R 21和R 22可以相同或不同，并且各自表示-H，低级烷基，低级烯基，低级炔基，环烷基，苯基，杂芳基， 芳族杂环基或-O-（低级烷基），其各自任选被取代。